LOCUS       NM_029398               1190 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 14A (Tmem14a), transcript
            variant 2, mRNA.
ACCESSION   NM_029398
VERSION     NM_029398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163025.3 and BC060034.1.
            
            On Mar 19, 2014 this sequence version replaced NM_029398.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1. The encoded protein
            (isoform 2) has a shorter and distinct C-teriminus, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060034.1, BU847965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC163025.3         120473-120528
            57-1190             BC060034.1         1-1134
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.5 cM"
     gene            1..1190
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /note="transmembrane protein 14A"
                     /db_xref="GeneID:75712"
                     /db_xref="MGI:MGI:1922962"
     exon            1..315
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            316..401
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..631
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 14A isoform 2"
                     /protein_id="NP_083674.2"
                     /db_xref="CCDS:CCDS35523.1"
                     /db_xref="GeneID:75712"
                     /db_xref="MGI:MGI:1922962"
                     /translation="MDLIGFGYAALVTIGSVLGYKRRGGVPSLIAGLSVGLLAGYGAY
                     RVSNDRRDVKVSLFTAFFLATIMGVRFKRSKKVMPAGLVAGLSLMMILRLVLLLL"
     exon            402..503
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            504..591
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1168
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="Tmem14a"
                     /gene_synonym="5730496E24Rik; PTD011"
                     /note="major polyA site"
ORIGIN      
        1 gggggaagca gactccaacc ctgcgctctc ggggcctaca cagccgggtg gggaagcgac
       61 ttcacttccc agggtcttgg cctctgctgg cccagagctg caccccactc ccaggccgag
      121 gacagtagaa gaacttggga tccaggactc tacaacgcac gaaccagctc cagagaggac
      181 tcagctctgt gcactctgct ctctaaggcg ggtcgcagct aggcagtgcg cctgcgcaga
      241 actgcttccg gattgaggga ctactcttgc gctttttccg ctttcaccag ctgcagcaag
      301 tgctcaaggg tgcagacttg catccttacc aatggacctg attggttttg gttatgcagc
      361 ccttgtgaca attgggagtg ttttgggata taagcgaaga ggtggagttc catctctgat
      421 tgctgggctt tctgttggac ttttggctgg ctacggagcc taccgtgtct ccaatgacag
      481 acgggatgtc aaagtgtcat tgtttacagc tttcttcctg gccaccataa tgggtgtgag
      541 atttaagagg tccaagaaag taatgcctgc tggtctagtt gcaggcttaa gcctcatgat
      601 gatcctgaga cttgtgctgc tgctgctgta gcgtctggac aagctgagag ccaaatgccc
      661 agcatgctaa gtgcctggca cggcaggttc ctgcattgaa gtggtcattt taaatacatg
      721 ggaaatgtct tatattgaaa tgaaaataat gtcactataa tatttaaaaa tcattggcaa
      781 tgtttattta cccccaatgc ctttttattt aatgcacaaa tttatttaga tgtttctgtt
      841 tgctaatcct gctctttaat gcattgttac tgctcattcc ctttgtctct ttatatctgg
      901 aaattgggga cttgcaattt tctgcttttg acaattccaa acactatgag tgaaataagt
      961 taaataagtt aactgcatcc tgtcagacaa tgggattcct gtcgtgggcc acagggagtg
     1021 ttaatgaatt ataagtcact ttgtacttag gggttttatt tgtattattg ggggtggggc
     1081 aggtttgcat agaaggaatt ctattctcag cacatcagca tcctgacaca atgcactcag
     1141 tgttgaaata aaatgcatct tagtctaaaa aaaaaaaaaa aaaaaaaaaa
//
