LOCUS       NM_028343               3392 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transmembrane protein 135 (Tmem135), transcript
            variant 1, mRNA.
ACCESSION   NM_028343
VERSION     NM_028343.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3392)
  AUTHORS   Liu,J., Bao,X., Huang,J., Chen,R., Tan,Y., Zhang,Z., Xiao,B.,
            Kong,F., Gu,C., Du,J., Wang,H., Qi,J., Tan,J., Ma,D., Shi,C. and
            Xu,G.
  TITLE     TMEM135 maintains the equilibrium of osteogenesis and adipogenesis
            by regulating mitochondrial dynamics
  JOURNAL   Metabolism 152, 155767 (2024)
   PUBMED   38154611
  REMARK    GeneRIF: TMEM135 maintains the equilibrium of osteogenesis and
            adipogenesis by regulating mitochondrial dynamics.
REFERENCE   2  (bases 1 to 3392)
  AUTHORS   Hu,D., Tan,M., Lu,D., Kleiboeker,B., Liu,X., Park,H., Kravitz,A.V.,
            Shoghi,K.I., Tseng,Y.H., Razani,B., Ikeda,A. and Lodhi,I.J.
  TITLE     TMEM135 links peroxisomes to the regulation of brown fat
            mitochondrial fission and energy homeostasis
  JOURNAL   Nat Commun 14 (1), 6099 (2023)
   PUBMED   37773161
  REMARK    GeneRIF: TMEM135 links peroxisomes to the regulation of brown fat
            mitochondrial fission and energy homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3392)
  AUTHORS   Landowski,M., Bhute,V.J., Grindel,S., Haugstad,Z., Gyening,Y.K.,
            Tytanic,M., Brush,R.S., Moyer,L.J., Nelson,D.W., Davis,C.R.,
            Yen,C.E., Ikeda,S., Agbaga,M.P. and Ikeda,A.
  TITLE     Transmembrane protein 135 regulates lipid homeostasis through its
            role in peroxisomal DHA metabolism
  JOURNAL   Commun Biol 6 (1), 8 (2023)
   PUBMED   36599953
  REMARK    GeneRIF: Transmembrane protein 135 regulates lipid homeostasis
            through its role in peroxisomal DHA metabolism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3392)
  AUTHORS   Landowski,M., Bhute,V.J., Takimoto,T., Grindel,S., Shahi,P.K.,
            Pattnaik,B.R., Ikeda,S. and Ikeda,A.
  TITLE     A mutation in transmembrane protein 135 impairs lipid metabolism in
            mouse eyecups
  JOURNAL   Sci Rep 12 (1), 756 (2022)
   PUBMED   35031662
  REMARK    GeneRIF: A mutation in transmembrane protein 135 impairs lipid
            metabolism in mouse eyecups.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3392)
  AUTHORS   Lee,W.H., Bhute,V.J., Higuchi,H., Ikeda,S., Palecek,S.P. and
            Ikeda,A.
  TITLE     Metabolic alterations caused by the mutation and overexpression of
            the Tmem135 gene
  JOURNAL   Exp Biol Med (Maywood) 245 (17), 1571-1583 (2020)
   PUBMED   32515224
  REMARK    GeneRIF: Metabolic alterations caused by the mutation and
            overexpression of the Tmem135 gene.
REFERENCE   6  (bases 1 to 3392)
  AUTHORS   Landowski,M., Grindel,S., Shahi,P.K., Johnson,A., Western,D.,
            Race,A., Shi,F., Benson,J., Gao,M., Santoirre,E., Lee,W.H.,
            Ikeda,S., Pattnaik,B.R. and Ikeda,A.
  TITLE     Modulation of Tmem135 Leads to Retinal Pigmented Epithelium
            Pathologies in Mice
  JOURNAL   Invest Ophthalmol Vis Sci 61 (12), 16 (2020)
   PUBMED   33064130
  REMARK    GeneRIF: Modulation of Tmem135 Leads to Retinal Pigmented
            Epithelium Pathologies in Mice.
REFERENCE   7  (bases 1 to 3392)
  AUTHORS   Lee,W.H., Higuchi,H., Ikeda,S., Macke,E.L., Takimoto,T.,
            Pattnaik,B.R., Liu,C., Chu,L.F., Siepka,S.M., Krentz,K.J.,
            Rubinstein,C.D., Kalejta,R.F., Thomson,J.A., Mullins,R.F.,
            Takahashi,J.S., Pinto,L.H. and Ikeda,A.
  TITLE     Mouse Tmem135 mutation reveals a mechanism involving mitochondrial
            dynamics that leads to age-dependent retinal pathologies
  JOURNAL   Elife 5, e19264 (2016)
   PUBMED   27863209
  REMARK    GeneRIF: The authors observed localization of TMEM135 on
            mitochondria, and imbalance of mitochondrial fission and fusion in
            mutant Tmem135 as well as Tmem135 overexpressing cells, indicating
            that TMEM135 is involved in the regulation of mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3392)
  AUTHORS   Exil,V.J., Silva Avila,D., Benedetto,A., Exil,E.A., Adams,M.R.,
            Au,C. and Aschner,M.
  TITLE     Stressed-induced TMEM135 protein is part of a conserved genetic
            network involved in fat storage and longevity regulation in
            Caenorhabditis elegans
  JOURNAL   PLoS One 5 (12), e14228 (2010)
   PUBMED   21151927
  REMARK    GeneRIF: TMEM135 integrates biological processes involving fat
            metabolism and energy expenditure in both the worm (invertebrates)
            and in mammalian organisms
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3392)
  AUTHORS   Wiese,S., Gronemeyer,T., Ofman,R., Kunze,M., Grou,C.P.,
            Almeida,J.A., Eisenacher,M., Stephan,C., Hayen,H.,
            Schollenberger,L., Korosec,T., Waterham,H.R., Schliebs,W.,
            Erdmann,R., Berger,J., Meyer,H.E., Just,W., Azevedo,J.E.,
            Wanders,R.J. and Warscheid,B.
  TITLE     Proteomics characterization of mouse kidney peroxisomes by tandem
            mass spectrometry and protein correlation profiling
  JOURNAL   Mol Cell Proteomics 6 (12), 2045-2057 (2007)
   PUBMED   17768142
REFERENCE   10 (bases 1 to 3392)
  AUTHORS   Pinto,L.H., Vitaterna,M.H., Siepka,S.M., Shimomura,K., Lumayag,S.,
            Baker,M., Fenner,D., Mullins,R.F., Sheffield,V.C., Stone,E.M.,
            Heffron,E. and Takahashi,J.S.
  TITLE     Results from screening over 9000 mutation-bearing mice for defects
            in the electroretinogram and appearance of the fundus
  JOURNAL   Vision Res 44 (28), 3335-3345 (2004)
   PUBMED   15536001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122386.3, AK013269.1 and AC116659.3.
            
            On Feb 10, 2018 this sequence version replaced NM_028343.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013269.1, AK028401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC122386.3         104938-104964       c
            28-3209             AK013269.1         2-3183
            3210-3392           AC116659.3         135802-135984       c
FEATURES             Location/Qualifiers
     source          1..3392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.32 cM"
     gene            1..3392
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="transmembrane protein 135"
                     /db_xref="GeneID:72759"
                     /db_xref="MGI:MGI:1920009"
     exon            1..340
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1576
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="isoform a is encoded by transcript variant 1;
                     peroxisomal membrane protein 52"
                     /codon_start=1
                     /product="transmembrane protein 135 isoform a"
                     /protein_id="NP_082619.3"
                     /db_xref="CCDS:CCDS21440.1"
                     /db_xref="GeneID:72759"
                     /db_xref="MGI:MGI:1920009"
                     /translation="MAALSKSIPHNCYEIGHTWHPSCRVSFLQITWGALEESLRIYAP
                     LYLIAAVLRKRKLEYYLYKLLPEILQSASFLTANGALYITFFCILRKILGKFYSWTPG
                     FGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCI
                     TAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSYSPETAYAKVEQKREKHKGTPR
                     AMSIIALVRTLVDSVCKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPS
                     AFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAG
                     FLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPQADTIIYSISTAICFHA
                     AVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFIPRLDPRYTVVT
                     PELPIDFS"
     exon            341..468
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            469..561
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            562..595
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            596..661
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            662..708
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            709..750
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            751..897
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            898..967
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1135
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1199
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1276
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1375
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1443
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..3392
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="hexamer: ATTAAA"
     polyA_site      2892
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="major polyA site"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="hexamer: ATTAAA"
     polyA_site      3219
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
                     /note="hexamer: AGTAAA"
     polyA_site      3387
                     /gene="Tmem135"
                     /gene_synonym="2810439K08Rik; PMP52"
ORIGIN      
        1 gtgcgcgccc cgccccctcg cgctgccata cgcggacggc caacatccga ggactccggc
       61 cttgagtaac ctgctcccgt gaccttttcg caccccgcac gccgaggccc gcgcggcgcc
      121 cgcctcgccc ttgcgtgtct gccgcccctg ccgaaccctg cgttcccctg accacgcgca
      181 gctgccaccg ccactcgtca tggcggccct cagcaagtcc atccctcata actgctacga
      241 gatcggccac acttggcacc cctcctgcag ggtctccttc ctgcagatca cttggggcgc
      301 cctggaggag tccctcagga tctacgcacc cctgtacctg attgcagctg ttctccggaa
      361 gcgcaagctg gagtattacc tgtacaaact gcttcctgag atcctccagt ccgcctcctt
      421 cctgactgct aatggggcct tgtacattac tttcttctgc attttaagga agatccttgg
      481 aaaattctac tcatggactc ctggctttgg tgctgctctg ccagcctcat atgtggccat
      541 tctaattgaa agaaaaagca ggagagggct gctcacaatt tatatggcca acttggccac
      601 agaaacacta tttagaatgg gtgttgcaag aggaaccatc acgacgttaa gaaatggaga
      661 agtccttttg ttctgcatca cagcggccat gtacatgttc tttttcaggt gcaaagatgg
      721 cttaaaaggc tttacatttt ctgcacttag gtttatcgtg gggaaggaag aaattcccac
      781 gcactcttac tcaccagaga cagcgtatgc caaagtggaa cagaagaggg agaagcacaa
      841 gggaacgccg agagcaatga gcataatcgc tctggttcgg actctcgtgg actccgtatg
      901 caagcatgga ccaaggcaca gatgctgcaa gcattatgaa gacaactgca tttcctactg
      961 cattaaaggc ttcatcagaa tgttcagcgt gggctacttg atccagtgct gtctccggat
     1021 cccctctgcg tttaggcatc tgtttacaga accatcccgg ctcctctctc ttttctacaa
     1081 caaggagaac ttccagctgg gggctttcct tggatctttt gttagtatat acaagggcac
     1141 aagttgtttc ctgcgctgga tcaggaatct ggatgacgag ctgcatgcta ttgtggctgg
     1201 gtttttggca ggtgtgtcga tgatgtttta taaaagcaca acaatttcca tgtacctagc
     1261 ttccaagctg gtggagacaa tgtatttcaa gggcatcgag gctggaaagg ttccctattt
     1321 tcctcaagca gatacgatca tctattccat ctctacagca atttgtttcc acgcagctgt
     1381 tatggaagtt cagaacttgc gaccatctta ctggaagttc cttttaaggc tcaccaaggg
     1441 caggtttgca ctcatgaacc gaaaagccct ggatgtgttt ggtactggcg catctagaga
     1501 gtttcacaac ttcatcccca gactagaccc acggtacaca gttgtcacac cggagctgcc
     1561 catagacttt tcctgaagat gactgtaact tattgactgt gtctcaccat tttctcctga
     1621 agagttaatt atgttcaaca cagaaggggc ccaagctgaa cctcagtgtt acgtcaacga
     1681 gagatgcttt ttctttcttt tcataccaat cagaaataca gaagcttttt agaaaggcgt
     1741 tgcttaataa ttaagcttcc tctgtagcca gaatctcatt ctggatcatg tagtgttgac
     1801 attatgatat attgttgatt aaattatgtc cacaaagaat attgaataat ctatgtagaa
     1861 atataataag aagagtatac ttaaaaatta ctttaaaaga tatctttagt tcattccaat
     1921 agaattcttg gtcaaaacta agaatatttc ttcactttag gatttgcaaa ggatctcggg
     1981 tacatggatt cagcccgtga tctttacgct tttgaatgga tttctgtagc tgtggggcgt
     2041 tggagatggg gcattgctgc tttgctgtgg agcaatgtgg agaaagtggc cattcttatt
     2101 tcagggatac aaacgtgggt ttcataccat ttgagccagt gtcatggtgg tacccatact
     2161 cttttgttca gctctcagtc ctgtctctct tcgagaccag atgggctggt tggcagccta
     2221 gtgaccttat atgataatag caggttagga acaaatggaa accgacaggt gctgctgtaa
     2281 aaaatgtctc agtgttcaca ggagtgttac acttgaatat tgtcaagcag acaacctaaa
     2341 agccaatctt cacacctcct ataggcagat tgtgtttatt ttcaccacag tggctgtgct
     2401 ctttatagct cagtttcaat gtcattggtg ttttagaaag ggttaagatc ctatggaaca
     2461 aaagagcttt gggccagttt gacagttggt accccctcta atgcctcacc taaatggggc
     2521 gttttatgac gaaaaatgtg aaaatgcagt gattgttggg agttcctctc tcactaattg
     2581 gcttcctgtt cattaaccag ttctggctgg agttaaggga caccagatgg ttggtgctga
     2641 ttatagaagc agtcctggac agctgactga gatatgatca cttggctttt ctggggaaag
     2701 ttgtactttt ctaagttaat atagaagtct aaagtggctg tgatgtctac agttaatgta
     2761 atatatagga attatcttta aatatataat tttgttgcta aaaatgtttc aggccattgt
     2821 aagttatgca gtagaacttg tgttatgaca ggaattgtaa ctcaagacat taaaaatact
     2881 taacctccct tattcagttg catcagcact tgtatttctg tgtaacccta cccttggttg
     2941 ttatagaaaa ttgagtccct acaaagagac agactctagt gccatcatgt aacagaacca
     3001 cttgagtttg ctcagaattt tgcgttacga ttagcgttct agagtggact tacctgcttg
     3061 gtaacacatt gaagggtcat tttgggtttg gacttccaca ctgattaatt aattaatgca
     3121 gttttaggtt tttattcact ggaatcggac tgatgattag tactgtgttt ccctttgaaa
     3181 atgaagtatt aaagcactga gaacgcctgg ctacctggac ctcattttct cctctcaggt
     3241 tttatgtctg ttgtgttttt cttgtcaggt taaaaaatct attttacgcc ataagtcatt
     3301 cttttcattg ccatcaaaag actgtgataa tgattaatcc tatcggaatg tgctaaaaat
     3361 gtttagtaaa atcttgctgg tcaaaaaggt gc
//
