LOCUS       NM_144801               2184 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus transmembrane protein 143 (Tmem143), mRNA.
ACCESSION   NM_144801
VERSION     NM_144801.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB666121.1, AK039173.1, AK087636.1, BB739600.1 and BE946904.1.
            
            On Nov 15, 2007 this sequence version replaced NM_144801.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017618.1, SRR7345562.253033.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               BB666121.1         1-571
            572-924             AK039173.1         642-994
            925-1804            AK087636.1         1130-2009
            1805-2167           BB739600.1         18-380
            2168-2184           BE946904.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.58 cM"
     gene            1..2184
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /note="transmembrane protein 143"
                     /db_xref="GeneID:70209"
                     /db_xref="MGI:MGI:1917459"
     exon            1..33
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1387
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /codon_start=1
                     /product="transmembrane protein 143"
                     /protein_id="NP_659050.2"
                     /db_xref="CCDS:CCDS21269.1"
                     /db_xref="GeneID:70209"
                     /db_xref="MGI:MGI:1917459"
                     /translation="MTVARWLRLWERGQAMLHVTWGSKVRLWSLVPALLGTPRALSSL
                     ENRMGVYRKMWNPKEPCDWAQQYRERFIPFSKEQLLRLLIQEFHSSPAERAALEAFSA
                     HVDFCTLFHYHQLLARLQALYDPINPDRETLDQPSLTDPERLSSEKDVLQALRPLLAQ
                     ANFSPLSEDALAYALVVHHPQDEVQVTINLDQYIYIQFWALGQRVGQMPHKSSVGSKR
                     GFFRKLPPVERRYFKRVVLAARTKGGHLVLKSFKDTPLEGLEQLLPELKVRTPVLQRA
                     LLNLMLVVSGVMIFVNVGMVILSDLKMATSLLLLLFAAFMGVKASKVFGQRRSAQALE
                     LAHVLYYRSTSNNSELLSALALRAQEEHIKEALLAHSFLARRPGGSQGKPEETSRWLQ
                     SEVESWLLAQSGCDVTFNGPRALAHLQALTPSLGLFPPPELPQLDPMVLGTPEATQAA
                     LGSSYPSP"
     exon            34..265
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            266..370
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..565
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            566..696
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..976
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1166
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2169
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2169
                     /gene="Tmem143"
                     /gene_synonym="2310076O21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaaggctca atgacagtcg cgcgttggtt aaggctctgg gaaagggggc aggccatgtt
       61 gcatgtgacc tgggggtcca aggtccgact atggtccctg gtgcctgctc tcctcgggac
      121 tccccgagct ctgtcgtccc tggagaacag gatgggggtg taccgcaaga tgtggaaccc
      181 caaggagccc tgcgactggg cccagcagta ccgcgagcgc ttcattccat tctccaagga
      241 gcagctgctc cgcctcctga tacaggagtt ccactccagc ccagcggaga gagcagcttt
      301 ggaggcattc tcagctcacg tggacttctg taccctcttt cactaccatc agctcctggc
      361 caggctgcag gccttgtatg accccatcaa ccccgacagg gagaccctgg accagccgtc
      421 ccttactgac cccgagcgcc tgtccagtga gaaggatgtg ctccaggctc tgaggcccct
      481 gctggcccag gccaacttct ctccactctc tgaagatgcc ctggcttatg cactagtcgt
      541 ccatcatcct caggatgagg tccaggtgac aataaatttg gatcagtata tctacataca
      601 gttctgggcc ctgggccaga gagttgggca gatgccccac aagtccagtg tgggctccaa
      661 gcgtggcttc ttcagaaagt tgccccctgt ggagaggaga tacttcaagc gtgtggtgtt
      721 ggctgcccgg acgaaaggag ggcacctggt cctgaagagc ttcaaggata ccccgctgga
      781 gggcttagag cagctgctgc cggagctgaa ggtgcgcacg cccgtgctgc agcgcgccct
      841 gctcaacctc atgttggtgg tctcaggcgt catgatcttc gtcaacgtgg gcatggtgat
      901 actgtctgac ctcaagatgg ccacctccct gctgctgctg ctctttgctg ccttcatggg
      961 cgtgaaggcc tccaaggtgt ttgggcagcg ccgcagtgcc caggcgctgg agctggcaca
     1021 cgtgctgtac taccgaagca cgtccaacaa ctcagaactg ctcagtgccc tggcactccg
     1081 agcccaggag gaacatatca aggaagccct cctggctcac agcttcctag cccgccggcc
     1141 agggggctcc caaggcaaac ctgaagagac ctccaggtgg ctgcagtctg aagtggaaag
     1201 ctggcttctg gcccaatcag gctgtgatgt aaccttcaat ggacctcggg ccctggccca
     1261 tctgcaagcc ctgaccccca gccttggact gttcccacca cctgaattgc cacaactgga
     1321 cccaatggtc ctaggcactc cagaggccac gcaggctgcg ctgggtagca gctacccctc
     1381 accctgacca cttactacca ggccctgcgc tgacagggtc ccaagctccg cctcctccgt
     1441 ggcaaactgt cagttgtggc aactgcatct ccttcctgga ctttcagttg ttgacaggct
     1501 attatttctg ctaggccatt aattttgcta tgctatagac gtaagagtag ccaatcgggg
     1561 ctgctggcag ttgctaggca gcctcctgag gccaaccaat caaagccgtt tatttcaact
     1621 tgttatttta tttcttagac ccgcctctgg cgggaacctc accaaggtcg ctggaggagg
     1681 cgggacttgg ggaggctcac acagctgctg gattgcagct gccagccttg gccacattga
     1741 gatgggccag gctgtgaaag ctgcatgggg gcggggagga gggacggggg tgggagtggg
     1801 ggaagctgct ttattttcta tttaacctgc gcagaactgc tcgccacagg cacctgagcc
     1861 atttgcccct ggcacacagt gggtgacaga cactgggcac ctcagccaca ggcagccggt
     1921 cagaatgtct ggaggaacct cttcagaccc cacgtaagat gagccatctg ttctgcagct
     1981 catctgctct ggttggaggc actggaaact tcatgcccca aagaagaatt gcaggattcc
     2041 accccaagat cactccagcc caggccccag caggctccgt ggcccgctct gcctcgctgc
     2101 agcaatcccc ttagtctggg tctccctgtc tgtgcaccct cttccaaagg aataaatcat
     2161 gcttaataaa aaaaaaaaaa aaaa
//
