LOCUS       NM_001357884            4524 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 181A (Tmem181a), transcript
            variant 2, mRNA.
ACCESSION   NM_001357884 XM_006523257
VERSION     NM_001357884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4524)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4524)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4524)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 4524)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   5  (bases 1 to 4524)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
REFERENCE   6  (bases 1 to 4524)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092481.28, AC183097.2 and CF747635.1.
            
            On Nov 10, 2017 this sequence version replaced XM_006523257.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC092481.28        3047-3261           c
            216-319             AC183097.2         85576-85679
            320-375             AC183097.2         91904-91959
            376-463             AC183097.2         93964-94051
            464-585             AC183097.2         95535-95656
            586-696             AC183097.2         99902-100012
            697-777             AC183097.2         100700-100780
            778-877             AC183097.2         102206-102305
            878-1008            AC183097.2         102830-102960
            1009-1100           AC183097.2         103127-103218
            1101-1158           AC183097.2         104341-104398
            1159-1261           AC183097.2         105870-105972
            1262-1313           AC183097.2         106380-106431
            1314-1396           AC183097.2         108199-108281
            1397-1486           AC183097.2         109224-109313
            1487-1553           AC183097.2         109555-109621
            1554-4147           AC183097.2         110347-112940
            4148-4524           CF747635.1         115-491
FEATURES             Location/Qualifiers
     source          1..4524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 3.85 cM"
     gene            1..4524
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /note="transmembrane protein 181A"
                     /db_xref="GeneID:77106"
                     /db_xref="MGI:MGI:1924356"
     exon            1..215
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1632
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transmembrane protein 181"
                     /codon_start=1
                     /product="transmembrane protein 181 isoform 2"
                     /protein_id="NP_001344813.1"
                     /db_xref="CCDS:CCDS88983.1"
                     /db_xref="GeneID:77106"
                     /db_xref="MGI:MGI:1924356"
                     /translation="MDAEYPAFEPPLCSGLKQLCRRLQEAYRELKEDLAPFKDDRYYR
                     LAPMRLYTLSKRHFVLVFVVFFICFGLTVFVGIEGPRVIETLPANYSLNSSKKLKTVI
                     PSNPLSTYNQQLWLMCVVELEPSEETSIQTSFTMTVKVDGVSQDGTTTYIHNKVHNRT
                     RTLTCAGKCAEIIVAHLGYLNYTQYRVTVGFEHLNQPIKDMNFTWKTYNPAFSRLEIW
                     FHFVFVVLTFIVICLFVHSLRKFSMRDWGIEQKWMSVLLALLLLYNDPFFPLSFLVNS
                     WFPGMLDDFFQSLFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTL
                     GIWQTFNELNDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYV
                     DLRLKFLTALTFVVLVISIVILYLRFGAQVLQDNFVAELSAHYQNSAEFLSFYGLLNF
                     YLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKC
                     REESDSD"
     exon            216..319
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            320..375
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            376..463
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            464..585
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            586..696
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            697..777
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            778..877
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1008
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1100
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1158
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1261
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1313
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1396
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1486
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1553
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..4499
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4366..4371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /note="hexamer: AATAAA"
     polyA_site      4391
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
     regulatory      4474..4479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /note="hexamer: AATAAA"
     polyA_site      4499
                     /gene="Tmem181a"
                     /gene_synonym="5930418K15Rik; Gpr178; mKIAA1423; Tmem181"
                     /note="major polyA site"
ORIGIN      
        1 gccataggct cgggtgcggg gagctggcgg cggagagggg gcgaggacgg cgattgcgag
       61 ggcggagcgc agcgcggcgc gggcatggac gcggagtacc ctgcgttcga gccgccgctc
      121 tgcagtggcc tcaagcagct gtgccggcgg ctgcaggagg cgtaccgcga gctcaaggag
      181 gacctcgcgc cattcaagga tgatcgctac tacaggttgg cacccatgcg gctctatacg
      241 ctctccaagc gccacttcgt ccttgtgttt gttgtcttct tcatctgttt tggactgacc
      301 gtcttcgtcg gcatcgaggg acccagagtg atcgagactt tgcctgctaa ttattcactc
      361 aatagtagca aaaagctaaa gacagttata ccttcaaacc cactgtccac atataaccaa
      421 caactatggc tgatgtgcgt tgtggagctg gagccctcag aagaaacatc catccaaacc
      481 agcttcacca tgacagtgaa ggtcgatggt gtgtctcaag atggaaccac gacgtacatc
      541 cataacaagg ttcacaaccg gacgaggacc ctcacgtgtg cagggaaatg tgcagaaatc
      601 atcgtggccc accttggcta cctgaattac acacagtaca gggttactgt ggggtttgag
      661 cacctgaacc agcccatcaa ggatatgaac ttcacgtgga agacatacaa ccctgcgttt
      721 tcccggctgg agatctggtt ccacttcgtg tttgtggtgc tcaccttcat cgtgatttgc
      781 ctgtttgtac attccctgcg caagttctcc atgagggact ggggcatcga gcagaagtgg
      841 atgtctgtcc tcctggccct gctgctgctc tacaatgacc ctttcttccc actctccttc
      901 ttggtgaata gctggttccc ggggatgctg gacgacttct tccagtctct gttcctgtgt
      961 gccctgctgc tcttctggct gtgcgtgtat catgggatac gggtccaggg agagagaaaa
     1021 tgtttaactt tctatttgcc taagttcttc atcgttggac tgctgtggct ggcttctgtc
     1081 actctgggaa tatggcagac atttaatgaa ttaaatgatc ccatgtacca gtatcgggtt
     1141 gacaccggaa actttcaggg catgaaggtc ttcttcatgg tggtggccgc tgtgtacatt
     1201 ttataccttc tattcttgat agtgcgagca tgctccgagc tccgtcatat gccttacgtg
     1261 gatctcaggt taaagttttt gactgcgttg acctttgtag tgctagttat tagcatcgtc
     1321 atcctctacc tacggtttgg agcacaagtg ttgcaggaca acttcgtagc agaactgtcg
     1381 gctcactacc agaactcagc tgaattcctg tctttctatg gcctgttgaa cttttacttg
     1441 tacacgctgg cctttgtgta ctctccgtcg aagaatgccc tgtacgagtc ccagctgaag
     1501 gataaccctg cgttttccat gttgaacgac tctgacgatg acgtgattta cgggagtgac
     1561 tatgaagaaa tgcccctgca gaacggccag gccatccgtg ccaagtgcag ggaagagtcg
     1621 gacagtgact gagccccggg cagcagatgg gacagcaggg ggccagaggc ctgcctgagt
     1681 gacacattct ggccccttct atctgtttgt gtctggactc ctctgtaagc aaaggtttcc
     1741 tgttccttat ttgtttacat atttttaaaa gaaaacccaa atggattgaa atgtggggcg
     1801 gagtttgctt tgggggcagc cccactcttt aagaagaggg gctgcctggt agagaattca
     1861 aaggcatatc ctgtacaccg acatcaggtg cgatggagcc cgtatgcagt catgaggaga
     1921 agttacccat ttttaataaa aagaattatg tactttttct ttccttttaa aaaagcaatt
     1981 gagtctgtgg gaggcctgac gatcaaggtc ccagcgtggc agtgatgact ctctcctctc
     2041 tgtggcaccg ttcttgagtg ccctaccctc aagggaagtc taagctgtgc ccgcctcagg
     2101 tgggcggtct gcctccctct tctccagcac atgatggggt cagtatgctc actcaggcat
     2161 ctgctgtgag actttgattg ggtttgatga gccacattca atagcatctt caggaatggc
     2221 aagtggccag gttcccgtcc atcattgcca ccccccaccc ccagcagaat tgccatccaa
     2281 gttgagtcca gagtgggctg atagcctgga ggaagcccag gcagctacag gccagtagcg
     2341 ctgtgggcaa ggtcctgtgt catggtgctt ttcaagggtc tgtgtacagt taggattggg
     2401 tctccctgtg ctggaggtgg aaaacgagga ggcccttccg accaaaattt cttcatcttc
     2461 actgagtgtg aaccccccgg agagctctat tattattttt tttaaatcaa agctacataa
     2521 aatacaactg tattagaaat actttattgc cagaaagact ttctgtttta attaggaact
     2581 aaagtaaaga gaaagtaaga cattttgaat ggctatagag acagctgcag atgaagggag
     2641 tccccccaag gttgttctgg gtttggagtg tggctctgtg gaaaacggat gtcacccaca
     2701 ctgaagttca gcattggaag tcctcagggc caccgccttc cttcccgctc ctcagtttcc
     2761 ccacacagcg tctctgcgaa cacctggtaa aggtagcatc ctgcctgcct ctgtcttggc
     2821 aaatccagag gcccagttcc ggtagatccc tcttctgttc ccttcgtctg tgcaccgact
     2881 cagatttccg ctctgagctg caggttactg tccgtgtggg cccgactcca gggtggaaga
     2941 cgttcttcag tctgcctgtc ttcttaaact tcatacttta atatggattc catgtgcatt
     3001 ttttttaaaa acaaaacaac ttgtaactat gaacattgga atggaaactc actgcgaggg
     3061 taacgggttt acatgagttt gcacttgctg tgatcactga gtctgttggg gaagatacca
     3121 gaatatctta tgttaccagc ccttcccttc cagtggagcc ctgcagctgc catcttatgg
     3181 acgctgactc gtactgatcc caagatgttc gaatatgtga gagtttacat gtcttcatca
     3241 ttataaataa gtctccatgg tttataacac tatgtatcag tcagtgtaag atattttaag
     3301 catttaggta cagacttcag aacttttaaa aactgcccta tagaataatt ataaactgat
     3361 cctagtgtcc gtaaaactaa gggaatattt tttttgctgt tgaaatatga attataaagc
     3421 agcactccta gggtcgtgtg catcctgtat tagatgctgt gcaaagctct gcttacagaa
     3481 ctaagacttc agtgtgtagg cagcagctca ggggtgagct taaaacacta aactccgcca
     3541 ggacttttga tagtcaccag aagactgttc tgttctgagg ggattaaaat tttgtaaact
     3601 taaattataa gttcaaaggg ctgacttagt tctttcaggg taacggtttg aatcctcctg
     3661 tctttggggt attttttata ttggtccaat ccaggggaac ctggaaggtg acggctccca
     3721 gattcccggt gagagcttca ttttccctgt gggtagtaaa tctgcgtgat ttattgtcat
     3781 tcatggcagc agtgattcgg tgccttcaag ccccatcgaa aggctagaga agagggtatg
     3841 taaacttaca tccgaggctc gtgaggcgct tgctctctgt acagttagac tgaagtaagc
     3901 ttaggtatgt aaagccatcc tgcagatggg cagtttataa agcaaatctc gccagcctca
     3961 agtgctgaac cattgaaggc acagttagga tgaacaggtt caaatatggt tactaatctt
     4021 tataggaaaa acacaagcac ccacaaaaga gagaactaag tccctccatg aggaacagat
     4081 atgaggcttg atatgtattg tatatttgag cgtttgcctt agtgattaca tttttggggg
     4141 ttgggggaga tgtggctctt tttttttttt ttttttttca ggccaaagga aaatggatgt
     4201 cgtcagaagc cttgctgaat gtttctcttg gtggctcggg tgctgctagg tgctaccatt
     4261 ctgtgatctg tcctgtgaca cagaacaggt taattccatt gtatgacaga gggattttct
     4321 gctcctgaaa actacctttt tacaaatgtc tgtaaatatc tgttaaataa aaacactaac
     4381 ctctaagtcc agaaggaaca ccgtttgacc atcagtgcac cactgttgtc tgagcagtca
     4441 gtcaaggaat aaatgcttat ttatgaaaaa ctcaataaaa gtcacatttt gagattttga
     4501 aaaaaaaaaa aaaaaaaaaa aaaa
//
