LOCUS       NM_001382851            2804 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus transmembrane protein 150C (Tmem150c), transcript
            variant 1, mRNA.
ACCESSION   NM_001382851 XM_011249426
VERSION     NM_001382851.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2804)
  AUTHORS   Ojeda-Alonso,J., Begay,V., Garcia-Contreras,J.A.,
            Campos-Perez,A.F., Purfurst,B. and Lewin,G.R.
  TITLE     Lack of evidence for participation of TMEM150C in sensory
            mechanotransduction
  JOURNAL   J Gen Physiol 154 (12) (2022)
   PUBMED   36256908
  REMARK    GeneRIF: Lack of evidence for participation of TMEM150C in sensory
            mechanotransduction.
REFERENCE   2  (bases 1 to 2804)
  AUTHORS   Wee,J., Pak,S., Kim,T., Hong,G.S., Lee,J.S., Nan,J., Kim,H.,
            Lee,M.O., Park,K.S. and Oh,U.
  TITLE     Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion
            in pancreatic beta-cells
  JOURNAL   Cell Rep 37 (9), 110067 (2021)
   PUBMED   34852221
  REMARK    GeneRIF: Tentonin 3/TMEM150C regulates glucose-stimulated insulin
            secretion in pancreatic beta-cells.
REFERENCE   3  (bases 1 to 2804)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2804)
  AUTHORS   Lu,H.J., Nguyen,T.L., Hong,G.S., Pak,S., Kim,H., Kim,H., Kim,D.Y.,
            Kim,S.Y., Shen,Y., Ryu,P.D., Lee,M.O. and Oh,U.
  TITLE     Tentonin 3/TMEM150C senses blood pressure changes in the aortic
            arch
  JOURNAL   J Clin Invest 130 (7), 3671-3683 (2020)
   PUBMED   32484458
  REMARK    GeneRIF: Tentonin 3/TMEM150C senses blood pressure changes in the
            aortic arch.
REFERENCE   5  (bases 1 to 2804)
  AUTHORS   Hong,G.S., Lee,B., Wee,J., Chun,H., Kim,H., Jung,J., Cha,J.Y.,
            Riew,T.R., Kim,G.H., Kim,I.B. and Oh,U.
  TITLE     Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in
            Dorsal-Root Ganglion Neurons with Proprioceptive Function
  JOURNAL   Neuron 91 (1), 107-118 (2016)
   PUBMED   27321926
  REMARK    GeneRIF: TTN3 appears to be a component of a mechanosensitive
            channel with a slow inactivation rate and contributes to motor
            coordination. Identification of this gene advances our
            understanding of the various types of mechanosensations, including
            proprioception
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125378.3 and AC124480.5.
            
            On May 27, 2020 this sequence version replaced XM_011249426.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.5560716.1,
                                           ERR3363660.684149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC125378.3         61486-61548
            64-153              AC124480.5         21421-21510
            154-207             AC124480.5         24005-24058
            208-240             AC124480.5         24150-24182
            241-308             AC124480.5         24283-24350
            309-436             AC124480.5         30863-30990
            437-614             AC124480.5         33366-33543
            615-2804            AC124480.5         37056-39245
FEATURES             Location/Qualifiers
     source          1..2804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.46 cM"
     gene            1..2804
                     /gene="Tmem150c"
                     /note="transmembrane protein 150C"
                     /db_xref="GeneID:231503"
                     /db_xref="MGI:MGI:3041258"
     exon            1..63
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            64..153
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..823
                     /gene="Tmem150c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tentonin 3"
                     /codon_start=1
                     /product="transmembrane protein 150C isoform 1"
                     /protein_id="NP_001369780.1"
                     /db_xref="GeneID:231503"
                     /db_xref="MGI:MGI:3041258"
                     /translation="MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAA
                     RKSGAKHAPYISFAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNIS
                     GLAALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEG
                     RRAGIPRVILSAVITLCVVLYFILMAQDIHMYAARVQWGLVMCFLAYFGTLAVEFRHY
                     RYEIVCSEYQENFLSFSESLSEASEYQTDQV"
     exon            154..207
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            208..240
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            241..308
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            309..436
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            437..614
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     exon            615..2804
                     /gene="Tmem150c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem150c"
                     /note="hexamer: AATAAA"
     polyA_site      2804
                     /gene="Tmem150c"
                     /note="major polyA site"
ORIGIN      
        1 gactgccacc gccgccgctg ccgccgcagg tcacggcccg cgagccgccg ccgcccggag
       61 cagttgcaca ggcatggacg ggaagaaatg cagcgtgtgg atgtttctac ctctcgtgtt
      121 tactttgttt acttcagctg gcttgtggat agtgtacttt atagccgtgg aagatgacaa
      181 aattttgcca ttaaattcag ctgcaaggaa atcgggtgcg aagcatgctc catacatcag
      241 ttttgcaggt gacgaccctc ctgcgagctg tgtgttcagt caagtaatga acatggccgc
      301 cttcctagcc ctcgtggtag ctgttctgcg cttcatccag ctaaaaccaa aggttttaaa
      361 cccatggctg aatatcagcg gtctggcggc gctgtgtctg gcttcctttg gaatgacctt
      421 acttggtaat ttccagctca caaacgatga agaaatccac aacgtgggga catccctgac
      481 cttcgggttt ggcactctga cctgctggat ccaggccgca ctgacactca aagtcaatat
      541 caagaacgag gggcggagag ctgggatccc gagagtcatc ttgtcagctg tcattaccct
      601 ctgcgtagtc ctgtatttca tcctgatggc ccaagatatc cacatgtacg cagccagggt
      661 ccagtggggc ctggtcatgt gcttcctggc gtactttggc accctggctg tggagttccg
      721 gcactaccgc tatgagattg tgtgctccga gtaccaagag aacttcctga gcttctcaga
      781 aagcctgtca gaagcttctg aatatcagac ggatcaggtg tagcaacagt ttgtccttgg
      841 gggtgcggtg ggtgtggcaa caggggaggg gccaggagga tacactcacg ggactcgaca
      901 catcacctca cgatgctttt cacacacaca cacacacacg gatgcacact cacggccata
      961 tctgacagaa gagcttttca gggcaggtta cttctttctt gaacaagcac aagccctcat
     1021 gtatggaaat acacgctgtc acaccgaaaa catgcacgac agagccagaa gcttgtgcat
     1081 gaccacctcc ccgcccccca cgccctccca gcaggccttg cgcttctcat ccttttcccg
     1141 gttccaacct ggcatcttcc tcctgcaaag taaggccggc cgaatgtaaa gtgagagtca
     1201 agccagctcc ctaagtcgcc ttcaggttgg aagggtttga ggcgagcacg aggggaactt
     1261 gagtggaaac ctaggagcat ctggctgcat gcaccccgca ctaaagctgg ccgtggcctg
     1321 agaggcgtgg gcagagcttt cccatcagtc tgacatcatc actgttcagc ggtcggcttt
     1381 gtggatccag agagagaagc atgctacaga gagtgagcgg gaaagaagcc ggccaccagc
     1441 atttggactt gagtcactct gcctgaggaa gatctccaaa cgtgaatgct accggggaca
     1501 gtcagccgcg aatggcacga ggtacggctg agagggcgtg gcttggtttt tccttccaca
     1561 gtgcatcacc cacagttcca gtttgcattt tctttttgaa gtgccactct cacgggtcta
     1621 tgtaggcctc gtgggcaaag gtgtggacca aaggcaagaa ccttgttttg gcttcaagta
     1681 tgaaaggggt atacgtgcaa gcttaattta tatctgaaga aataataaga aaaaaagatt
     1741 ctcgaagaat cgcaaaagaa atctacatgg aggtgaaagg tatgagggct ctgaggaaag
     1801 acaggaggtt agccctcttg ctgctagtcc aacccagggg agattttaac atccgtgtgt
     1861 tgctcaaatt ttatagtttg aggactgggg actttaaatt aaatttggaa gttatagaag
     1921 caaattaaaa acatcgccct cccgcaaatc acattggcac aaatggagct gcaatactgc
     1981 taagctgttc ggagatgagc ccagaggtgc aggagttcaa ggccatccta gatccctgtg
     2041 ccaacaacag agtgccaagt gcacaagcac cccctccccc aaccaagtgc acaagcaccc
     2101 cctccccaac caagtcacaa gcaccccctc cccaaccaag tcacaagcac cccctcccac
     2161 attgtttcaa aaaactctcc aaactcctag ggggctcaga cagcccggaa tgtaatgtgg
     2221 aaaacgttgt tttgtaaatt caccctgaag tatagcttcc caaggaaggg ttcaaatgct
     2281 aaatctccgc cccccagcat agcgccgagc acgagcacac agtaaatgtc caaatgaaca
     2341 gatttgctgc tcgtttctga gtggaggtga ggagcatcaa agagattcag agacaaacga
     2401 cagagtggaa gacagagtga agaaggaggg ggaggactca tcactacagg gcagggcagg
     2461 gcagggagtg aaaagccccc agtggtgtga gaaagcctcg agtagagtat tctcttatta
     2521 aaaaaggcgt cttaccgtaa atactccagg gggatgtctg ttagttttga aactgctatg
     2581 aggtttctct tctttcctcc ttttcacttt tctattttaa agatttttat caaagaacaa
     2641 acggttttat tttactctcc acactccaag taaagagctt tcggtgacac acttctctgc
     2701 gttcttaaga gtgtgcagca gcagcagcgg cagcagcagc atccagccaa tactgacatt
     2761 actcactggg acctggccac tgaataaagg ggttttatgc taaa
//
