LOCUS       NM_144914               1859 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus transmembrane protein 184a (Tmem184a), transcript
            variant 2, mRNA.
ACCESSION   NM_144914
VERSION     NM_144914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Tang,F., Richardson,N., Albina,A., Chaboissier,M.C. and
            Perea-Gomez,A.
  TITLE     Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4
            and the Pro-Testis Factor SOX9
  JOURNAL   Cells 9 (5), 1103 (2020)
   PUBMED   32365547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Chassot,A.A., Bradford,S.T., Auguste,A., Gregoire,E.P.,
            Pailhoux,E., de Rooij,D.G., Schedl,A. and Chaboissier,M.C.
  TITLE     WNT4 and RSPO1 together are required for cell proliferation in the
            early mouse gonad
  JOURNAL   Development 139 (23), 4461-4472 (2012)
   PUBMED   23095882
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Lavery,R., Chassot,A.A., Pauper,E., Gregoire,E.P., Klopfenstein,M.,
            de Rooij,D.G., Mark,M., Schedl,A., Ghyselinck,N.B. and
            Chaboissier,M.C.
  TITLE     Testicular differentiation occurs in absence of R-spondin1 and Sox9
            in mouse sex reversals
  JOURNAL   PLoS Genet 8 (12), e1003170 (2012)
   PUBMED   23300469
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Ogaki,S., Harada,S., Shiraki,N., Kume,K. and Kume,S.
  TITLE     An expression profile analysis of ES cell-derived definitive
            endodermal cells and Pdx1-expressing cells
  JOURNAL   BMC Dev Biol 11, 13 (2011)
   PUBMED   21362171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Auguste,A., Chassot,A.A., Gregoire,E.P., Renault,L., Pannetier,M.,
            Treier,M., Pailhoux,E. and Chaboissier,M.C.
  TITLE     Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal
            in XX mice
  JOURNAL   Sex Dev 5 (6), 304-317 (2011)
   PUBMED   22116255
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Best,D. and Adams,I.R.
  TITLE     Sdmg1 is a component of secretory granules in mouse secretory
            exocrine tissues
  JOURNAL   Dev Dyn 238 (1), 223-231 (2009)
   PUBMED   19097053
  REMARK    GeneRIF: These data suggest that Sdmg1 is a component of regulated
            secretory granules in exocrine secretory cells and that the
            developmental regulation of Sdmg1 expression is related to a role
            for Sdmg1 in post-Golgi membrane trafficking.
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Best,D., Sahlender,D.A., Walther,N., Peden,A.A. and Adams,I.R.
  TITLE     Sdmg1 is a conserved transmembrane protein associated with germ
            cell sex determination and germline-soma interactions in mice
  JOURNAL   Development 135 (8), 1415-1425 (2008)
   PUBMED   18321981
  REMARK    GeneRIF: identified a conserved transmembrane protein, Sdmg1, owing
            to its male-specific expression in embryonic gonads
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Svingen,T., Beverdam,A., Bernard,P., McClive,P., Harley,V.R.,
            Sinclair,A.H. and Koopman,P.
  TITLE     Sex-specific expression of a novel gene Tmem184a during mouse
            testis differentiation
  JOURNAL   Reproduction 133 (5), 983-989 (2007)
   PUBMED   17616727
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY230075.1 and AK148454.1.
            
            On Jun 4, 2009 this sequence version replaced NM_144914.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream
            translational start codon, compared to variant 1. The resulting
            isoform (2) is shorter at the N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148454.1, SRR5189685.172233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY230075.1         1-29
            30-1859             AK148454.1         2-1831
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.81 cM"
     gene            1..1859
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /note="transmembrane protein 184a"
                     /db_xref="GeneID:231832"
                     /db_xref="MGI:MGI:2385897"
     exon            1..279
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1329
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sexually dimorphic expressed in male gonads 1"
                     /codon_start=1
                     /product="transmembrane protein 184A isoform 2"
                     /protein_id="NP_659163.3"
                     /db_xref="CCDS:CCDS39354.1"
                     /db_xref="GeneID:231832"
                     /db_xref="MGI:MGI:2385897"
                     /translation="MRNASGFLKTAGAPLVSATWLPPSPPPAMPTVAAGPQMERVDNG
                     SQGAPQLFLTSALARGVSGVFVWTALLLTGHQIYSHLRSYTAPREQRFVIRLLFIVPI
                     YAFDSWLSLLLLGGHPYYVYFDSVRDCYEAFVIYSFLTLCFQYLGGESAIMAEIRGKP
                     IRSSCFYGTCCLRGMSYSITFLRFCKQATLQFCIVKPVMALITIILQAFDKYHDGDFN
                     IHSGYLYVTLVYNASVSLALYALFLFYFATRDLLRPFEPVLKFLTIKAIIFLSFWQGM
                     LLAILERCGVIPEVQAVDGTRVGAGTLAAGYQNFLICVEMLFASLALRYAFPSQVYSE
                     KKNSPVPPAPMQSISSGLKETISPQDIVQDAIHNFSPAYQQYTQQSTHEAPGPGQGGH
                     PAPSTHPGPASGSGGGKKSRNIEKRMLIPSEDL"
     exon            280..445
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..536
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..612
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..704
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..874
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1069
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1859
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /note="hexamer: GATAAA"
     polyA_site      1859
                     /gene="Tmem184a"
                     /gene_synonym="Sdmg1"
                     /note="major polyA site"
ORIGIN      
        1 actcccacag aagccttccc tggcttctca ctcctctgct ggtttctgca gatgaggaat
       61 gcgtcagggt ttctgaagac agccggagcc cccctcgtgt cagcgacctg gcttccaccc
      121 agcccccctc cggcaatgcc cacagtggca gccgggccac agatggagcg cgtggacaac
      181 ggctcgcagg gggcccccca gctcttcctc accagcgcat tggcccgagg cgtttcaggc
      241 gtgtttgtat ggactgctct gctgctaacc ggccaccaga tctactccca cctacgttcc
      301 tataccgccc cgcgagagca gcgcttcgtc atccgcctcc tgttcattgt gcccatctac
      361 gccttcgact cctggctcag cctcctcctc cttgggggcc atccttacta cgtctacttc
      421 gactctgtgc gagactgcta cgaagcattt gtcatctaca gtttcctgac cttgtgcttc
      481 caatatctgg ggggcgagag cgccatcatg gctgagatcc gaggcaaacc tatcaggtcc
      541 agctgcttct atgggacctg ctgcctccgt ggtatgtcct actccatcac gttcttacgc
      601 ttctgcaaac aggccacact ccagttctgc attgtgaaac ccgttatggc gctgatcacc
      661 atcatcctcc aggcttttga caaataccac gatggggact tcaacatcca cagcggctac
      721 ctgtacgtga ccctcgtgta caatgcctcg gtcagcctgg ctctctacgc tctgttcctt
      781 ttctacttcg ctaccaggga cctcctgaga cccttcgagc cggtactcaa gttcctcacc
      841 atcaaagcca tcatcttcct ctccttctgg cagggaatgc tgttggccat cttggagagg
      901 tgtggggtca tccctgaggt ccaggccgtg gacggcacca gggttggggc tggtacccta
      961 gccgctggct accagaattt cctcatctgt gttgagatgc tgttcgcctc cctcgcgctg
     1021 cgttacgcct tccccagcca ggtgtattca gagaagaaga actcaccagt cccgccagca
     1081 cctatgcaaa gcatatccag tggcttaaag gagaccatca gcccacagga cattgtccag
     1141 gacgccattc ataacttctc gccagcctac cagcagtaca cacagcagtc cacacatgaa
     1201 gctcctgggc ctggccaggg tgggcaccca gcacccagta cccaccccgg cccagccagt
     1261 ggctctggag gtggtaagaa gagtcgcaac atagagaaac gcatgctgat tccctcagag
     1321 gacctgtagg ggcgcagggc gcgtggaacc tagctgggga tccagcttgc ctgggtttct
     1381 ggggtggtaa acagggaccc ccacctacca gcatctcttg acagaggccc aacctctccc
     1441 gagagcctca cagggcctct gtattccatg tacagcccag agtgaagtca cctgggcaaa
     1501 ttggaccaac cagaggaccc agtggaatgt cttaattata gcctgcaggt gaagctgtgg
     1561 gttggccatt ccttccatgg acagaagaga caggtggtta gatcttacgc tgagcagcga
     1621 cagagaggga tggccaggca ggatgggccc agtcactgag tgctggggag ccacatagcc
     1681 tgggcctggc tgtggctatc ttgggtgaag aagatccctt gcccttgcat tctaacctag
     1741 aaagttggcg aggctctcgc aggggcagcc tagcctattt agcacaacag agttgccagt
     1801 gcgccagcct accagcaact atctgcttat ttatagataa acaccttgca ttttctaga
//
