LOCUS       NM_001163572            7501 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 170B (Tmem170b), transcript
            variant 1, mRNA.
ACCESSION   NM_001163572 XM_886379 XM_913065
VERSION     NM_001163572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154848.2 and AC133159.3.
            
            On Feb 15, 2019 this sequence version replaced NM_001163572.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927936.1983703.1,
                                           SRR10662773.996656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AC154848.2         11202-11632         c
            432-602             AC133159.3         108002-108172       c
            603-7501            AC133159.3         94796-101694        c
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.55 cM"
     gene            1..7501
                     /gene="Tmem170b"
                     /gene_synonym="EG621976"
                     /note="transmembrane protein 170B"
                     /db_xref="GeneID:621976"
                     /db_xref="MGI:MGI:3647046"
     exon            1..431
                     /gene="Tmem170b"
                     /gene_synonym="EG621976"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..733
                     /gene="Tmem170b"
                     /gene_synonym="EG621976"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 170B isoform 1"
                     /protein_id="NP_001157044.1"
                     /db_xref="CCDS:CCDS49248.1"
                     /db_xref="GeneID:621976"
                     /db_xref="MGI:MGI:3647046"
                     /translation="MRAEGADHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALF
                     SSLFVHGAAGVLMFVMLQRHRQGRVISIIAVSIGFLASVTGAMITSAAVAGIYRVAGK
                     NMAPLEALVWGVGQTVLTLIISFSRILATL"
     exon            432..602
                     /gene="Tmem170b"
                     /gene_synonym="EG621976"
                     /inference="alignment:Splign:2.1.0"
     exon            603..7501
                     /gene="Tmem170b"
                     /gene_synonym="EG621976"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgttggc tacccaaagg ccgagcggca ggcgggcggc aggtgccgcg gccgggcgcc
       61 gctgcctcgt cgcgcgtccc cgcgatgagc ctcgtctcgc ggcctgcccc tgccggctgc
      121 cgctccgcgc gggcctcacg gcgtgacccg ggcctcgtgg cgtggcgggc ccccgcggcg
      181 cgacgcgggc cctgagcggg agcggcggtc cctcccgcgg ccccaggcct cgcccgccag
      241 cgctcctcga tgtctccccg gcggggagga cgctgcctgc gacacccgcc gagcggcgcc
      301 ccccggagcg ccccgctgcc gccccgcggg gacgatgagg gcggagggcg ccgaccactc
      361 gatgatcaac ctgtcggtgc agcaggtcct gagcctctgg gcccatggca cggtgctgag
      421 gaacctcacg gagatgtggt actggatctt cctctgggct ctcttctcct ctctgtttgt
      481 ccacggtgct gcaggcgtgc tgatgtttgt gatgctgcag aggcacaggc aggggagagt
      541 gatctccatc attgctgtca gcatcgggtt tctggcttct gtaactggag caatgattac
      601 tagtgcagca gtggccggca tctacagagt ggctgggaag aacatggccc cgctggaagc
      661 cctggtgtgg ggcgtggggc agactgtgct gacactcatc atctcctttt caaggatcct
      721 cgccacactc tgagttctga gggaatgtct tcttcactaa ggaaacgtgt ggacagagtc
      781 cccggaaatg tgtggttaat cagctgaaat gaagtggtac aagcagggac ccagcaagaa
      841 aaacctaggg aagaccttga gccgtgtggc aagcctgccc tctggcgtcc aaacgtttgc
      901 actaccgcac tgcaccttac gtgcctccat cccaggcaag gtgcacaaga ctctctgtga
      961 agctgcaaga agaagcacct tgtttagttg ccaatcaggt taacattggt gttgaaaccg
     1021 tcgttctcaa cggtgttgtg ttaagttaca ggaacgtttt gagaaattga tctatgtgcc
     1081 aaactttcct ttctgttaac attgatcatg tgacagtttg caagtgtaga cataggtgag
     1141 tgctgtgagt atacttgaca tggattcagg taacgtagcc aggcttagct ttgtcgtgtt
     1201 aatcccatga gtgttggata gtgggctttc aataccaagg atggtgttcg gtttgttaag
     1261 ctgagtgttc tggaacttgg ggctttaatc tgtctctgtg ttgttattta atttatgtga
     1321 aaaccactgg tctcctcagt ggacgactag ctgagctgtt ctatggactc agacttgtag
     1381 ggtgcatact tttcagtaac ctacaccttt catagtttcc ctcatatatc atattctatt
     1441 tatatggatc aaacctttat gagtcaaaca cattgtcact tgtgtgtcat aaaaatataa
     1501 tttacatttt tcttataaat tttgtaagga aaagtctaaa atgcatgttg cattcttcaa
     1561 cccttctaaa ggtttttgcc tccatctcac agaatattct aattcattgc agtgggattg
     1621 tgtgcactgt gtacgtgtct tgagtgtctt ggattctata gtactaactg cttagagagt
     1681 ggcctaaatt aggctctggg attaagaatg cttcatttat aggaaaataa taagtacctt
     1741 acataggaag agcagtaaac tgtctccctc tgtgtatgtg gcagggagaa aattacactt
     1801 gggaagactg aggactgagt ggatggtttt caagttggca gttagtctga gtgtatcaag
     1861 acaatgcaga acctttatct aagcggggat gttagcggtg tggtttaagt ttgtgattct
     1921 aagttattac ctgagtcgaa tagagtctca ggtcacattc attaacagtg gaaatgtact
     1981 ttgtttataa aaccttttag gaggtttaga aaaacacaca gttgtttatt acaaatacag
     2041 gaagttggga aagtacagac cctggttgaa ctgagtgtgt gtgtgtgtgt gtgtgtgtgt
     2101 gtgataacca gttgtaacta caaacgtgct aacttaaggg aagatccatt gtagaaatta
     2161 tgaatttata ggtaatctaa agaatagcat agcaccttga gctccttgac gtagtttggt
     2221 tgaagacgtt tattatccat gccccttttc cctaacagag aatgcattat cagtttcggg
     2281 aggagctgct ttgccagtgc atcagccaac ttagacttac taataacgtg gcttggaaat
     2341 ttaacaaccc aaaaatcaac caagaagcaa agctatatcc ttagagatgt cagagaacaa
     2401 gcctgaaatt gatttcttct gctgtgccca ggcctgctgc tcttcccatg cattctttgt
     2461 attcttgctg ttttctaaac ttaaacgtga gcatcttttc caggtaaccc cagttttctc
     2521 tcctgtttgg ctggctttgc tcttgtcagc aactcagagc tttgtgtgcc agcgtgagac
     2581 ttaactgtct ctgacattga cttgtgtaca gaacaaatat ttgtgttaac atggttatct
     2641 tatgatctga gaaagttatc atgttaaagt aatacggagc ccattgttca aatctaaaac
     2701 taactaaaga ttaccttgat acattgacta tgtgaatgaa tggaccaaag agaattgcgc
     2761 ttgttttgtg ctctagggtg aaagtctaag ggggttagtt acctctttag agactgtcct
     2821 gcggtcatct cattgtcaag ctaatttgca ttaagaattg tgttcatgtg tgcactttta
     2881 atttgatggg catttttagt ttcttcagtt atttccattg ggattttgtg taactatcaa
     2941 ctcttggtat tttgaaatgc aattgagtag tgtggattta tgaaactgtc tatatatcta
     3001 tttatatggt aaagttttca agaagctgtt tcttatagag acaaagtgtt taatgaaata
     3061 tatatatata tacacataag aatatcatta tatatacata tatagatagc tatatatgaa
     3121 tacagtccaa ttggaaagct ttgtttgatg aacattttcc tgttcttctg gagaagttga
     3181 tacatttgtt tggttaaatg ctctttgaaa tagactggag ggtatttaag ggtttgctgg
     3241 agacccttgt tttggatctg acaaaagctc tcactgacat agtcagttcc attttcttaa
     3301 aagctcagcc atggattagc agcacatttt cttccttagc accccatctc atgtgaccaa
     3361 gagcctgatc accatacagt tccatcagct tctcaggaga catggttaac tcaagtcctc
     3421 gtgtgtgtca gctcagccag tggtaaaggc ttacccagga ttctttctta gtattcgaaa
     3481 cacagaattc catggctcct tttctaagcc ttcaggagat tttttttttt tttttttttt
     3541 ttttggtgaa agaagggaaa ttaggtgtgt tgtgaagaac aaggataatt aagatctgag
     3601 gatgctatag aaaacagtgc ctccaggacc ttccattcac agcgtggaag gctgggcgcc
     3661 ctctttgaga tgcctaggct ggtactcacc acttagctca gtttgctgag ttctgttcta
     3721 tagatctcct gtgtacaaag atggctgaaa taggatttcc tcagactctc ccaggaactg
     3781 gacaagcagt ttcaaagtct aaaaaggttg gggtagtacc ttactacttc ctgagactca
     3841 ccctttctcc ctccccggac ctcatttttc tttttccatc tcatcctctg agttggacat
     3901 ttcaatgtct taggtgttgc tctgacaagg accagactct aagccaatga gatagatctg
     3961 agtccatgct ccgtcacgtg gttcactttg atctgagcat catttaacca ctctcagctt
     4021 taggtctcac tttgaattga ttaatacctc ctatgggtaa acagtatgtt tgtgacagta
     4081 agtcagtaga attctaaagt tatatttttc cataaccatt gggttttatg aaattcacct
     4141 tcatccattt cttttttttt ctatatattt taagaaaaaa gacttttata taattttact
     4201 ttcattacct cctctttgcc ccttaaaatc tacagataac ttttctaagg agactttgag
     4261 gagttgatgg tgatgggcgt gatgggtaaa taggaatata ttacaggttc tgctcacctc
     4321 tggttaatgt agagagaatg gatgtggcca gcatttcctc cactgccatt tcctacttgc
     4381 tccttttggt ttgactcaga acatcctttg actgggtccc atatgcaaag tactgccctc
     4441 gtattagctc ccgcccctcc tagtcatctg tcactgtgac gtaaagaata tggaaacatt
     4501 actgaggaat ttctgatgat ggctttagat tatagagaag tgtggtaaca tagcttaagt
     4561 atgactgggt agttactgaa tctttttaaa atcagggggc tgtattctca gtggttagac
     4621 ttgacagtca gccagtagtg tcctagttat ccataatttc tcatcctttg aaactgttca
     4681 ggatataaag gacattattc agttttaaaa tgtaatgttt cttgaatgtg caatgccatt
     4741 tgtaacagag agaaattcaa agtgggggat gttagagagg ctaatacaca aaacaagagc
     4801 atatgaaaac cccctgtgtt tgcaagcata gttcctccat cctgttaaga ccataaccac
     4861 catggagaga gaagtttgct catgccttgg ttcagtgtgt gtgggctcta caaaacacag
     4921 gtgctcatgg cacgttctgt ggggggattt gtcctccctt gaggatccct gttttctgta
     4981 ggtgatcctg tatggtggct tagtttctga atttgcctat cttagaatct agctggaatc
     5041 tgtttgggag aaattaatgt ttcctatgtg aaatgttttc aggaagcagg tgctgcactg
     5101 ctacaccttt ctgagcaagc tgagctggga tgcagtaccc tttcttcatt tagatccgct
     5161 ttcacattct ttacctacat gtggggcaca tgtattgaac acacataatg gccttttggg
     5221 ttttgcaaac taatatattt agcagtttct ctaacaatct cctttccaaa gcagatgtca
     5281 tacatcctaa cttagatgtg tgcatttctt gacagaagct gacgtgctgg tgtagagaga
     5341 ctgttcagtg cccatgttta tgctgtggtt atctcattga aaaggatgca ttcaaggcac
     5401 agggctgggg gtggggtagg cagagagtcc atgtgatgct cctgctctcc tttgcacgat
     5461 gtcctgcacc cacacctgct gtgtaggctc cgtgacacgg cctttccctt tggggaatgc
     5521 ctagctccat actctgatgc tgatcatctg gactcacccc atgagcggag cacttccctc
     5581 ctagacgtgc actggggatt cttttcaaga cattcacttg ttcagaggct tgagagcgcc
     5641 actgattgta aaggttttgg tttggtttgg ttgttgttgt tgtttttttt ttttaagttt
     5701 tatatttttg agatagagtc tcactctgta gcctagacta gctttgaact tgtgatcctt
     5761 ctgtctcagc ttgtcaggta ccaggattgc agatgtgtac cactgtgcat ggctcctcct
     5821 ttttaagtca aaaggtttac atttcatctc tgaaagtggt tagaatagaa tagttttaaa
     5881 gttttctttc tagaaagaaa aatactcttg tttgcctagg tttttttcat agtgcttatg
     5941 atagtagctg tgttttcctt ggggcactct tgctcttccc ctgtacacac ctttattcat
     6001 gagctccacc tgtttcatga acaagtagga cgctcccctc agctcattgt cgccatatga
     6061 tctggcagaa tgctcacccg tggttctagc ccaagtatta gcccctgcct taagatgtcc
     6121 caggatgaga gagcagcttt agttatatga taacatggct ttgtttaagt agcacaagta
     6181 taactgctct agcagatact aagaaactat cagccagccc actgatgaac catttagcta
     6241 aaccacagta taattttttt aaaaagctaa atgatatctc agggccttga aagttaagaa
     6301 tcttttgcaa agtggactta gggaggactg gggtttggcc aatgagctgg ctttgtgcac
     6361 agcacctgca gagagatccc agcacttaca gtgggccact gagacaagtc cagctactta
     6421 ccttttacag ttccggttcc gtagacatta gccactgact gtgacaggcc acaactgctt
     6481 ctacagtcct tcaccacacg ggggtatttg cctctccttc tttccctttc tttttttcca
     6541 agtaagtatg aaagtagaaa aatgtagaca aacaaatgtg ggattttaaa gttgagtttt
     6601 aggtaaacta gagattcctg tgtggacagt gttagtttaa tattgtagtt acaaaggcag
     6661 acactttatg taacctttag acatatgttt accatcaggg atttattttt acaatagaaa
     6721 tattaaatgt actgtgaagc ttaaagacag gaagactaga cgttggaggg tgatactcag
     6781 acaaaagtgt gtttggtgag gtacccgcgt tatgtgaaca tgacttcccc ttctgttaag
     6841 actataaact acactgtaag agtgtgtgtg ttgcatgttt acataaaaca atttcattct
     6901 gaaggattat ttcaactatg tttatatgta atacctaaca ggttgtaaat agtgtatact
     6961 attgattttt aattttatat gagcgatttt tttatttccc aagtcatgta caaatctcat
     7021 tgtgtatata gcataactcc ctggagacac aaattttgca gtgaatttta agtattttaa
     7081 tcgctgtaag catcatgtta gcctcagaga tgctggtcct tattttaaat tatttttcac
     7141 cacacatttt cttcaaaggg cagcaataaa catatgcaag ttattttggt tcttgaaagt
     7201 tggcctcaga agataagagt gcagttcaat tcacagctgt aaagaaaaga tgcacaactt
     7261 acaccatccg cgtctggtcc caggacaact tctgagatcc atctgcacat ggctctcctc
     7321 tttgtaatat acagggtgaa ctgttgaaaa cacacaggac atctgtcaca gtgaatccag
     7381 cacttcagtg tcattacaca gaatttattg gattaaagtt tgtaatatac agtattttaa
     7441 taaagtttct gtattcaatt tcatgcactt atatatataa ataaacctgt ctttaaaaac
     7501 t
//
