LOCUS       NP_083266                697 aa            linear   ROD 09-FEB-2025
DEFINITION  transmembrane protein 168 [Mus musculus].
ACCESSION   NP_083266
VERSION     NP_083266.1
DBSOURCE    REFSEQ: accession NM_028990.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 697)
  AUTHORS   Nguyen,L.K.C., Shimizu,A., Soh,J.E.C., Komeno,M., Sato,A. and
            Ogita,H.
  TITLE     Transmembrane protein 168 mutation reduces cardiomyocyte cell
            surface expression of Nav1.5 through alphaB-crystallin
            intracellular dynamics
  JOURNAL   J Biochem 170 (5), 577-585 (2021)
   PUBMED   34086898
  REMARK    GeneRIF: Transmembrane protein 168 mutation reduces cardiomyocyte
            cell surface expression of Nav1.5 through alphaB-crystallin
            intracellular dynamics.
            Erratum:[J Biochem. 2022 Mar 31;171(4):467. doi:
            10.1093/jb/mvab152.. PMID: 35137094]
REFERENCE   2  (residues 1 to 697)
  AUTHORS   Shimizu,A., Zankov,D.P., Sato,A., Komeno,M., Toyoda,F.,
            Yamazaki,S., Makita,T., Noda,T., Ikawa,M., Asano,Y., Miyashita,Y.,
            Takashima,S., Morita,H., Ishikawa,T., Makita,N., Hitosugi,M.,
            Matsuura,H., Ohno,S., Horie,M. and Ogita,H.
  TITLE     Identification of transmembrane protein 168 mutation in familial
            Brugada syndrome
  JOURNAL   FASEB J 34 (5), 6399-6417 (2020)
   PUBMED   32175648
REFERENCE   3  (residues 1 to 697)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139884.8 and AK051532.1.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051532.1, BC007160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.68 cM"
     Protein         1..697
                     /product="transmembrane protein 168"
                     /calculated_mol_wt=79543
     Region          17..695
                     /region_name="TMEM168"
                     /note="Transmembrane (TMEM) protein family 168; cd21494"
                     /db_xref="CDD:411069"
     Region          35..57
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            36..56
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          63..85
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            63..83
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            89..109
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          92..109
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            111
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          170..192
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            172..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          199..216
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            223..243
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          226..248
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Region          261..283
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            265..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            293..313
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          298..320
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            337
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            352..372
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Region          359..378
                     /region_name="putative TM helix"
                     /note="putative TM helix [structural motif]"
                     /db_xref="CDD:411069"
     Site            380..400
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            533
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91VX9.1)"
     Site            598
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91VX9.1)"
     CDS             1..697
                     /gene="Tmem168"
                     /gene_synonym="5730526F17Rik; 8430437G11Rik"
                     /coded_by="NM_028990.5:392..2485"
                     /db_xref="CCDS:CCDS19915.1"
                     /db_xref="GeneID:101118"
                     /db_xref="MGI:MGI:1921794"
ORIGIN      
        1 mcrslrycvs hclylamtrl eevnrevnmh ssvrylgyla rinllvaicl glyvrwekta
       61 nslilvifil glfvlgiasi lyyyfsmeaa slslsnlwfg fllgllcfld nssfksdvke
      121 ettkylllts ivlrilcalv erisgyvrhr ptllttvefl elvgfaiast tmlvekslsv
      181 illvmalaml iidlrmksfl aipnliifsv llffssletp qnpiafacff iclvtdpfld
      241 iyfsglsvte rwkpflhrgr icrrlsvlft amieltffil safklrdthl wyfvipgfsi
      301 fgffwmichi iflltlwgfh tklndchkvy inhradnnsl drimaskgmr hfcliseqlv
      361 ffsllatail gavswqptng iflsmflivl plesmahglf helgnclggt svgyaivipt
      421 nfcspdgqpt llppehvqel nlrstgmlna iqrffayhmi etygcdysts glsfdtlhsk
      481 lkaflelrtv dgprhdtyvl yysghthgsg ewalaggdil rldtllewwr ekngsfcsrl
      541 iiildsenst pwvkevrkin dqyvavqgae laktvdieea dppqlgdftr dwveyncnst
      601 nnicwtekgr tvravygvsk rwsdytlhlp tgsdvakhwm lhfprvtypl vhlanwlcgl
      661 nlfwvckacf rclkrlkmsw flptvldtgq gfklvks
//
