LOCUS       NM_001199360            5373 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus transmembrane protein 164 (Tmem164), transcript
            variant 1, mRNA.
ACCESSION   NM_001199360
VERSION     NM_001199360.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5373)
  AUTHORS   Su,Y., Li,L., Chen,J. and Gao,C.
  TITLE     TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD
  JOURNAL   Autoimmunity 57 (1), 2410192 (2024)
   PUBMED   39392409
  REMARK    GeneRIF: TMEM164 promotes ferroptosis by selectively mediating
            ATG5-dependent autophagosome formation to inhibit the progression
            of LUAD.
REFERENCE   2  (bases 1 to 5373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5373)
  AUTHORS   Zhang,L., Jia,Z., Wu,Q., Bai,T., Wang,B., Hu,X., Li,T., Liu,X.,
            Fu,J., Chen,Y., Ding,X., Liu,Z., Xu,Z. and Zhou,H.
  TITLE     Alleviating symptoms of neurodegenerative disorders by
            astrocyte-specific overexpression of TMEM164 in mice
  JOURNAL   Nat Metab 5 (10), 1787-1802 (2023)
   PUBMED   37679556
  REMARK    GeneRIF: Alleviating symptoms of neurodegenerative disorders by
            astrocyte-specific overexpression of TMEM164 in mice.
REFERENCE   4  (bases 1 to 5373)
  AUTHORS   Liu,J., Liu,Y., Wang,Y., Li,C., Xie,Y., Klionsky,D.J., Kang,R. and
            Tang,D.
  TITLE     TMEM164 is a new determinant of autophagy-dependent ferroptosis
  JOURNAL   Autophagy 19 (3), 945-956 (2023)
   PUBMED   35947500
  REMARK    GeneRIF: TMEM164 is a new determinant of autophagy-dependent
            ferroptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731678.17, CB525724.1, AL731674.9 and BF457004.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165910.1, SRR10223971.18951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL731678.17        164971-165184
            215-468             AL731678.17        165536-165789
            469-1059            CB525724.1         1-591
            1060-1060           AL731674.9         61118-61118
            1061-1122           CB525724.1         592-653
            1123-1125           AL731674.9         87613-87615
            1126-1204           CB525724.1         657-735
            1205-5356           AL731674.9         89278-93429
            5357-5373           BF457004.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..5373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 63.54 cM"
     gene            1..5373
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="transmembrane protein 164"
                     /db_xref="GeneID:209497"
                     /db_xref="MGI:MGI:2148020"
     exon            1..214
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     exon            215..873
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..1377
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="isoform a is encoded by transcript variant 1;
                     arachidonoyl ether phospholipid synthase"
                     /codon_start=1
                     /product="transmembrane protein 164 isoform a"
                     /protein_id="NP_001186289.1"
                     /db_xref="CCDS:CCDS30451.1"
                     /db_xref="GeneID:209497"
                     /db_xref="MGI:MGI:2148020"
                     /translation="MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVV
                     VLTLALLEILVALRHILRQKEDGRGGRSSQPQQVTQRPEEGKESLSKNLLLVALCLIF
                     GVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCPGATVIFKLQMHMLNGALLALL
                     FPVVNTRLLPFELEIYYIQHAMLYVVPVYLLWKGGAYTPEPLCNFQWALLSTGLMFFY
                     HFSFLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYM
                     AGPLCKYLLDLLRLPAKKID"
     exon            874..923
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     exon            924..990
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1069
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1170
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..5357
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5205..5210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="hexamer: AATAAA"
     polyA_site      5226
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="major polyA site"
     regulatory      5339..5344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="hexamer: ATTAAA"
     polyA_site      5357
                     /gene="Tmem164"
                     /gene_synonym="F730011B02"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctgggg ggctggtccg gagcaggcgg agggctgagg gtggcgctgg cccggagggc
       61 gggcgtgagg ggccaggggg ggtggagctg ggggttcggg ggtgtaccca ggggcgggag
      121 gctggaccgg gactgctcta aattggctgg agagggggcc ccgtcggcgg cgaagttgct
      181 agctgggggc agagacggcc acgcggttgc aggaattggc caacggctcc tttcaaccct
      241 gcctcgttgg tggccactgg agaagcgcgg ggggctcccc agacagccgt ggggacaagt
      301 tagagccagc actttatccc gggcctcgcg tgtagctttc cctcccctgt tctaggtgcc
      361 ccagtgtcca gaggggggtg cgggtgtgcc ctccttacat gttccaccgc ccgggcaacc
      421 cttcggtctc gtgttccatc tcgctcttgc ttcctgtacc gtagtcaagt ggagccactt
      481 tgcatcatgt cccggtatag ctaccaaagt ctcctggact ggctctatgg gggcgtcgac
      541 cccagttttg caggcaatgg gggccccgac tgtgctgcct tcctgtcttg gcagcagcgg
      601 ctgctggaaa gtgtggtggt cctgaccctg gccctgttgg agatcctggt ggccctgcgg
      661 cacatcctga ggcagaagga ggacggtagg ggtggccgta gcagccagcc acagcaggtg
      721 acccagcggc cagaggaagg caaggagagc ctgagcaaga atctgctctt agtagccctg
      781 tgcctgatct tcggggtgga ggtgggcttt aagttcgcca ccaagaccgt catctacctg
      841 ctcaaccctt gtcacctggt caccatgatg catatcttcc tcctggcctg tcccccatgt
      901 ccgggagcta ccgtcatctt caagttacag atgcacatgt tgaatggagc tcttctggca
      961 ttgctgttcc ccgtggtaaa tacccggctg ctcccctttg aactagagat ttactacatc
     1021 cagcatgcta tgctctacgt ggtccctgtc tacctgcttt ggaaaggagg tgcttacacc
     1081 ccagagcccc tctgcaattt ccagtgggct cttctctcga ctggcctcat gttcttttac
     1141 cacttcagct tcctgcagat cctcggcctg gtcaccgaag tgaatttgaa caacatgctg
     1201 tgtccggcca tctcagaccc attctacggc ccctggtatc gcatctgggc ctcgggacac
     1261 cagactctca tgaccatgac ccacgggaag ctggtcatcc tgttctcata catggctggg
     1321 cccttgtgta aatatctgct ggatttgctc cggcttccag ccaagaaaat agactaaagg
     1381 tgcttggggt tttgtttttg ttttagttct gtttgttttt ttgttttgtt tttgtttttg
     1441 tttttgtttt gttttgtttc ttcctgagga agcaaatcca gacttgactc agaatactca
     1501 gctcttgatg aaatcactgg agagggcaga tagagtgctt ggtttatttc ctttcccctc
     1561 ctctctggcc ctttcctcca ctactcttcc ttccccagct cctcccctcg gatgactctt
     1621 ggtacccagg gaaggtgctg ggggctggag cttactcctt ttccttccct gggttctggg
     1681 tcccttgtgt ggcccacccc gtctgcgtgg ccttacccag ggaaatggta gtcagcggcc
     1741 ccttccatac ggcttgtcgg tgcttttgac aacagccagt tgaggaaggg gaggacaacg
     1801 agcagtagtt cttccagcat cccagcaatg aagtagtgtt gggttcattt ctccactgcc
     1861 agggacctcc aggctcatgc tgggatcccc tttcatctcc agcatagccc cccaccagaa
     1921 ggggaccaag gccttgcttc tataccagcc gcaagcccag agccaaggga cttcccagtt
     1981 cacagccaaa atagattctt tcagtgactg gtgtcccatg actgaaagca gggagtcacc
     2041 cagccactcc ttctaaggga gctgcctggg gcggatgatg atagcagtgt gcagccaacg
     2101 gacaagattc tgtacagggg tgttagggat ctgttgccac agtgaatctc aagggaagat
     2161 gataaaggcg tacatagtac caggctggac gaccccccac cacagaaaac caaccaacct
     2221 tccctatgaa agctgagatt agatccacat ctaaaatgag catagaaatt aagaactcaa
     2281 ctaagtcaag tggcaacttg agaaagccac aatatgaatc acactctgca tcacatggat
     2341 aataggcagt gttctagtct cagctgaccc ggaaccatcc tcattgtctg tgtatgtgcc
     2401 tgtctgtttt tctgtctgag gcagcttcat ggaagaacga gctgggcttg gggcttgggt
     2461 gctgtttggc tgtttgtctt ttggctgttt gaaatggggg aaccgtcaca tttctcaaag
     2521 gtactctcga gccattcctg gcacttagga ggtgtgtcta tggttcctgg agggcgtttt
     2581 ctgagggtta gatttctctt gtgtagctcg actctgctga agtcgacatc actggttttg
     2641 aggcttgata gtgtccaaaa cccatatgta ggttgaaagg gaactctcag tggacctgag
     2701 gcccataggt tcaagtgttc tgaagggagg cgctttggtt ggaaggtact tggttatatg
     2761 tggaccacaa aggggaccag tgtctgtcta tctgctgact ccttgtcaac atctagtagg
     2821 aagagatttg cttgggaata gaaatgtttg taccatgagc accccaacgt ctcgtgccag
     2881 atgcagtatt caatgtgagt ttgtgggtat taggcctcag ctgaacttca gcagctcagt
     2941 ggccatgttt ctagacaatg gactttcagg gaaagtatct gcaggaaagc acacgggaac
     3001 tcagaggagc cattgtggga cgggctgcct ggccatgagg tgatcaagtc tgaggtactg
     3061 aaagcaggga agaactctag gcttgctgcc cttgagctcc tgtcctggca tcttcgcctt
     3121 ctgctgtctg tgagggctat gctgagcttc cctctctgac tcttcaggta ctgactcgcc
     3181 ctgcccactc atagaagttg gtggatgaat agcatgcagg gaagcctcct tggcctgggg
     3241 cttctctgta aggaggcatc ataggagggg agtccatgag gcccgaaaca tggagctgct
     3301 acctgcagcg gtggagggcc tcagcagagg ggaccaactc cagaatgtca tcgaggtggg
     3361 agtgccacac atactccttt cccatctgag gcttcatggt ccaggtcgcc ggtaatcttg
     3421 ggtttccctg cattggcctg cctttgcttt ggtgccagct cggtaggtat tttctggtgc
     3481 tcagaggaag agtggaaatc caaagccagg atacctggca tggccaagcc agagtcaaac
     3541 atacgtgtca ggaaagagga agtgaagggg acacgcaggg gtcgaggttg gctaaggaag
     3601 ctgaatgaaa cagattgtgg ctccttcaac agactccata gggaggctca gcctgggtgt
     3661 gagatgttgg ggagcagggg acctgtgaga tgttggggag caggggacct cttcactgtc
     3721 tatatatcgt ggtccaaacc tacatggcaa gaggtaacct gcctaggctc ttagcacttt
     3781 gctgtgggag ttgtccctag gtctgtccag agcctaccct ctactgcctg tggtacaggg
     3841 atggagaaga cagtatgcct tgacttggca gctcctcctc gggcctgtcg ttccctacca
     3901 gcatgtgtga gctctgggcc tgggcaagag tgctcagaga ggtgcctatc aggaaggaac
     3961 aaagtctctt caagccctaa ttgtccgtgg tcagggggct gcgccaataa gtacagttgg
     4021 ctaagccagt gtctctgctt agaggtcctt cctgccccca gtatttggtt ttgtgtatat
     4081 aagacttggc ccagcatctt ctcagaagcc ttgcagcatg gtcttctgtc atcctgtgac
     4141 atgctgtggg attggagagc cacctcctcc tcctctttaa gtctgtcttc tgtctttctg
     4201 tggacttctt tgtacctgtg ggggtggtct atggggtcta tgtgcacttt aatctatggt
     4261 gcctctggta ggggtttgct atatgtgatc atatgggtga ttcagtgttt catgatgtaa
     4321 ttacaagttt ctcatggata gctcagtgtc aacagtggaa ctggggctgg gtaatgtcct
     4381 gagctgggtg tttaggagat ggcaccgggc cccttttaac tctctgccaa atagacttcc
     4441 ctgggaattc tggcacctgt cctctttggg acaagggttt cttaatggtt tctactgtaa
     4501 gggaggccag aagcaggggg cgggggagga caagacatcg cttctggttt tttgtgagcc
     4561 aggaacaggt ttctctggca acttgggaag tccccagact aggaaggagc atcctgtctc
     4621 ctcctggtcc agctgtccct gaggtaaaag tccattagag gagtcagtct tcctctggta
     4681 tatgcagtgt gctcactgtg tgcaggaaga ccaagtggct tgctgttgcc ctcgtctgtg
     4741 acacttttgt acactgattt gccactcatg gcactgagca gacatccatc cctactcagt
     4801 gaaaaaccag tcaaaagcaa aagtcctttg aagcagaagt tgatgctttg gaaaactctt
     4861 gacttatttt ggtgtcaaca ttatgttaga tttgaaagca ttcttcgtgt atttgatgta
     4921 attgtagcga agagagcagg attgaatggt gttcagttat ttcttctggg acatggaaag
     4981 cctgtccccc atccttcttc tgaagccgag tctgctgtgt actgttaccc tcgagggagc
     5041 gcagggctct tctgagagcc ggtctctgaa ctgctgcttc tgggacatgc ttccccacct
     5101 cctccagtct acctcccctc ttggggtgtt tttgtaatgt gctttctctg ttttgtaaaa
     5161 tccctttgat tgtaatgaag tgggttctgc agccaccttt tggaaataaa tggtccttaa
     5221 attgtgtact tagcattttg aatcttagcc tcaggtgttt ctgctgttga agattcctga
     5281 atgaaaagaa accctcccca tgggacttat tgttacaatg ttttcttcat ttactgttat
     5341 taaaagattt atgagaaaaa aaaaaaaaaa aaa
//
