LOCUS       NM_011626               1896 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 165 (Tmem165), mRNA.
ACCESSION   NM_011626
VERSION     NM_011626.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Khan,S., Sbeity,M., Foulquier,F., Barre,L. and Ouzzine,M.
  TITLE     TMEM165 a new player in proteoglycan synthesis: loss of TMEM165
            impairs elongation of chondroitin- and heparan-sulfate
            glycosaminoglycan chains of proteoglycans and triggers early
            chondrocyte differentiation and hypertrophy
  JOURNAL   Cell Death Dis 13 (1), 11 (2021)
   PUBMED   34930890
  REMARK    GeneRIF: TMEM165 a new player in proteoglycan synthesis: loss of
            TMEM165 impairs elongation of chondroitin- and heparan-sulfate
            glycosaminoglycan chains of proteoglycans and triggers early
            chondrocyte differentiation and hypertrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Snyder,N.A., Palmer,M.V., Reinhardt,T.A. and Cunningham,K.W.
  TITLE     Milk biosynthesis requires the Golgi cation exchanger TMEM165
  JOURNAL   J Biol Chem 294 (9), 3181-3191 (2019)
   PUBMED   30622138
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Mizuno,S., Takami,K., Daitoku,Y., Tanimoto,Y., Dinh,T.T.,
            Mizuno-Iijima,S., Hasegawa,Y., Takahashi,S., Sugiyama,F. and
            Yagami,K.
  TITLE     Peri-implantation lethality in mice carrying megabase-scale
            deletion on 5qc3.3 is caused by Exoc1 null mutation
  JOURNAL   Sci Rep 5, 13632 (2015)
   PUBMED   26346620
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1896)
  AUTHORS   Reinhardt,T.A., Lippolis,J.D. and Sacco,R.E.
  TITLE     The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the
            developing, lactating and involuting mammary gland parallels the
            secretory pathway Ca(2+) ATPase (SPCA1)
  JOURNAL   Biochem Biophys Res Commun 445 (2), 417-421 (2014)
   PUBMED   24530912
  REMARK    GeneRIF: The timing, magnitude of TMEM165 expression and its Golgi
            location supports a role for this Golgi Ca2+/H+ antiporter as a
            contributor to mammary Golgi calcium transport needs, in addition
            to the better-characterized roles of SPCA1 and 2.
REFERENCE   7  (bases 1 to 1896)
  AUTHORS   Wilsbacher,L.D., Sangoram,A.M., Antoch,M.P. and Takahashi,J.S.
  TITLE     The mouse Clock locus: sequence and comparative analysis of 204 kb
            from mouse chromosome 5
  JOURNAL   Genome Res 10 (12), 1928-1940 (2000)
   PUBMED   11116088
REFERENCE   8  (bases 1 to 1896)
  AUTHORS   Antoch,M.P., Song,E.J., Chang,A.M., Vitaterna,M.H., Zhao,Y.,
            Wilsbacher,L.D., Sangoram,A.M., King,D.P., Pinto,L.H. and
            Takahashi,J.S.
  TITLE     Functional identification of the mouse circadian Clock gene by
            transgenic BAC rescue
  JOURNAL   Cell 89 (4), 655-667 (1997)
   PUBMED   9160756
REFERENCE   9  (bases 1 to 1896)
  AUTHORS   King,D.P., Zhao,Y., Sangoram,A.M., Wilsbacher,L.D., Tanaka,M.,
            Antoch,M.P., Steeves,T.D., Vitaterna,M.H., Kornhauser,J.M.,
            Lowrey,P.L., Turek,F.W. and Takahashi,J.S.
  TITLE     Positional cloning of the mouse circadian clock gene
  JOURNAL   Cell 89 (4), 641-653 (1997)
   PUBMED   9160755
REFERENCE   10 (bases 1 to 1896)
  AUTHORS   Akagi,J., Nomiyama,H., Setoyama,C., Shimada,K. and Akagi,M.
  TITLE     Messenger RNA expressed in mouse teratocarcinoma stem cells and
            down-regulated by a tumor-promoting phorbol ester codes for a novel
            transmembrane protein
  JOURNAL   Biochem Biophys Res Commun 157 (2), 548-557 (1988)
   PUBMED   3202867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB623818.1, M23568.1 and AA764070.1.
            
            On Aug 4, 2006 this sequence version replaced NM_011626.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M23568.1, BC141081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               BB623818.1         2-434
            434-1069            M23568.1           365-1000
            1070-1075           AA764070.1         23-28               c
            1076-1896           M23568.1           1007-1827
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 40.56 cM"
     gene            1..1896
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /note="transmembrane protein 165"
                     /db_xref="GeneID:21982"
                     /db_xref="MGI:MGI:894407"
     exon            1..473
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1238
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /note="TPA-regulated locus protein; transmembrane protein
                     PFT27; transmembrane protein TPARL; transmembrane protein
                     164; TPA regulated locus; putative divalent cation/proton
                     antiporter TMEM165"
                     /codon_start=1
                     /product="putative divalent cation/proton antiporter
                     TMEM165 precursor"
                     /protein_id="NP_035756.2"
                     /db_xref="CCDS:CCDS19359.1"
                     /db_xref="GeneID:21982"
                     /db_xref="MGI:MGI:894407"
                     /translation="MAAAARGSGRAPTRRLLVLLLLQLLWAPAGVRAGPEEDLSHRNQ
                     EPPAPAQQLQPQPAAVQGLEPARAEKGLTPVAPVHTNKEDAAAQTNLGFIHAFVAAIS
                     VIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALALMTCLSVLFGYATTVIPRVYTY
                     YVSTALFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPDVETG
                     TSTAIPQKKWLHFISPIFVQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGH
                     CLCTGLAVIGGRMIAQKISVRTVTIIGGIVFLAFAFSALFISPESGF"
     exon            474..699
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     exon            700..875
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1055
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1161
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1896
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
     polyA_site      1896
                     /gene="Tmem165"
                     /gene_synonym="pFT27; Tpardl; Tparl"
ORIGIN      
        1 aatgggaggt cgtgttggcc agggggcggg ccggaggagt tgggccgcgg aggcagttgg
       61 aggagtgtgt ggcttctgct gcccagctgc tccggagctc ccgccgccgg tccgtcccgg
      121 tccggtcccc gcgtcccgcg tgctgcaggg ctgccccctg agcggcagcc aggcctgacg
      181 gaggcgcctg ccggcacgcc gggctcgacg cttcccttcg cctgcacttc ttcctgccgc
      241 agcgcggtgc cggctgggcg ggcgggatgg cggccgcggc ccgggggagc ggccgggcgc
      301 cgacgcgaag gctgctcgtg ctcttgctgc ttcagttgct ctgggccccg gccggggtcc
      361 gcgccggccc ggaggaagac ctgagccatc ggaaccagga gccgccggcg cccgcccagc
      421 agctgcagcc gcagcccgcg gcggtgcagg gcctcgagcc ggcccgggcc gagaaaggat
      481 tgacaccagt cgccccagtt cataccaaca aagaagatgc agctgcccag acgaatctgg
      541 gatttatcca tgcgtttgtg gctgccatat cagtcatcat agtgtccgaa ctcggcgaca
      601 agacgttttt catagctgcc atcatggcga tgcgctataa ccggctgact gtgctggccg
      661 gggccatgct ggccttggcc ttgatgacat gcttgtcggt tttgtttggc tatgccacaa
      721 cagtcatccc cagggtgtat acatactatg tttcaactgc actcttcgcc atttttggca
      781 ttagaatgct tcgggaaggt ttgaagatga gcccagatga gggtcaggag gagctagaag
      841 aagtccaagc agagttaaag aagaaggatg aagaattcca acgaaccaaa ctcttaaatg
      901 ggccagatgt tgaaactggt acaagcacag caatacctca gaaaaagtgg ttacatttta
      961 tttcacccat ttttgttcaa gcgctcacat taacgttctt ggcagaatgg ggcgatcgct
     1021 ctcaactcac taccattgtc ctggcagcta gagaggaccc ttatggtgta gcagtgggtg
     1081 gcacagtggg acactgctta tgtactggat tggcagtaat tggaggaagg atgatagcgc
     1141 aaaagatctc tgtccgaact gtgacaatca tcggaggcat cgtatttttg gcgtttgcat
     1201 tttctgccct gtttataagt ccagagtctg gtttttaaca agctgttctt cagtattcag
     1261 cttaagatag gcaactcttt tctgtacata gtgtacatta caactaaaag taatgggaaa
     1321 cactgtattt tgtagcattg atttgtaagt ttgacccact taattattat gcccaaaaga
     1381 tataatcatt gattttattt gtaaagattt ttaaaaaggt ttgactccta agtgtgggtt
     1441 ctctctagct taattatgtt gacacctcag cctccacttc tgcttgatat acgcgtccac
     1501 tgaagtgagg ctgaccattg agttttcttg tagcatgacc cccttataaa cacgttttct
     1561 ccttggtcac tgggggttta atgtatacct taagcatttc cttggggaaa agaatgaatg
     1621 acttccactt ttaaaaccat attcctgagc cagtaatcag caattttatc ttgtctttgg
     1681 gaattaggat tgtatcaata acaaatgata agagttgctg gctaggccca ttctccctct
     1741 tatttttttt aattgggtag gacacccaat ataaaaatag tcaatatttg acaacatgga
     1801 cttaccaaat taaaagagaa tactatgaat gtattcatat ttttctatat tgaataagca
     1861 ttgtaacaaa caatgtaaat aaaaggtata actagt
//
