LOCUS       NM_026698               2389 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 129 (Tmem129), transcript
            variant 1, mRNA.
ACCESSION   NM_026698 XM_620182
VERSION     NM_026698.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2389)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275213.1, AK002836.1 and AC162898.10.
            
            On Oct 13, 2017 this sequence version replaced NM_026698.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094042.1, AK002836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BY275213.1         2-99
            99-302              AK002836.1         3-206
            303-303             AC162898.10        34016-34016         c
            304-355             AK002836.1         208-259
            356-357             AC162898.10        32137-32138         c
            358-1339            AK002836.1         262-1243
            1340-2389           AC162898.10        29557-30606         c
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..2389
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="transmembrane protein 129"
                     /db_xref="GeneID:68366"
                     /db_xref="MGI:MGI:1915616"
     exon            1..355
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1239
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TM129; RING-type E3 ubiquitin
                     transferase TM129"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TM129 isoform a"
                     /protein_id="NP_080974.2"
                     /db_xref="CCDS:CCDS19206.1"
                     /db_xref="GeneID:68366"
                     /db_xref="MGI:MGI:1915616"
                     /translation="MDSPEVTFTLAYLVFAVCFVFTPNEFYSAGLTVQNLLSGWLGSE
                     DAAFVPYHLRRTSATLLCHSLLPLGYYMGMCFAASEKQLYSPGQAPEAWQLFLLLAVT
                     LPLLSCTLIYYWSWDRWTRHPLAQTLALYALPQSGWQAVASSINTEFRRIDKFATGAP
                     GARVIVTDTWVMKVTTYRVHVAQQQDVHLTVTESRQHDLSPDSNLPVQLLTIRVASTS
                     PGTQPFDIRLNSSEYGELCEKLHAPIRSAANVVIRQSLGDLFLETFASHVEVNPAYSV
                     PSNQELEPCIGCMQTRASVKLVKTCQEPAVGECQQCYCRPMWCLTCMGKWFASRQDPQ
                     RPDTWLASRVPCPTCRARFCILDVCCVR"
     exon            356..830
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            831..990
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2389
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1390..1395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1414
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="major polyA site"
     regulatory      2331..2336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="hexamer: AATAAA"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2382
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
     polyA_site      2389
                     /gene="Tmem129"
                     /gene_synonym="0610039G24Rik; 2410015J15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agattcgcag gatgccccgc cagtagccgg acttggactc cgtttcccag agtgccccgc
       61 gggcgatctg acggcggtgg ctgcggcaac aaaccaactg tccagaactg gactctcctg
      121 cctctgcacg gcccagtgag cggtggcggg atggacagcc ctgaggtgac cttcacgttg
      181 gcctacctgg tcttcgcagt gtgcttcgtg ttcacgccca acgagttcta ctcggccggg
      241 ctcacagtgc agaatctgtt gtcgggctgg ctgggcagcg aggacgccgc cttcgtacct
      301 taccaccttc gccgcacttc cgccacacta ctgtgtcact cactgctgcc gttaggctac
      361 tacatgggca tgtgctttgc agcctcagaa aagcagctct actccccagg tcaggcccca
      421 gaagcctggc aactcttcct tctcctggct gtgacccttc cccttctctc ctgtaccctg
      481 atctactact ggtcctggga taggtggacc cgacacccac tggcccaaac cctggccctc
      541 tatgcccttc cacagtctgg ttggcaggct gtcgcttctt ccatcaacac agagttccga
      601 cggattgaca agtttgctac aggggcacct ggtgcccgag tgattgtgac agacacatgg
      661 gtaatgaagg tgaccacata ccgtgtacat gtggctcagc aacaggatgt tcacttgact
      721 gtgacagagt cacggcagca tgatctctcg ccagactcaa acctacctgt gcagcttctt
      781 actatacgtg tggcaagcac cagccctggc acacagccct ttgatattcg gctgaattca
      841 tcagaatatg gcgaactatg tgagaagctc cacgccccaa tccgaagtgc agccaatgtg
      901 gtcatccgcc agagcctggg ggacctcttc ctagaaacat ttgcttccca tgtggaggtc
      961 aacccagcct attcagtacc cagcaaccag gagctggagc cctgtatagg ctgcatgcaa
     1021 acacgggcca gcgtgaagtt ggtgaagacc tgtcaggagc cagcggtcgg cgagtgccag
     1081 cagtgttact gccgacccat gtggtgtctc acttgcatgg gcaagtggtt tgccagccgc
     1141 caggatcccc agcgccctga cacttggcta gccagccgtg tgccctgccc cacttgccgt
     1201 gcccgcttct gcatcctgga tgtgtgctgt gtacgctgag catcacagta tgttctgtgt
     1261 ctccactagc cacttctggg gagtgcctga agctctttga ctttgacaag aggttctagt
     1321 taaagcacac acttaatcta cagccactct ctaccttgag tctatctatg gtcagttgaa
     1381 gagttttaga agaaattctc atggaaatgc cctatccctg gaccttcagc ctcttctctt
     1441 ccagtttacc tccaggtggg gctgatatgc cacataggat gctccaaagc cccaagacat
     1501 tggagtttgg ctcaagagcc tttatttggc ctgtttgcct taattctatt acatagcata
     1561 cctgtatttc agttaaaaac cagaccctat ggtgttgggt agacactgac agttgagagg
     1621 gtcaccaggg tgccactcta gtgtgaagtc ctcttctagg gtatcctggt gactgtggct
     1681 agccaagggg ccacttcttg gtaggaaggt atgacagagt actttcccaa gttcctcacg
     1741 agggttgcat atgctttaga gggtccacaa tgcttttgtt gtcttgtcct gcttctctag
     1801 tccaggggag accaaaagct catactccta accctaggaa agggttttag ggagccaagg
     1861 accagagagc cacaggacta tccagaaaga aacccatcag gggtgtagca cagggttagc
     1921 caagcccctg tggggtgctt ggatcaggag aggatacctc agtggttaag gttctgatgg
     1981 acgcacatat acatagatgt actcacttat ctatggtaca gatgggtggg gaagaggttg
     2041 ctctttactc tccatctctg acacaaagtg tagctgctag agggatgacc tctccttcaa
     2101 cttgtcctga agcacttaca tttagttgtt gaaagcagta gtagcagacc aagctagccc
     2161 cttatccagc caacactgca cctaacccca gggatttgct accagagcaa actcagttct
     2221 gcctgtccct gaagtatgac caggagacag ccagtttcaa gggctgtctg cctagcagag
     2281 gccaagtggt ttgaagttat ttttaaccac agaagagtta attttataca aataaatgta
     2341 aatgtagtta aatgatacag tatttaataa agtgttcctt ttcaagtga
//
