LOCUS       NM_026516               1696 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 178 (Tmem178), mRNA.
ACCESSION   NM_026516
VERSION     NM_026516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Khanna,K., Yan,H., Mehra,M., Rohatgi,N., Mbalaviele,G.,
            Mellins,E.D. and Faccio,R.
  TITLE     Tmem178 Negatively Regulates IL-1beta Production Through Inhibition
            of the NLRP3 Inflammasome
  JOURNAL   Arthritis Rheumatol 76 (1), 107-118 (2024)
   PUBMED   37534578
  REMARK    GeneRIF: Tmem178 Negatively Regulates IL-1beta Production Through
            Inhibition of the NLRP3 Inflammasome.
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Mahajan,S., Decker,C.E., Yang,Z., Veis,D., Mellins,E.D. and
            Faccio,R.
  TITLE     Plcgamma2/Tmem178 dependent pathway in myeloid cells modulates the
            pathogenesis of cytokine storm syndrome
  JOURNAL   J Autoimmun 100, 62-74 (2019)
   PUBMED   30879886
  REMARK    GeneRIF: data identify a novel Plcgamma2/Tmem178 axis as a
            modulator of inflammatory cytokine production by
            monocytes/macrophages.
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Decker,C.E., Yang,Z., Rimer,R., Park-Min,K.H., Macaubas,C.,
            Mellins,E.D., Novack,D.V. and Faccio,R.
  TITLE     Tmem178 acts in a novel negative feedback loop targeting NFATc1 to
            regulate bone mass
  JOURNAL   Proc Natl Acad Sci U S A 112 (51), 15654-15659 (2015)
   PUBMED   26644563
  REMARK    GeneRIF: Tmem178 localizes to the ER membrane and regulates
            RANKL-induced Ca(2+) fluxes, thus controlling NFATc1 induction
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Albert,Y., Whitehead,J., Eldredge,L., Carter,J., Gao,X. and
            Tourtellotte,W.G.
  TITLE     Transcriptional regulation of myotube fate specification and
            intrafusal muscle fiber morphogenesis
  JOURNAL   J Cell Biol 169 (2), 257-268 (2005)
   PUBMED   15837802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163903.4, BX511370.1 and AC165966.3.
            
            On Feb 7, 2007 this sequence version replaced NM_026516.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014196.1, AK013110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AC163903.4         18976-19367         c
            393-911             BX511370.1         1-519
            912-1696            AC165966.3         96956-97740
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.97 cM"
     gene            1..1696
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /note="transmembrane protein 178"
                     /db_xref="GeneID:68027"
                     /db_xref="MGI:MGI:1915277"
     exon            1..457
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..951
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /note="transmembrane protein 178A"
                     /codon_start=1
                     /product="transmembrane protein 178A precursor"
                     /protein_id="NP_080792.2"
                     /db_xref="CCDS:CCDS37705.1"
                     /db_xref="GeneID:68027"
                     /db_xref="MGI:MGI:1915277"
                     /translation="MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCE
                     RSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAE
                     CGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLT
                     KTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTG
                     IFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSWSIFCAWCSLGFIVAAGGLCI
                     AYPFISRTKIAHLKSGRDSTV"
     exon            458..571
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /inference="alignment:Splign:2.1.0"
     exon            572..709
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1696
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /note="hexamer: ATTAAA"
     polyA_site      1692
                     /gene="Tmem178"
                     /gene_synonym="2810417M05Rik; Tmem178a"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtgtc tggcggcggc ggcgagccca ccggcggcgg ctgctggccg ggaagccatg
       61 gagccacggg cgctcgtcac ggcgctaagc ctcggcctca gcctttgctc cctggggctg
      121 ctcgtcacgg ccatcttcac cgaccactgg tacgagaccg acccccggcg ccacaaggag
      181 agctgcgagc gcagccgcgc gggcgccgac cccccggatc agaagaaccg cctgatgccg
      241 ctgtcgcacc tgccgctgcg ggactcgcct cccctggggc gccggctgct ccccggcggc
      301 cccgggcgct cagaccctga gtcctggcgc tcgcttctgg ggcttggcgg gttggacgct
      361 gagtgtggcc ggccactgtt cgccacctac tcgggcctct ggaggaagtg ctactttctg
      421 ggcatcgacc gggacatcga caccctcatc ctgaaaggta ttgcacagcg atgcacagca
      481 atcaagtacc acttttctca gccaatccgc ttaagaaaca ttcctttcaa tttaaccaag
      541 acaatccagc aagatgaatg gcacctgctt catctaagaa gaataacagc tggcttcctg
      601 ggcatggcgg tggctgtcct gctgtgtggc tgcattgtgg ccacggtcag cttcttctgg
      661 gaggaaagcc tgacccagca cgtggccgga ctcctattcc tcatgacagg gatattttgc
      721 accatctcgc tctgcacgta cgccgccagt gtctcctatg acttgaaccg ggtcccgaag
      781 ctaatttaca gcctgcctca tgatgtggaa catggctaca gctggtccat cttttgtgcc
      841 tggtgcagtt taggttttat cgtggcagct ggaggtctct gcatcgctta tccgtttatt
      901 agccggacga agattgcaca tctaaagtct ggcagggact ccacggtatg acggtctgca
      961 ccgaagaagg cccagctaca gagcagagca gcagagtggg tctgagttcc attaggagca
     1021 gaactgagtt cacatcaggg ttccaagcac aaagaggtct tttacattcc aacctgttgc
     1081 ctgcagccct ttccggatga ctgacaggaa accctgcaga acttcccgac cttccgaagg
     1141 acaagacaac tgtgggttca agtgctttac tgacaatgct ctgattgggc gaagggaaga
     1201 attgcactgc aggacatttg taggcatcaa aaaagaggaa cggcgatgga aaaaaatttg
     1261 tatggtttcc atttatttca gaaagtttgt atatatcgat taccagagag tcgtttctat
     1321 ttgcaagagg attcataaca aaacgagtat aattttcttg tcactgtgcc aggcttgttg
     1381 gattttaatg cagcatcttc agaactcgtc ctgatggtgt cttgttgtgt cagcacctga
     1441 gatctgtgca ttatttgtga atgttccttg tcacaagagg attctccttc tgttgcctta
     1501 ttattacttt tcatgaattg aagtccacgc tctgtctttg tcctggagtt caaacgcgta
     1561 agaaaaacag accaaccatg taagagctga tccgtaaggc taggcagcag cattgtttga
     1621 agtcttctct gttgtttggc ttgtgtctct ttgttaactg gattctgcat taaatgactg
     1681 cccccttgtt aattta
//
