LOCUS       NM_001164207            1421 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus transmembrane protein 176B (Tmem176b), transcript
            variant 2, mRNA.
ACCESSION   NM_001164207
VERSION     NM_001164207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Jiang,L., Yang,Y., Liu,F., Ma,M., Gao,J., Sun,L., Chen,Y., Shen,Z.
            and Wu,D.
  TITLE     A Potential Diagnostic and Prognostic Biomarker TMEM176B and Its
            Relationship With Immune Infiltration in Skin Cutaneous Melanoma
  JOURNAL   Front Cell Dev Biol 10, 859958 (2022)
   PUBMED   35399535
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Lancien,M., Bienvenu,G., Salle,S., Gueno,L., Feyeux,M., Merieau,E.,
            Remy,S., Even,A., Moreau,A., Molle,A., Fourgeux,C., Coulon,F.,
            Beriou,G., Bouchet-Delbos,L., Chiffoleau,E., Kirstetter,P.,
            Chan,S., Kerfoot,S.M., Abdu Rahiman,S., De Simone,V., Matteoli,G.,
            Boncompain,G., Perez,F., Josien,R., Poschmann,J., Cuturi,M.C. and
            Louvet,C.
  TITLE     Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC
            Class II Antigen Presentation to Naive CD4+ T Cells
  JOURNAL   J Immunol 207 (2), 421-435 (2021)
   PUBMED   34233909
  REMARK    GeneRIF: Dendritic Cells Require TMEM176A/B Ion Channels for
            Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells.
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Segovia,M., Russo,S., Jeldres,M., Mahmoud,Y.D., Perez,V.,
            Duhalde,M., Charnet,P., Rousset,M., Victoria,S., Veigas,F.,
            Louvet,C., Vanhove,B., Floto,R.A., Anegon,I., Cuturi,M.C.,
            Girotti,M.R., Rabinovich,G.A. and Hill,M.
  TITLE     Targeting TMEM176B Enhances Antitumor Immunity and Augments the
            Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome
            Activation
  JOURNAL   Cancer Cell 35 (5), 767-781 (2019)
   PUBMED   31085177
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Lowe,M., Lage,J., Paatela,E., Munson,D., Hostager,R., Yuan,C.,
            Katoku-Kikyo,N., Ruiz-Estevez,M., Asakura,Y., Staats,J., Qahar,M.,
            Lohman,M., Asakura,A. and Kikyo,N.
  TITLE     Cry2 Is Critical for Circadian Regulation of Myogenic
            Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1
            and Tmem176b
  JOURNAL   Cell Rep 22 (8), 2118-2132 (2018)
   PUBMED   29466738
  REMARK    GeneRIF: myogenic differentiation is achieved through the specific
            interaction between Cry2 and Bclaf1, which stabilizes mRNAs
            encoding cyclin D1, a G1/S phase transition regulator, and
            Tmem176b, a transmembrane regulator for myogenic cell fusion.
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Anderson,M.G., Smith,R.S., Hawes,N.L., Zabaleta,A., Chang,B.,
            Wiggs,J.L. and John,S.W.
  TITLE     Mutations in genes encoding melanosomal proteins cause pigmentary
            glaucoma in DBA/2J mice
  JOURNAL   Nat Genet 30 (1), 81-85 (2002)
   PUBMED   11743578
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Lurton,J., Rose,T.M., Raghu,G. and Narayanan,A.S.
  TITLE     Isolation of a gene product expressed by a subpopulation of human
            lung fibroblasts by differential display
  JOURNAL   Am J Respir Cell Mol Biol 20 (2), 327-331 (1999)
   PUBMED   9922225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115045.13, AK007408.1, DV047496.1 and BE457679.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 through 6 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156042.1, AK007408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AC115045.13        38231-38581
            352-821             AK007408.1         7-476
            822-878             DV047496.1         510-566
            879-1338            AK007408.1         534-993
            1339-1421           BE457679.1         2-84                c
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.75 cM"
     gene            1..1421
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /note="transmembrane protein 176B"
                     /db_xref="GeneID:65963"
                     /db_xref="MGI:MGI:1916348"
     exon            1..379
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     exon            380..573
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1179
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /codon_start=1
                     /product="transmembrane protein 176B"
                     /protein_id="NP_001157679.1"
                     /db_xref="CCDS:CCDS20116.1"
                     /db_xref="GeneID:65963"
                     /db_xref="MGI:MGI:1916348"
                     /translation="MVQSTVTVNGVKVASTHPQSAHISIHIHQKSALEQLLGAVGSLK
                     KFLSWPQARIHYGQLSLGVTQILLGLVSCALGVCLYFGPWTELCAFGCAFWSGSVAIL
                     AGVGTIVHEKRQGKLSGQVSCLLLLACIATAAAATVLGVNSLIRQTSVPYYVEIFSTC
                     NPLQSSMDPGYGTVRYSDDSDWKTERCREYLNMMMNLFLAFCIMLTVVCILEIVVSVA
                     SLGLSLRSMYGRSSQALNEEESERKLLDGHPAPASPAKEKIPAIL"
     exon            574..684
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     exon            685..741
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     exon            742..972
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1092
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1421
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1379..1384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /note="hexamer: GATAAA"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /note="hexamer: AATAAT"
     polyA_site      1405
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
                     /note="major polyA site"
     polyA_site      1421
                     /gene="Tmem176b"
                     /gene_synonym="1810009M01Rik; Clast1; Lr8"
ORIGIN      
        1 actggagagc tggagaaggt gggcgaggta agagctgggg ttggcactga ttgttcctgt
       61 ggaatccttt gattgcacag tgctctctct cccagtcagg gatagagctt tctgagcagg
      121 tgctggcctg tgccaccttg ggtgtatgag tgtatctgtg tcacctgtat ccctgctcca
      181 gcaggcctga tcatctactc ctgatggacc cccctcaagt ggggcccttt cctgtcagct
      241 acttgctggc aaactgagag actccatgtc aggccccatc cctccacccc cttcttgctc
      301 tcctctctct ggggtcagct ttaagccagc tcctcccaga cctctcagtt ccagccccac
      361 ccatcgcaga ggacagcagc aggaaagatg gtccagagca cagtgactgt gaatggagtc
      421 aaagtggcct ccacacatcc ccagtccgct cacatcagca tccacatcca ccaaaaatct
      481 gctttggagc agctgctggg agctgtgggc tccctgaaga agtttctctc ctggcctcag
      541 gccagaatcc actatgggca gctgtctcta ggggtgaccc agatattgct ggggcttgtg
      601 agctgtgctc ttggagtatg tctctacttc gggccttgga ctgagctgtg cgcctttggc
      661 tgtgctttct ggtcggggtc tgtggcaatt ctagctggag ttggtactat tgtccatgag
      721 aagaggcagg gaaaactgtc cggccaggta tcatgtctcc tcctcctggc ttgcattgcc
      781 acagctgcag ctgctaccgt tctgggtgtg aacagcttaa tcaggcaaac cagtgttccc
      841 tactacgtcg agatcttttc cacatgcaac cccttgcaat caagcatgga ccctgggtat
      901 gggacagtgc gatacagtga tgattcagac tggaagacag agaggtgcag agagtacctg
      961 aacatgatga tgaacttgtt cctagcgttc tgcatcatgc tcacagtggt ctgtatcctg
     1021 gagattgttg tgtctgtggc ttccctggga ctaagtctcc gaagtatgta tggccggagc
     1081 tcccaggccc tgaatgaaga agagtcagag aggaagcttc ttgatgggca tccagcacct
     1141 gcgtccccgg ccaaagagaa gatccctgct atcctgtgat ccgcccacac ccacgtgtcc
     1201 ctgtccatag taatccaggg aggacgcgac tgttcccagg gcctcttctg gccccgcagc
     1261 acacacctac ttctgatgta gccactattc agccctcttt ctctccctct ctccccactg
     1321 tcctcacgcc aatgtccttt cttccacgaa cagatattat gtcattttat ccaatgccga
     1381 taaaggagaa acaacttgaa aataataccc tctcacagaa a
//
