LOCUS       NM_145597               3031 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus transmembrane protein 161A (Tmem161a), transcript
            variant 1, mRNA.
ACCESSION   NM_145597
VERSION     NM_145597.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Nagai T, Sekimoto T, Kurogi S, Ohta T, Miyazaki S, Yamaguchi Y,
            Tajima T, Chosa E, Imasaka M, Yoshinobu K, Araki K, Araki M,
            Choijookhuu N, Sato K, Hishikawa Y and Funamoto T.
  TITLE     Tmem161a regulates bone formation and bone strength through the P38
            MAPK pathway
  JOURNAL   Sci Rep 13 (1), 14639 (2023)
   PUBMED   37670024
  REMARK    GeneRIF: Tmem161a regulates bone formation and bone strength
            through the P38 MAPK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Xie X, Sun L, Duan Y, Lv Z, Yao X, Wang C, Chen X, Tian S, Yan L,
            Shao Y, Luo H and Liu J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Kurogi S, Sekimoto T, Funamoto T, Ota T, Nakamura S, Nagai T,
            Nakahara M, Yoshinobu K, Araki K, Araki M and Chosa E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Nakahara M, Tateyama H, Araki M, Nakagata N, Yamamura K and Araki
            K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082916.1, AK049979.1 and BF456501.1.
            
            [WARNING] On Dec 22, 2023 this sequence was replaced by
            NM_145597.5.
            
            On Jun 22, 2014 this sequence version replaced NM_145597.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147962.1, AK049979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK082916.1         2-4
            4-2997              AK049979.1         3-2996
            2998-3031           BF456501.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3031
                     /gene="Tmem161a"
                     /note="transmembrane protein 161A"
                     /db_xref="GeneID:234371"
                     /db_xref="MGI:MGI:2384577"
     exon            1..33
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1473
                     /gene="Tmem161a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="transmembrane protein 161A isoform 1 precursor"
                     /protein_id="NP_663572.1"
                     /db_xref="CCDS:CCDS40369.1"
                     /db_xref="GeneID:234371"
                     /db_xref="MGI:MGI:2384577"
                     /translation="MAVLGVQLVVTLFTATLMHRLAPHCSFARWLLCNGSLFRYIHPS
                     EEELRALSGKLRPRVRKERWANGLHDEKPLSVPRDAHFQLQTCPLTAVDALVLRFFLE
                     YQWFVDFAVYSVGVYLFTEAYYFVLGPVQETNIAVFWCLLTLAFSLKVFLMVTRLYFS
                     TKEGGERSVCLSFAFLFLLLAMLVQVVREETLELGLEPGLASMTQHLEPILKKQDWDW
                     TLPVIKLAIRLGLAVLGSLLGAFLIFPGLRLAQTHQDALTLSADRPLLQLLLHTSFLS
                     PLCTLWLWTKPVARDFLYQAPTRNMTFSVPSEGAFDSLRLWVLVALCLLRLAVTRPHL
                     QAYLCLAKARVEQLRKEAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLHCTLLL
                     KTLGGYSWALSSTPPPLAPSQPSEALIPVDPAGDEAQQTAAQVAGILGGLLTPLFLRG
                     MLAYIIWWTAACQLLSSLFGLYFHQHLAAS"
     exon            34..137
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            138..218
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            219..316
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            317..473
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            474..625
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            626..686
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            687..830
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            831..944
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1119
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1216
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..3015
                     /gene="Tmem161a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgtaccgc tgtgcgccca gggagcggac atggcggtcc ttggagtgca gctggtggtg
       61 actctgttca ccgccaccct catgcacagg ctagcgccac actgttcctt cgcacgctgg
      121 ctgctctgca atggcagtct gttccggtac atacacccgt cagaggagga acttcgggcg
      181 ctgtcaggga aactgaggcc ccgggtcagg aaggagcggt gggcaaatgg tcttcatgac
      241 gagaagccat tgtcagtgcc tcgagatgcc catttccagc tgcagacctg tcccctcact
      301 gctgtggatg ccctagtcct gcgcttcttt ctggaatacc agtggttcgt cgacttcgca
      361 gtgtactccg ttggtgtgta cctcttcaca gaggcctact attttgtgct gggcccagtc
      421 caggagacca acatcgctgt gttctggtgc ctgctcactc tggccttctc tctgaaggtg
      481 ttcctcatgg tgacccggct gtacttcagt accaaggagg gcggtgagcg ctccgtatgt
      541 ctctcctttg ccttcctctt cctcctcttg gccatgctgg tacaggtggt gcgggaggag
      601 accctggagc tgggcctgga gccgggccta gccagcatga cccagcacct ggagcctatt
      661 ctgaagaagc aggattggga ctggacactc cctgtgatca agttggccat ccgccttggg
      721 ctggcggtgc taggctccct gctgggcgcc ttcctcattt tccctggcct gaggctggcc
      781 cagacccacc aggacgcgct gaccctgtct gcggaccgac cactgctaca gctgctccta
      841 cacaccagct tcctgtcacc cctgtgcacc ttgtggctct ggacaaagcc tgtcgcccgg
      901 gacttcctgt accaggcacc cacaaggaac atgactttct ctgtaccgtc agaaggggct
      961 ttcgactctc tgcgcctctg ggtgttggtg gcgctgtgcc tgttgcgcct ggcagtaacc
     1021 cggccacacc tgcaggccta cctgtgcctg gccaaggctc gagtggagca gctgcgcaag
     1081 gaggctggcc gcattgaggc ccgtgaaatc cagcagcggg tggtccgggt ctactgctac
     1141 gtgactgtgg tgagcctgca gtacctgacc ccgctcatcc tcactctgca ctgcacactg
     1201 ctgctcaaga ccctgggagg ctactcttgg gccctgagct ctactcctcc cccactggcc
     1261 ccatcccagc cctcagaggc tttgatccct gtagaccctg caggagatga ggcccagcag
     1321 actgcagccc aggttgcagg gatcctgggt ggcctgctca cgcccctctt cctcagaggc
     1381 atgctggctt acatcatctg gtggacagct gcctgccagc tgctctccag cctcttcggc
     1441 ctctatttcc accagcacct ggcagcctct tagcaggaag gcactaggct ctagtgtctg
     1501 attcctgccc accaggattg ggactgttcc ctgtgtgtgt gccttggtgc ccctagatga
     1561 cataagggtt ggtgtgggga ctccctacca tctctctcac ttcagtgcct agatcataaa
     1621 ccccttgaag caatctcccc tgggccatga tccccaagtg tgtgtgtgtg gagggggcac
     1681 gttttacaga aatatcccag agactggggg atgagcaggg gagacctgga tagtgagagg
     1741 ggcctgggag agagtggaaa cctcaagatc agaggtggct aggagagcta ggggtgggac
     1801 tctggcccag catccatata gccccggcat ctgtcagtat ccccaggagg gagagacagt
     1861 agtctccatg cctgtctccc cagcacactt ggggaagctg aggtaagagg gttagcctag
     1921 actagtaaca agactatgta aaacaagaag aaaaaggggg ccgggggaag cttgaaaggg
     1981 aagagaggga agaggttgtc accatcctcc aaagctgtga ggatgactgc tgtgttttga
     2041 ggtcttggtg actaagggtc acctccaact ccaaagttat ttttttgcta tgacttagtg
     2101 tgtttacgtg tgtatttatg agatatgtgt gaccttccta catatgtaaa atgtgtattg
     2161 agaataaaaa aggagggctt ctgcaatgct gccttaccat ggtgccagtg tggtctggcc
     2221 cagtcatgtt caagagccag tgctcagtca gagccttgag cctctgggtc tctgtccaag
     2281 aggacttagg agtgtgactg cctatgtgct gtgaacacag gtgctgtgaa cacaggtgct
     2341 gtgtatgata caataggtcc atgtgtgaga gcagggatca gaggacaact tagcatgtag
     2401 atcctagcct tctactatga gacagggtct cttgtttacc tgagtccctc aggtcagctg
     2461 tccaacaggc tccagggagt ctctggtttc tgcttcccac cttgcttgta ggagtgctag
     2521 gattatagac tagtgctgct gtcccacttt atgtgggctc tggggacttg aactcaggtc
     2581 ttcatgactg cagcaaatat ggctgacgtg tgtgttatga atcaacagga tgtccttgaa
     2641 gggctatctg gagtccctgc ctcccaaact gaccctgaca agggctgcag gaccttgtgg
     2701 aagtctcatg ggaatcaggg atgcccatgc tctgctgtgg atttcagagt gtaggggcac
     2761 acgacgtaca gggccccacc tccttcagct acatggctca gggctgactg ggcctgagct
     2821 gtgtttcaga gcaaggtcct taggcttctg gccgatgccc atttgctgag catgatggag
     2881 tatagctgat gactccagag gtagttgggc cagccagtgc tatgcaagaa ctagaagcca
     2941 gcatggatta tatttctcag atattaaata aatccgagcc atgttgttgg cagatttagc
     3001 tacatggtta ctgtaaaaaa aaaaaaaaaa a
//
