LOCUS       NM_175187               2704 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 161B (Tmem161b), transcript
            variant 1, mRNA.
ACCESSION   NM_175187
VERSION     NM_175187.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Smith,K.A., Dominado,N. and Briffa,J.F.
  TITLE     Fins, fur, and wings: the study of Tmem161b across species, and
            what it tells us about its function in the heart
  JOURNAL   Mamm Genome 34 (2), 270-275 (2023)
   PUBMED   37222785
  REMARK    GeneRIF: Fins, fur, and wings: the study of Tmem161b across
            species, and what it tells us about its function in the heart.
            Review article
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Akula,S.K., Marciano,J.H., Lim,Y., Exposito-Alonso,D., Hylton,N.K.,
            Hwang,G.H., Neil,J.E., Dominado,N., Bunton-Stasyshyn,R.K.,
            Song,J.H.T., Talukdar,M., Schmid,A., Teboul,L., Mo,A., Shin,T.,
            Finander,B., Beck,S.G., Yeh,R.C., Otani,A., Qian,X.,
            DeGennaro,E.M., Alkuraya,F.S., Maddirevula,S., Cascino,G.D.,
            Giannini,C., Burrage,L.C., Rosenfield,J.A., Ketkar,S., Clark,G.D.,
            Bacino,C., Lewis,R.A., Segal,R.A., Bazan,J.F., Smith,K.A.,
            Golden,J.A., Cho,G. and Walsh,C.A.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog
            signaling, and ciliary structure in the developing central nervous
            system
  JOURNAL   Proc Natl Acad Sci U S A 120 (4), e2209964120 (2023)
   PUBMED   36669111
  REMARK    GeneRIF: TMEM161B regulates cerebral cortical gyration, Sonic
            Hedgehog signaling, and ciliary structure in the developing central
            nervous system.
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Wang,L., Heffner,C., Vong,K.I., Barrows,C., Ha,Y.J., Lee,S.,
            Lara-Gonzalez,P., Jhamb,I., Van Der Meer,D., Loughnan,R.,
            Parker,N., Sievert,D., Mittal,S., Issa,M.Y., Andreassen,O.A.,
            Dale,A., Dobyns,W.B., Zaki,M.S., Murray,S.A. and Gleeson,J.G.
  TITLE     TMEM161B modulates radial glial scaffolding in neocortical
            development
  JOURNAL   Proc Natl Acad Sci U S A 120 (4), e2209983120 (2023)
   PUBMED   36669109
  REMARK    GeneRIF: TMEM161B modulates radial glial scaffolding in neocortical
            development.
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Koopman,C.D., De Angelis,J., Iyer,S.P., Verkerk,A.O., Da Silva,J.,
            Berecki,G., Jeanes,A., Baillie,G.J., Paterson,S., Uribe,V.,
            Ehrlich,O.V., Robinson,S.D., Garric,L., Petrou,S., Simons,C.,
            Vetter,I., Hogan,B.M., de Boer,T.P., Bakkers,J. and Smith,K.A.
  TITLE     The zebrafish grime mutant uncovers an evolutionarily conserved
            role for Tmem161b in the control of cardiac rhythm
  JOURNAL   Proc Natl Acad Sci U S A 118 (9) (2021)
   PUBMED   33597309
  REMARK    GeneRIF: The zebrafish grime mutant uncovers an evolutionarily
            conserved role for Tmem161b in the control of cardiac rhythm.
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Oliver,P.L., Chodroff,R.A., Gosal,A., Edwards,B., Cheung,A.F.,
            Gomez-Rodriguez,J., Elliot,G., Garrett,L.J., Lickiss,T., Szele,F.,
            Green,E.D., Molnar,Z. and Ponting,C.P.
  TITLE     Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding
            RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype
  JOURNAL   Cereb Cortex 25 (10), 3572-3585 (2015)
   PUBMED   25209608
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Thoren,L.A., Norgaard,G.A., Weischenfeldt,J., Waage,J.,
            Jakobsen,J.S., Damgaard,I., Bergstrom,F.C., Blom,A.M., Borup,R.,
            Bisgaard,H.C. and Porse,B.T.
  TITLE     UPF2 is a critical regulator of liver development, function and
            regeneration
  JOURNAL   PLoS One 5 (7), e11650 (2010)
   PUBMED   20657840
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY239899.1, BC051663.1 and BM899262.1.
            
            On Oct 21, 2009 this sequence version replaced NM_175187.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088393.1, SRR1660811.147544.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY239899.1         1-52
            53-2528             BC051663.1         1-2476
            2529-2704           BM899262.1         1-176               c
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 44.2 cM"
     gene            1..2704
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /note="transmembrane protein 161B"
                     /db_xref="GeneID:72745"
                     /db_xref="MGI:MGI:1919995"
     exon            1..139
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1600
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 161B isoform a"
                     /protein_id="NP_780396.2"
                     /db_xref="CCDS:CCDS36739.1"
                     /db_xref="GeneID:72745"
                     /db_xref="MGI:MGI:1919995"
                     /translation="MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPS
                     EEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFP
                     EYQWLVDFTVAATIVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYF
                     KVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLE
                     SQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNMATEKITQTLLHINFLA
                     PLFMVLLWVKPITKDYIMNPPLGRESVPLMTEATFDTLRLWLIILLCVLRLAMMRSHL
                     QAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHMTLLL
                     KTLGNHSWGIYPEAAFPLPVDNNLPANSAYPELPSPDGKMKVTVTQITVALSSLKNIF
                     TPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA"
     exon            140..243
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..327
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..425
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            426..582
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            583..734
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            735..795
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            796..936
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1050
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1225
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1322
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..2686
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /note="hexamer: AATACA"
     polyA_site      2590
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /note="major polyA site"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2686
                     /gene="Tmem161b"
                     /gene_synonym="2810446P07Rik"
ORIGIN      
        1 gggcaggact tccggccgag ccggaagacc tttcccttcg cggtttcgag agctccgttt
       61 tgcagaacct gaaggggaga ttctggacgg tcccggggac tctagactgt ctgtcccacg
      121 acctgttctt ggcgttatgg gtgtgatagg tatacagctg gttgttacca tggtgatggc
      181 cagtgtcatg cagaagatta tacctcacta ttctcttgct cgatggctac tctgtaatgg
      241 cagtttgaga tggtatcaac atccttccga agaagaatta agaatccttg cagggaagca
      301 gcagaaagga aaaagtaaaa aagacagaaa atacaatggc catattgaaa ataagccact
      361 aaccattcca aaagacattg accttcatct agaaaccaag tctgttacag aagtggacac
      421 tttagcactg cattacttcc cagaatacca gtggctggtg gacttcacgg tggctgctac
      481 cattgtctat ttagtaactg aggtctatta cagcttcatg aagcctacac aggaaatgaa
      541 tatcagctta gtttggtgcc tcctggtttt gtcttttgca atcaaagttc tattttcatt
      601 aactacacac tattttaaag tagaagatgg aggtgaaagg tcagtttgtg tcacctttgg
      661 attttttttc ttcgttaaag caatggcagt tttgatcgta acagagaact acctggagtt
      721 tggccttgaa acagggttta caaatttttc agacagtgca atgcagtttc ttgaaaagca
      781 gggtttagaa tctcagggcc ctgtttcaaa acttactttc aaatttttcc tggctgtttt
      841 ctgttcactc attggggctt ttttgacatt tcctggatta cggctggctc aaatgcatct
      901 ggatgccctg aatatggcaa cagaaaaaat tacacaaaca ttacttcata tcaacttctt
      961 ggcaccttta tttatggttc tgctctgggt gaaaccaatc accaaagact atatcatgaa
     1021 cccaccgttg ggtagagaga gtgtccctct aatgacagaa gccacatttg atactcttcg
     1081 actctggtta ataatcctgc tctgtgtttt gcggttggcc atgatgcgaa gtcacctgca
     1141 agcatattta aatttggccc agaaatgtgt ggatcaaatg aagaaagaag ctggccgaat
     1201 aagtacagtt gagctacaga aaatggtggc gcgagtcttt tactacctgt gtgtcattgc
     1261 cctgcagtat gtggcacctc tggtaatgct gcttcatatg actctgcttc tgaaaacact
     1321 aggtaatcat tcctggggaa tttatccaga agccgccttt cccttgccag tggataataa
     1381 tctccccgcc aactcggctt accctgaact accatcacct gatgggaaga tgaaggtaac
     1441 tgttacacaa atcacagtgg ccctgagcag cttaaaaaac atcttcacgc ctctcctttt
     1501 tcgaggactt ctgtcatttt tgacatggtg gattgcagct tgcctctttt ctacaagcct
     1561 ttttgggctt ttctatcatc agtatttgac agtggcatga atttcagtca aaaacggata
     1621 tccaagtcac actttaaatt caaatatctg tgcccttgaa ggattgacaa aagaagaatg
     1681 caaatagaac ggagaaaaaa attattggag tgttttgttt tgaatgcttc ctctgtactc
     1741 tcagggtgaa ttaatgttgt aatatttaaa actcatgaga taggttgtta cactgttaca
     1801 cactgtggca ttggaattgt aactcattga gagaactaat gtgagagggc tctctgcagg
     1861 ggtaatcctt ctgattatct tggtttacag ttgcaaacct ccaacagtct gttagacttc
     1921 ttctaggact ccagttactg actgcttttc atggtgttgt ggtactgtta ctactcatag
     1981 ttgctgccta cagaacaatc ttcaaactga gccatgctcg agggaaggga aaggaacgaa
     2041 aattacttct gttggtaatg tattagtctt aaaaaaaaat ccaacagaaa ggaagagaaa
     2101 gctactgtat attacagtaa gaaaagctgc atagtcattt taaattgaat ggagatataa
     2161 attacctatt gtctacaagt actgttactt gagagtagca ggaatattct tttaaagtga
     2221 atgccaccca gcttgaaagt tctttttaaa tgattggcca tatgaacatc agcggtctca
     2281 ctgttagttt tgggccttgc tgtattttat tttttctttg attttaaata gttatgttta
     2341 atctaaaaat atttatcaat actgatcaaa tttgagaatt actttgcaat cctgctgact
     2401 acgtgtatgt attgtgtata tattatatat taaatatata atatattgag gttataaaag
     2461 atgaaaatat tgaatcctta taatatttta agtttcagaa cgtacgttaa acaatgattt
     2521 gaatgagatg tatttgtatc tggaaatttc tgtttggaat gagattaaaa tacatttttt
     2581 taaagctcaa cagagtgtaa tttatttgtt gtacatatat gataatagta cttaaaatgt
     2641 catgaagatt agttgatttc tcacaaatta aatttcattt tctgttaaaa aaaaaaaaaa
     2701 aaaa
//
