LOCUS       NM_133804               3543 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus transmembrane protein 132A (Tmem132a), transcript
            variant 1, mRNA.
ACCESSION   NM_133804
VERSION     NM_133804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Zeng,H. and Liu,A.
  TITLE     TMEM132A regulates mouse hindgut morphogenesis and caudal
            development
  JOURNAL   Development 150 (14) (2023)
   PUBMED   37390294
  REMARK    GeneRIF: TMEM132A regulates mouse hindgut morphogenesis and caudal
            development.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Li,B., Brusman,L., Dahlka,J. and Niswander,L.A.
  TITLE     TMEM132A ensures mouse caudal neural tube closure and regulates
            integrin-based mesodermal migration
  JOURNAL   Development 149 (17) (2022)
   PUBMED   35950911
  REMARK    GeneRIF: TMEM132A ensures mouse caudal neural tube closure and
            regulates integrin-based mesodermal migration.
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Wang,Y., Herzig,G., Molano,C. and Liu,A.
  TITLE     Differential expression of the Tmem132 family genes in the
            developing mouse nervous system
  JOURNAL   Gene Expr Patterns 45, 119257 (2022)
   PUBMED   35690356
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Oh-Hashi,K., Sone,A., Hikiji,T., Hirata,Y., Vitiello,M., Fedele,M.,
            Ishigaki,S., Sobue,G. and Kiuchi,K.
  TITLE     Transcriptional and post-transcriptional regulation of
            transmembrane protein 132A
  JOURNAL   Mol Cell Biochem 405 (1-2), 291-299 (2015)
   PUBMED   25926156
  REMARK    GeneRIF: Markedly attenuated the levels of TMEM132A mRNA.
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Oh-hashi,K., Koga,H., Nagase,T., Hirata,Y. and Kiuchi,K.
  TITLE     Characterization of the expression and cell-surface localization of
            transmembrane protein 132A
  JOURNAL   Mol Cell Biochem 370 (1-2), 23-33 (2012)
   PUBMED   22821197
  REMARK    GeneRIF: The novel cell-surface localized glycoprotein, TMEM132A,
            is regulated by several factors, including GRP78, Sar1, and
            intracellular calcium, in a post-transcriptional manner.
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048556.1, AK173207.1 and CF729397.1.
            
            On Feb 18, 2006 this sequence version replaced NM_133804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032956.1, AK048556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK048556.1         2-13
            13-3485             AK173207.1         1-3473
            3486-3543           CF729397.1         226-283
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.26 cM"
     gene            1..3543
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /note="transmembrane protein 132A"
                     /db_xref="GeneID:98170"
                     /db_xref="MGI:MGI:2147810"
     exon            1..241
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3210
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heat shock 70kDa protein 5 binding protein 1;
                     HSPA5-binding protein 1; heat shock protein 5 binding
                     protein 1"
                     /codon_start=1
                     /product="transmembrane protein 132A isoform 1 precursor"
                     /protein_id="NP_598565.2"
                     /db_xref="CCDS:CCDS29589.1"
                     /db_xref="GeneID:98170"
                     /db_xref="MGI:MGI:2147810"
                     /translation="MTERKAAAPRGPYGAWFCLLVALALEVVRVSSNHDTLDPIYLPV
                     ALELLDAPEHFRVQQVGHYPPANSSLASRSETFLLMQPWPRAQPLLRASYPPFATQQV
                     VPPRVTEPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLPCARLHA
                     THPAGTAHRACRFQPSLGACVVELQFPSHWFSQSATTRAELAYTLEPAGEGPGGCGLG
                     TEEEPREQALPVGGVELHPEDPPQYQEVPLDEAVTLRAPDVPMRPGQLFTATLLLRHN
                     FTASLLTLRIKVKKGLQVIAARPAQPTLWTAKLDRFKGSKHHTSLITCHRAGPAGPDS
                     SPLELSEFLWVDFAVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDI
                     RALIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVS
                     EACDAVFVAGQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGW
                     RVPGSAEGQLEPETAAEEVERRSRGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGP
                     DWLLDVSHLVAAHAHVQDPRIASLEGGRILVGREPGVTSIEVRSPLSDAILGEQALAV
                     TDDKVSVLDLRVQPVMGISLSLSRGMSHPGEVTATCWAQSALPAPKQEVALSLWLSFS
                     DHTLAPAELYDRNDLGLSVSAEEPSAVLPAEEQGAQLGVVVSGVGAEGLPLHVALHPP
                     EPCRRGRHRVPLASGTAWLGLPPLPTPVPALPSSPVRTSPFTEATVEGKRQIAGDMGG
                     HVGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAIL
                     IFLVNGVVFVLRYQRKEPPDSATDPASPQPHNWVWLGTNQEELSRQLDRCSSSGPPKG
                     EGGCPCESGAGGDASTVAPSASESPAGSSSTLARKEAGGRRKRVEFVTFAPAPPTQPP
                     EEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS"
     exon            242..456
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..675
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1007
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1157
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1353
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1497
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1700
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1974
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2166
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..3489
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /note="hexamer: AATAAA"
     polyA_site      3485
                     /gene="Tmem132a"
                     /gene_synonym="6720481D13Rik; Hspa5bp1; Orai1"
                     /note="major polyA site"
ORIGIN      
        1 attgtctggg aactgcagcc gcgggccggc ggcgcaggga actagctggc cacagcggct
       61 ggcgcggagc gggcgcggga gatgtgggga cagattgcag ccacctgagc cgcgcgccgg
      121 ttaccctcct ttggtgggaa ggagtgcgcc tcgatgactg aacgcaaggc tgcggcccct
      181 cgggggccct acggtgcctg gttctgcctc ctggtggctc tcgccctgga agtcgtgaga
      241 gttagcagta accatgatac cctggacccc atctacctgc cagtggccct ggaactccta
      301 gatgcccctg agcattttcg tgtgcagcag gtgggccatt acccacctgc caactcttcc
      361 ctggcctccc gctctgagac tttcctgctc atgcagccct ggcccagggc acagccgctt
      421 ctccgggcct cctacccacc ctttgccact cagcaggtgg tccctcctag ggtcaccgag
      481 ccccaccggc ggcctgtccc ttgggatgtg cgggctgttt ccgtggaagc agcggtgact
      541 ccagcagaac cctatgcccg tgtcctcttc cacctcaaag ggcaggattg gccaccagga
      601 cctggcagct tgccctgtgc ccgactacat gccacacacc ctgcaggcac tgcccaccga
      661 gcctgccgct tccagccatc tctgggtgcc tgtgtggtgg aactgcaatt cccctctcac
      721 tggttctccc aaagtgccac cacaagggcc gaactggcct acacgctgga gcctgcaggc
      781 gagggccctg ggggctgtgg ccttggcaca gaggaggaac ccagggagca ggctctccca
      841 gtgggtggtg tggagctgca ccctgaggac cccccacagt accaggaggt acctctggat
      901 gaagcagtca ctttgcgtgc acctgatgtg ccaatgaggc ctggccagct cttcactgcc
      961 acccttctgc ttcgacacaa cttcactgcg agccttctta ctctgcggat taaggtgaag
     1021 aaagggctgc aggtgatagc tgcccgccca gcccagccca ccctctggac tgctaagtta
     1081 gaccgcttca agggctcaaa gcaccacacc agcctgatca cctgtcaccg tgctgggcct
     1141 gcagggccag attccagccc ccttgaactg tccgagttcc tgtgggtgga ctttgcagtg
     1201 gagaacagca ctggtggggg tgtggcagtc actcgccctg tcacgtggca gctggagtac
     1261 ccaggtcagg cccccgaagc agagaaggac aaaatggtgt gggagatcct ggtgtctgag
     1321 cgggacatca gagccctcat ccctctggcc aaggctgagg agctggtgaa cacggctcca
     1381 ttgactggag tgccccagcg tattccggtg cggctcgtca ctgtggacag tgggggagcc
     1441 ttggaggagg tgacagagca cattggctgt gagtcagcca atacacaggt cctgcaggta
     1501 tctgaggcct gtgatgctgt gttcgtggct ggccaggaga gccggggtgc caagggggtg
     1561 agggtggact tctggtggcg ccgacttcgg gcctcactaa agctgactgt atgggcccca
     1621 ctcctgccct tgcgcattga gctgactgac accactctgg aacaaatccg aggctggagg
     1681 gtcccaggct cagcagaagg gcagctggag cctgagactg ctgctgagga ggtggagcgg
     1741 cgctcccgtg gctgccgcct gcagtaccag agagctggtg tgcgcttctt ggtgcccttt
     1801 gcggctcacc cgctggacgg tggccgtcgc ctcacccacc tactcggtcc tgactggttg
     1861 ctggatgtga gtcacctcgt ggcagcccat gcccatgtgc aagatcctcg catagcctcc
     1921 ttggaaggtg gccgcatcct agtgggacgg gagcctggag tcacctctat cgaggttcgt
     1981 tccccgctgt ctgacgccat cctgggggag caggcactgg ctgtgacaga cgacaaggtc
     2041 tcagtgctgg atctgcgagt acagccggtg atgggcatct cactgtcctt gagccggggc
     2101 atgtcccacc ctggagaagt cacagccaca tgctgggccc agtcagctct tccagcccca
     2161 aagcaggagg tggccctctc cctgtggctg tccttctctg accacacttt ggccccagcc
     2221 gagctctacg accgcaatga cctggggctg tcggtctcag ctgaggagcc cagtgctgtt
     2281 ctgccagccg aagagcaggg agcccagctt ggtgtggtgg tgagtggtgt gggtgccgaa
     2341 gggctgcccc tacacgtggc tctgcaccca cccgaaccct gccgccgggg ccgccatcgc
     2401 gttcccctgg catcaggcac cgcctggctg gggttgcccc ctttgcccac accagttcct
     2461 gccctcccat ccagccctgt ccggacctca ccgttcacag aagccacggt ggagggaaag
     2521 cggcagatag caggtgatat ggggggccat gtgggtatta ggggcaagtt tgagcgggca
     2581 gaggaagaag ctgggaagga agaaaatgag gccaaagaag aggaggaaga tgaggaagag
     2641 atggtgcctg cccctcagcg tgtcaccgac ctagagctgg ggatgtatgc tcttctgggc
     2701 atcttctgtt tggccatcct catcttcctg gtcaatggtg tggtctttgt gttgcgctac
     2761 cagcgcaaag agcctccaga cagcgctaca gaccctgcct cccctcagcc acataactgg
     2821 gtctggctgg gcaccaatca ggaggaactg agtcggcagc tggaccgatg ctcttcctcg
     2881 ggtccaccca agggggaggg gggctgccct tgtgaaagtg gggcaggagg ggatgcctca
     2941 accgtggccc ccagtgcttc agagagccct gctggctcct cgagcaccct ggcccgcaaa
     3001 gaagccgggg gacgtcggaa gcgagtcgag tttgtgacat ttgcaccagc acccccaacc
     3061 cagccgcctg aggagcctgt aggggccccc gctgtacagt ccatcctggt ggcaggtgag
     3121 gaggacatcc gctgggtgtg cgaggacatg gggctgaagg acccagagga gcttcgaaac
     3181 tacatggaga ggatccgggg cagctcctga ccactccctg acctgccagg ggcagcttgg
     3241 cccaccagct caggcactgg gaccaatggg atcgctggct aatcgtcttg cctgaccctc
     3301 attctcatcc tctggtgctt gttgatctga gtcccctgct gggtcccctc ggggaccccg
     3361 tcccaggccc ctttcacccc caccccttgt catggactat ggtcaagagg gagggcgcat
     3421 gccccttatt tatgggaacc acttcattct actgttgggt acagaataaa tgagaaaaga
     3481 atgggcataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3541 aaa
//
