LOCUS       NM_001379543            2745 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 144 (Tmem144), transcript
            variant 3, mRNA.
ACCESSION   NM_001379543 XM_006502057
VERSION     NM_001379543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159281.3.
            
            On Apr 9, 2020 this sequence version replaced XM_006502057.4.
            
            Transcript Variant: This variant (3), as well as variants 1 and 2,
            encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3642078.1,
                                           ERR2844019.1173646.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC159281.3         198914-199052       c
            140-308             AC159281.3         195281-195449       c
            309-431             AC159281.3         192377-192499       c
            432-531             AC159281.3         190051-190150       c
            532-612             AC159281.3         188205-188285       c
            613-694             AC159281.3         183758-183839       c
            695-771             AC159281.3         182966-183042       c
            772-890             AC159281.3         181422-181540       c
            891-1010            AC159281.3         178774-178893       c
            1011-1108           AC159281.3         177401-177498       c
            1109-1162           AC159281.3         173160-173213       c
            1163-2745           AC159281.3         168707-170289       c
FEATURES             Location/Qualifiers
     source          1..2745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.07 cM"
     gene            1..2745
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /note="transmembrane protein 144"
                     /db_xref="GeneID:70652"
                     /db_xref="MGI:MGI:1917902"
     exon            1..139
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            140..308
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1246
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /note="isoform a is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transmembrane protein 144 isoform a"
                     /protein_id="NP_001366472.1"
                     /db_xref="GeneID:70652"
                     /db_xref="MGI:MGI:1917902"
                     /translation="MSSNATDLTTGYLSSAAAILLFGSNFVPLKKYDTGDGMFLQWVL
                     CAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKTIGLGLGILIWGSFN
                     TLTGWASSRFGWFGMDAEEVSKPMLNYVGAGLSVVSALTFLFIKSEIPNNPGSSDTTP
                     LMTEPVINRTEDRSADSSWVDRLSTTYHRIVGCSLAVISGILYGSTFVPIIYIKDHSR
                     RNDSMYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGV
                     LWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLMMLAFC
                     IILAGALCTAFSKV"
     exon            309..431
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..531
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..612
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            613..694
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            695..771
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..890
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1010
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1108
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1162
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2745
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2745
                     /gene="Tmem144"
                     /gene_synonym="1110057I03Rik; 5730537D05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agattccggc aggaagtccg cacgcgtcca gggaagagtc agcgcagtga gaccccacca
       61 ggtcacctga gtctaaggtg cccctgggtc tgagagccgc cctgcaacct tcagctcctc
      121 gggaaaactc gcagagcaaa atctcctgta aaaacacaga tcgaaagtaa gacgggctgc
      181 tgtctgctac cctgcaacca tgagcagcaa tgcaacagac ctcaccaccg gctacctctc
      241 ctctgctgcg gcaatcctcc tgtttggctc caactttgta ccacttaaaa aatatgacac
      301 tggcgatggg atgttccttc agtgggtgct ctgtgctgcc atttggttgg ttgccttggt
      361 ggtcaacttg atactgcact gccctaaatt ctggccgttt gcgatgcttg gcggctgcat
      421 ttgggcaaca ggcaacattg ctgtcgttcc aattatcaaa accatcggtt taggacttgg
      481 aatcctaatc tggggatcat ttaacacctt aactggctgg gcaagctcaa ggtttggctg
      541 gtttgggatg gatgcagaag aagtgtccaa gccaatgctg aattacgttg gagctgggct
      601 gtcagtagta agtgcgctca cgtttttgtt catcaaaagt gaaattccga ataacccagg
      661 cagctcggac accacaccac tgatgacaga gcctgtgatc aacagaaccg aggaccggag
      721 tgcggattcc tcctgggtgg atagactttc taccacgtac caccgcattg tgggctgcag
      781 ccttgcggta atatctggaa tactctacgg atcgacattt gtgccaatca tttacatcaa
      841 ggatcacagc agaagaaatg acagcatgta cgcaggcgct agccagtatg atttagacta
      901 cgtgttcgca cactccagtg gcatctttct tacaagtaca gtctactttg tggcctactg
      961 tgtagccatg aaaaataggc caaagctgta tccagaggca gtcttaccag gcttgctgtc
     1021 aggggtgctg tgggccatcg ccacctgctg ctggttcatc gccaaccact cactaagcgc
     1081 cgtgatcagc ttcccgatca tcactgctgg tcctggactt attgctgcac tttgggggat
     1141 actcattttc aaggaaatac agggtctccg aaactactta ctgatgatgc tcgctttctg
     1201 catcatctta gctggggcct tgtgcaccgc tttttctaaa gtgtagctgt tcacggcaag
     1261 agcagcagag ggcagcagag ggcagcagcg gctaggagaa ggacctctgc tgcgcaagct
     1321 aacactacag gcagctaagc tgtggcactg tgggtctctg ccactctggg aatgaacgga
     1381 taaatggctg ttggctccac caacgtgaga acgcgaagag agaccgtgtt tcagttcagc
     1441 gtgtgtgaaa actcttttcg atgagctatt aacgaaggct ggacctcgct gggtggctca
     1501 aaggcatatc ggatcatcct gtctaacaat gtctacttaa tactataatc cagaaaatag
     1561 gatggagttt gtacaaaaga aattaccatc ccaatttata atttattaat aaagaggacc
     1621 caaaataagt actttcttgg ttgtgggaag gaacacacac ataccttgtg gaatttacat
     1681 tcaaagatat cggccccttt gctaagagca aatgtcatag ttgcaacctg aatgtttaaa
     1741 atgccatttc tttttttttt tggccaaaaa ttattacttt aatactactc cgctctttat
     1801 cttgcctgac cttcttagct caaaatgttt gataattatt ccagataaaa cggatcctca
     1861 gagagcaggt caccaccact cctatgtacg tgtgatataa tgtatacatt cacaagcaca
     1921 catacgtgtg tgcatggttt cagatttgga cacattctag agttgctgaa atagcagttt
     1981 tagttcatca cgttcaactt aaaggaagcc gacttgtttg actgcacaac taattttttc
     2041 ctccttaaac acagttactt aaaagatcat tttaactgga agtgtttctt ttgaccctat
     2101 tttaactgat ttccaggaga caaaagaagg tagcatatat attgatttga ttctttaagg
     2161 gaaaaaaaaa aaaacacagg cacattgctc acaatcatgc tctctgcacc cttaatagaa
     2221 taatggtgtt tggctgtgcc tttcacccat tctctcctga tattgcagta ctttgttgtg
     2281 ccagagcaac agaatagcat cctgcacctg cctcggctta aacctcagat gctccgtctg
     2341 agttgtgcag ctttggacct gagagctctc tcggcatggc aggcttcctg ggaaggaggg
     2401 ctagcgatag catgtgcctt gaattctgtt gtccaaatgt ctccttgcct gacaaacact
     2461 ctaaacttct ttgctattgt tactacatgt taatcaaggg gaaacaacgt ttacaggtag
     2521 gaaaaactta caacttataa aaactactgg acttaccacc ctcagcccaa ttgaactttg
     2581 tcttgccaaa tcagaaacat ccctggagtc ccttctaatc attgaattgc tcacacaaat
     2641 aatgtttgat attaacaatg tcttttttct atttcagttt ttacttgaaa tgtcattaaa
     2701 ttgtgatggt atggcaattt ctgaataaac atgacagaaa aacta
//
