LOCUS       NM_026685               2252 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 174 (Tmem174), mRNA.
ACCESSION   NM_026685 XM_127484
VERSION     NM_026685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Miyazaki-Anzai,S., Keenan,A.L., Blaine,J. and Miyazaki,M.
  TITLE     Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in
            Mice Causes Hyperphosphatemia and Vascular Calcification
  JOURNAL   J Am Soc Nephrol 33 (8), 1477-1486 (2022)
   PUBMED   35459732
  REMARK    GeneRIF: Targeted Disruption of a Proximal Tubule-Specific TMEM174
            Gene in Mice Causes Hyperphosphatemia and Vascular Calcification.
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Sasaki,S., Shiozaki,Y., Hanazaki,A., Koike,M., Tanifuji,K., Uga,M.,
            Kawahara,K., Kaneko,I., Kawamoto,Y., Wiriyasermkul,P., Hasegawa,T.,
            Amizuka,N., Miyamoto,K.I., Nagamori,S., Kanai,Y. and Segawa,H.
  TITLE     Tmem174, a regulator of phosphate transporter prevents
            hyperphosphatemia
  JOURNAL   Sci Rep 12 (1), 6353 (2022)
   PUBMED   35428804
  REMARK    GeneRIF: Tmem174, a regulator of phosphate transporter prevents
            hyperphosphatemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Chen,H., Palmer,J.S., Thiagarajan,R.D., Dinger,M.E., Lesieur,E.,
            Chiu,H., Schulz,A., Spiller,C., Grimmond,S.M., Little,M.H.,
            Koopman,P. and Wilhelm,D.
  TITLE     Identification of novel markers of mouse fetal ovary development
  JOURNAL   PLoS One 7 (7), e41683 (2012)
   PUBMED   22844512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131187.4 and AK002365.1.
            
            On Aug 15, 2009 this sequence version replaced NM_026685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057630.1, BC030878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC131187.4         68463-68536
            75-1459             AK002365.1         2-1386
            1460-2252           AC131187.4         70103-70895
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 52.11 cM"
     gene            1..2252
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /note="transmembrane protein 174"
                     /db_xref="GeneID:68344"
                     /db_xref="MGI:MGI:1915594"
     exon            1..716
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..822
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /codon_start=1
                     /product="transmembrane protein 174"
                     /protein_id="NP_080961.1"
                     /db_xref="CCDS:CCDS26715.1"
                     /db_xref="GeneID:68344"
                     /db_xref="MGI:MGI:1915594"
                     /translation="MEHSSNRPEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSG
                     IFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCS
                     DNEERVPDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMNATYLQPM
                     MNPCGLIPPSGAAAAAPSPPQYYTIYPQDNAAFVESEGFSPFVGTGYDRPDSDADQLE
                     GTELEEEDCVCFSPPPYEEIYALPR"
     exon            717..2252
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1447..1452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1469
                     /gene="Tmem174"
                     /gene_synonym="0610009B10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcccaaaggt ccttctctaa ctaaccggag cctgtgttcc ccactctcac actctgtttc
       61 ctctcatgtt ggacagtcgt gtgaggagct atggagcaca gcagtaatcg cccagaggac
      121 ttcccgctta acgtgttctc tgtcactccg tacacaccca gtaccgccga catccaggtg
      181 tccgacgacg acaaggcagg ggccactttg cttttctcag gcatctttct aggactggtg
      241 gggatcactt tcactgtcat gggctggatc aaataccaag gtgtctccca ctttgaatgg
      301 acccagctcc tcggacccat ccttctgtcg gtcggagtga cattcatcct gatcgctgtg
      361 tgcaaattca aaatgctatc ctgccagttg tgctcagata acgaggagag ggtcccggac
      421 tcggaccaga cttccggagg acagtcgttc gttttcactg gcatcaatca gcccatcacc
      481 ttccacgggg ccaccgtggt gcagtatatc cctcctcctt acggttctca ggagcccctg
      541 ggaatgaacg ccacctacct gcaacccatg atgaatcctt gcggtctcat acctcctagc
      601 ggagcagcgg ctgccgcacc aagtccccct cagtactaca ccatctaccc tcaagacaat
      661 gctgcgttcg tggagagtga gggcttctct cctttcgtgg gcactggata tgacaggccc
      721 gactctgatg ctgaccagct agaagggacg gagttggaag aggaggactg cgtatgtttc
      781 tctcctccac cgtatgagga gatatacgct ctacctcgct agagactgca atgctaaggg
      841 gacggacatt taagccctgt gatgtgatac ttggagagtt tatcgctgtg ttcttcagaa
      901 gttaggtgtc aaagcagctc aggagatctt acagatgtca ttcaaggtgg gaaagaagtg
      961 ccccgagact gctaaattaa gctgccctgg ttaaattccc ctctgctctg gttttgaatt
     1021 ctctcagcta agaaaccctc tgcagctgga gagtcgctct gtgatagagt gattttggag
     1081 cccacgcagt gccttgggtt tgatctctag agccagaaga aaacaaaaac aaaaacaaaa
     1141 acaaaacaag acctctctac ataaagtgca ggaggaaaat tcacccattt ccccatcccc
     1201 cacccgatat ccatttgaag gatatcttag ttttgaaaga ttgtcttagt tttaaatccg
     1261 gcagccatgg cagctctcag actgatgaaa gggaggctgg caagcaagca gggaagagag
     1321 caggctcagg tagaaatttc cctgcacggc gctgaacctt ccgcagcaga gtgacttatc
     1381 ttagacaact tgggctgtta tctggtctcc ctggaagcct ttggatcttg aagagtttgt
     1441 aaaagaaata aaatccatta agaaataaat gaataagtag agtgggatga aacagtgccc
     1501 catgttagaa tagtgttggg tggccgatcc tactgtggac gaggtaacag gaggataatg
     1561 aatgtcacca tgtgctgtcc accgagttac agtgacccct gctcctgatg gttttccttt
     1621 gcaaggctga agttcaaggc gtaatgtaca tgggtgagcg cctgctccct ctgcccaccc
     1681 ccaggctgtg attcccaggc acgaactagc tcagccgagt ggcttacaga acacaggtac
     1741 agctgagtgg cttatggaac acaggtatgc ctctaatctg ttccacagag ccatgctgcc
     1801 gtgtcgcttt gtagtcatga atcatggaga tgatcagtca tcccgtctcc cccacccccc
     1861 gcccccgggc gtagctctca ccttcatttg aacaaagaaa agctggtagc cttcagcttc
     1921 ctaagtctga acggtgtcac caaccacagc ccaaagctgc agactttagg aggtgtccaa
     1981 agaattagaa agaaaacagt tttacaaaga tcaaaggcca ctcaaggtaa aggtggctgc
     2041 ccccaagaga gatacaggaa ttgtcaggtc ttgaaggttt tggtactgtg cttatatgtg
     2101 ggattgcttt tactctctgt cagaagagtc caggtttttc aaggatatca gcaaaacaat
     2161 cttggtttat tattgtgatt catattatgc ctcagggaca tttcacttgg atgataacta
     2221 gtaataaaaa actagacatg tctatactca gt
//
