LOCUS       NP_742046                140 aa            linear   ROD 30-APR-2024
DEFINITION  transmembrane protein 18 [Mus musculus].
ACCESSION   NP_742046 XP_915095 XP_926595
VERSION     NP_742046.2
DBSOURCE    REFSEQ: accession NM_172049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 140)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 140)
  AUTHORS   Larder,R., Sim,M.F.M., Gulati,P., Antrobus,R., Tung,Y.C.L.,
            Rimmington,D., Ayuso,E., Polex-Wolf,J., Lam,B.Y.H., Dias,C.,
            Logan,D.W., Virtue,S., Bosch,F., Yeo,G.S.H., Saudek,V.,
            O'Rahilly,S. and Coll,A.P.
  TITLE     Obesity-associated gene TMEM18 has a role in the central control of
            appetite and body weight regulation
  JOURNAL   Proc Natl Acad Sci U S A 114 (35), 9421-9426 (2017)
   PUBMED   28811369
REFERENCE   4  (residues 1 to 140)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY013255.1, AK160817.1 and AI835036.1.
            
            On Oct 6, 2007 this sequence version replaced NP_742046.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024093.1, AK133493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..140
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     Protein         1..140
                     /product="transmembrane protein 18"
                     /calculated_mol_wt=16395
     Region          16..127
                     /region_name="TMEM18"
                     /note="Transmembrane protein 18; pfam14770"
                     /db_xref="CDD:405460"
     Site            26..46
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TUD9.1)"
     Site            53..73
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TUD9.1)"
     Site            92..112
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TUD9.1)"
     Region          113..140
                     /region_name="DNA-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TUD9.1)"
     Region          130..138
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TUD9.1)"
     CDS             1..140
                     /gene="Tmem18"
                     /coded_by="NM_172049.2:64..486"
                     /db_xref="CCDS:CCDS49043.1"
                     /db_xref="GeneID:211986"
                     /db_xref="MGI:MGI:2387176"
ORIGIN      
        1 mssaysvrsf pvsipavime tdwtepwllg llafhllcll ltcfssqryk lqighflclv
       61 vlvysaeyin evaavnwrlf skyqyfdsrg mfislvfsap llfnamlivi mwvrktltvm
      121 tdlktlqeer kerrrrrkee
//
