LOCUS       NM_175145               4772 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 127 (Tmem127), transcript
            variant 1, mRNA.
ACCESSION   NM_175145
VERSION     NM_175145.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4772)
  AUTHORS   Guo,Q., Cheng,Z.M., Gonzalez-Cantu,H., Rotondi,M.,
            Huelgas-Morales,G., Ethiraj,P., Qiu,Z., Lefkowitz,J., Song,W.,
            Landry,B.N., Lopez,H., Estrada-Zuniga,C.M., Goyal,S., Khan,M.A.,
            Walker,T.J., Wang,E., Li,F., Ding,Y., Mulligan,L.M., Aguiar,R.C.T.
            and Dahia,P.L.M.
  TITLE     TMEM127 suppresses tumor development by promoting RET
            ubiquitination, positioning, and degradation
  JOURNAL   Cell Rep 42 (9), 113070 (2023)
   PUBMED   37659079
REFERENCE   3  (bases 1 to 4772)
  AUTHORS   Srikantan,S., Deng,Y., Cheng,Z.M., Luo,A., Qin,Y., Gao,Q.,
            Sande-Docor,G.M., Tao,S., Zhang,X., Harper,N., Shannon,C.E.,
            Fourcaudot,M., Li,Z., Kasinath,B.S., Harrison,S., Ahuja,S.,
            Reddick,R.L., Dong,L.Q., Abdul-Ghani,M., Norton,L., Aguiar,R.C.T.
            and Dahia,P.L.M.
  TITLE     The tumor suppressor TMEM127 regulates insulin sensitivity in a
            tissue-specific manner
  JOURNAL   Nat Commun 10 (1), 4720 (2019)
   PUBMED   31624249
  REMARK    GeneRIF: Hepatic transmembrane protein 127 (Tmem127) expression is
            increased in insulin-resistant states.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4772)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4772)
  AUTHORS   Qin,Y., Deng,Y., Ricketts,C.J., Srikantan,S., Wang,E., Maher,E.R.
            and Dahia,P.L.
  TITLE     The tumor susceptibility gene TMEM127 is mutated in renal cell
            carcinomas and modulates endolysosomal function
  JOURNAL   Hum Mol Genet 23 (9), 2428-2439 (2014)
   PUBMED   24334765
REFERENCE   6  (bases 1 to 4772)
  AUTHORS   Thomas,J.W. and Green,E.D.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845368.6.
            
            On Apr 25, 2018 this sequence version replaced NM_175145.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165880.1, BC049832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL845368.6         53048-53184
            138-455             AL845368.6         53592-53909
            456-620             AL845368.6         61105-61269
            621-4772            AL845368.6         62057-66208
FEATURES             Location/Qualifiers
     source          1..4772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.87 cM"
     gene            1..4772
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="transmembrane protein 127"
                     /db_xref="GeneID:69470"
                     /db_xref="MGI:MGI:1916720"
     exon            1..137
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            138..455
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..928
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 127 isoform 1"
                     /protein_id="NP_780354.1"
                     /db_xref="CCDS:CCDS16697.1"
                     /db_xref="GeneID:69470"
                     /db_xref="MGI:MGI:1916720"
                     /translation="MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITAL
                     CTALAEPAWLHIHGGTCSRQELGVSDVLGYVNPDLLKDFCMNPQTVLLLRVIAAFCFL
                     GILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQ
                     HKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEEND
                     PYPAEYEVINQFQPPPAYTP"
     exon            456..620
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..4772
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4399..4404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4428
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="major polyA site"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4771
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
ORIGIN      
        1 ggaggaagcc ggaagtgcat cggccagggt ccgtctgggc gttgcgggtt tggggcctgg
       61 gatcgtttgg cccgggcagc taagaagcct gtgaccgggc ggagcggcgc catcccagcc
      121 ctgaggcctg ctgaccgaca ggctctgcgc gccccgctga ggtcggcggc caccaccaac
      181 gaccgcagag ctacagcggg cagccccggg catgtatgcc cctggaggtg ccgggctgcc
      241 gggagggcgc cggcggagaa gcccgggaag cagcgctctt cccaagcagc cggagcggag
      301 cctggcctcg gccctgcctg gcgccctgtc catcacagcg ctgtgcactg ccctcgcgga
      361 gcccgcttgg ttgcacatcc atggaggcac ctgttcccgc caggagctgg gggtctcgga
      421 cgtgctgggc tatgtaaacc cggatctgct aaaagatttc tgcatgaacc cccagacagt
      481 gctgctcctg agggtcatcg ctgctttctg cttcctgggc atcctgtgta gtctctctgc
      541 attccttttg gatgtctttg ggcccaagca tccagctctg aagattactc gtcggtatgc
      601 ctttgctcac atcctcactg tcctacagtg tgctaccgtc attggctttt cctattgggc
      661 ttctgagctc atcctggccc agcagcaaca gcataagaag taccacggct cccaagtcta
      721 tgtcaccttt gctgttagct tctacttggt ggcaggagct ggtggagcct caatcctggc
      781 tactgcagcc aacctcctgc gccactaccc aacagaggaa gaagaacaag cactggagct
      841 actatctgag atggaggaga atgaccccta cccagcagag tatgaggtca tcaaccaatt
      901 ccagccaccc cctgcctata caccctaatg ccagccgggg ctctcttcct cagcagccca
      961 tcccccagtg ccacagctcc tcttacaccc agaggagcca cttcccccag caggtctcat
     1021 tggtaggacc ctgaccatct tcaccaaatc ttccccagga gacactctgc ctttaggttt
     1081 gtccatgtgt ccctgctctg cagagccggg actctgattt catataatgt actctttccc
     1141 ctcccagtac cctctgctcc tttcctattc actagctcct tccaaccagg gatggtcaga
     1201 taagtttcct ctctctgtgg gccatgtctt tgggactggg actttccttg ggttgctgct
     1261 ggtagtggtc agtccctgag agaggtacca acagagcaca aggggaaggg actatgccat
     1321 gcaagttcac tttgccaggc ccagcatttg tgccacttgt gtatctctgg gctgaccctc
     1381 attccttcta gagtgcccag gcccagttgt ccacgttgtg gattctctgc actttagtct
     1441 ccaggcactc ctcatacatg atctggtttt ctggagagaa ggaatcactg ctggggagca
     1501 atgcaactgt tctcctgccc tgccctggct tcctgtggtt agaaccaggc aaggaagcag
     1561 aaccagacaa gagactgctc ctatcaagga ccccagtgaa ggggactgag tgccctagcc
     1621 tcttcaccgt ttaatgtgag tggttttgaa agaaaaaaaa caaaaccaag caatagcagc
     1681 catactcttt ctaaaatagg gataaggctg ttgttgttca gaaatgtagc ccatccctta
     1741 tggctctgca atattttgga ccatagcacc ctctgagcct atagtcacgc cttcccagtt
     1801 tccaacagta tgcaggcttt ctgtcctggc tccttcttcc aggcagctgt gactccctgg
     1861 ggcctttctg tggaactagg gccacatggc ccccacgggg ctgagaacta tggcctgctg
     1921 gctggccagc gtggtgctcc tcagaactat ggcactgaga tgtaacctgg cctcagttca
     1981 gggacagggg ccaagcaggg caggaccctc cactctccac ataggtactc cacccagagg
     2041 cccaccaggt tggtgtcagg gccctgtcag atgtgcaggc ctggctgtag ccttcagagt
     2101 caatgtggcc ctagactgtg acttggggct acagcttgct gcatgcccct cttccgtttt
     2161 ggaatgtatg ctggtcttgt ggtgtgctac tgggctgtta ctctaggtat tctgtttgcc
     2221 ttgggtccag tttttttttt tttttgaggg gggggggtgt tgggtttttt tttccctggt
     2281 gatctggggc acaaggtagg taagacctga gaggcctgca gcatggatcc aggtaggcaa
     2341 gctgttcttg ttccgttatg agcatctctg gagtaatagt ctagtgttag ctgaagggaa
     2401 gatgaattcc aatctctgcc ctcccataag acaacaaaca ttttgaacaa gaatggagaa
     2461 tgaatacagt tgttgacctg tgactacaag aagactgtca actcgccatt ctttggccag
     2521 aaagaatggt gaatatgtgg acaaatgcct atgcagatga agaccaagcg tgcccacaag
     2581 aaggcatctg cttggagttc cctgctgcaa tgccaaagtg tgccccagta tgactctccc
     2641 attttcccag acccctctcg gaggcaagaa aggctgccag gtgatgcctg agcacaaagt
     2701 caaggagcta aattaaggct acctttctgt gaagttctga gctcatcatt ggcaggttgc
     2761 tgaagtgtgt agccagctct ctctaacatg gcacctgagg gagcaggcca gaagatcagg
     2821 caccaaacat gcatgccaaa gtgaatgagg acttgatcct gcggaccgtt ccttgtgatt
     2881 tggaacccac tttttactag cttcctgttc ctgggccttt cttcctcctc tccctgccat
     2941 tctgacactg atagtttgtc atataaaggt ccctggttgt gtttcccccc caaggggaaa
     3001 aattaaaatg caaaacaaaa accaggaact acaaatgaga acgcaaatgc cagtggctgc
     3061 ctgtcatttc tgttacaatt ctccagatgt ttgttttctt cctcccagag aagcagaagg
     3121 cattcactga cgaagcttgt aatatgaaac aaagtgagga gggacttggc atgcgcctgc
     3181 accacgcaca tttggatcct tgggagcctc ccactcctgg cacctttcac agaggaagtt
     3241 ctcaaagccc acagctagat atagtaggtt gctctgccca aaatctcaac tacagacctt
     3301 gagccgcctc tctctgcatg tcctgattag ctgcagaaga gctgtttcag acctctgctg
     3361 gtacttactg ggagaagcct gaaaataaaa atgagcaaga cctgcagagt cgctcttcca
     3421 ggcagttgat gggtgatacc ttgatggcta cccacagtct tagttcattc attctcaacc
     3481 catacactgg accccaagtg tgtgaaagca tttagggctg tctttgggaa atattccatt
     3541 cctagcagga tgcatgtctt tcctggaaac tgataatctt ctcaatacat gttcgttcac
     3601 acacttatat gaagggtcca ttggattatg cacaaaatga aattatgagc cccatgaaag
     3661 aaatagagtg cctgacagga cctctctcct aggattcttt ccttagctca ggagatggac
     3721 tcagccacaa ggaaacagtg aaatgagtag tctcctggac actttgggaa atcctgtgct
     3781 agaaatggga ggctggatct aaccagaaaa attaccaacg tcttccaggt gggaagctga
     3841 tggagctggg ttggtgtgcg agagcatttc agggaggggc tgttccctct gagggaatgg
     3901 cagtagtggt caggttgtag tgtgaagtgg gacgctgaag gcctatctga tgtttctcaa
     3961 agcaatggga agccatagga gggtgcttaa aaaaagggat ccagttttat ggtgatgtgg
     4021 aggggctatt gatattaagt aaagtacctg aaagtgtgag aattgggggg acaggtatac
     4081 atcatgtgga ggaccctcag gcctggtagg aggagagaat gatcactgcc aggtgctggg
     4141 gtagagagcc caggaacatc cttgtcatat gcactagaag atgggatcaa ccttgtagct
     4201 caagtgtgcc tcaaaagaga gctatgttgg gtaaggacag cagagagagg cctctgaaaa
     4261 cacaaagtgg ctgttgtatc tgggggaaag gtcattctct ctagatgact ccaaaatctc
     4321 cagctggttt cttactcaga ggtacctggg ccaggacagt atggaataca aggttctgtg
     4381 gggagaaaaa aaagaactaa taaactttat agcctttgtt ttcaaatagc ctgtagtctt
     4441 cctgtgcctt tcttgtggga gtaccattgt aactagctca ggcaggacat acagagaaga
     4501 tgactccaat ctgggtgaat ctgcttgaaa tgagacaaac tctttgggga tgtcagttcc
     4561 ttatgagatg tggggaaatg cttgacttca atcctggaat aggggctctt tcttcagaag
     4621 agattcagag tggactggct tgtccgttat actgagtggg aaaacccaag cctggtgagg
     4681 tgccttttcc aaagatgctg aaggggaggt agaggccatc tctgcccaat catgtgtctg
     4741 aggggttagt taataaaaga acttccaaag ag
//
