LOCUS       NM_001362704            4454 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 127 (Tmem127), transcript
            variant 2, mRNA.
ACCESSION   NM_001362704
VERSION     NM_001362704.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   Guo,Q., Cheng,Z.M., Gonzalez-Cantu,H., Rotondi,M.,
            Huelgas-Morales,G., Ethiraj,P., Qiu,Z., Lefkowitz,J., Song,W.,
            Landry,B.N., Lopez,H., Estrada-Zuniga,C.M., Goyal,S., Khan,M.A.,
            Walker,T.J., Wang,E., Li,F., Ding,Y., Mulligan,L.M., Aguiar,R.C.T.
            and Dahia,P.L.M.
  TITLE     TMEM127 suppresses tumor development by promoting RET
            ubiquitination, positioning, and degradation
  JOURNAL   Cell Rep 42 (9), 113070 (2023)
   PUBMED   37659079
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Srikantan,S., Deng,Y., Cheng,Z.M., Luo,A., Qin,Y., Gao,Q.,
            Sande-Docor,G.M., Tao,S., Zhang,X., Harper,N., Shannon,C.E.,
            Fourcaudot,M., Li,Z., Kasinath,B.S., Harrison,S., Ahuja,S.,
            Reddick,R.L., Dong,L.Q., Abdul-Ghani,M., Norton,L., Aguiar,R.C.T.
            and Dahia,P.L.M.
  TITLE     The tumor suppressor TMEM127 regulates insulin sensitivity in a
            tissue-specific manner
  JOURNAL   Nat Commun 10 (1), 4720 (2019)
   PUBMED   31624249
  REMARK    GeneRIF: Hepatic transmembrane protein 127 (Tmem127) expression is
            increased in insulin-resistant states.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Qin,Y., Deng,Y., Ricketts,C.J., Srikantan,S., Wang,E., Maher,E.R.
            and Dahia,P.L.
  TITLE     The tumor susceptibility gene TMEM127 is mutated in renal cell
            carcinomas and modulates endolysosomal function
  JOURNAL   Hum Mol Genet 23 (9), 2428-2439 (2014)
   PUBMED   24334765
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   Thomas,J.W. and Green,E.D.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845368.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.6026979.1, BI663765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL845368.6         53048-53184
            138-302             AL845368.6         61105-61269
            303-4454            AL845368.6         62057-66208
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.87 cM"
     gene            1..4454
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="transmembrane protein 127"
                     /db_xref="GeneID:69470"
                     /db_xref="MGI:MGI:1916720"
     exon            1..137
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            138..302
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..610
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 127 isoform 2"
                     /protein_id="NP_001349633.1"
                     /db_xref="CCDS:CCDS89551.1"
                     /db_xref="GeneID:69470"
                     /db_xref="MGI:MGI:1916720"
                     /translation="MNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRR
                     YAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGA
                     SILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP"
     exon            303..4454
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4081..4086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4110
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="major polyA site"
     regulatory      4434..4439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4453
                     /gene="Tmem127"
                     /gene_synonym="2310003P10Rik"
ORIGIN      
        1 ggaggaagcc ggaagtgcat cggccagggt ccgtctgggc gttgcgggtt tggggcctgg
       61 gatcgtttgg cccgggcagc taagaagcct gtgaccgggc ggagcggcgc catcccagcc
      121 ctgaggcctg ctgaccgatt tctgcatgaa cccccagaca gtgctgctcc tgagggtcat
      181 cgctgctttc tgcttcctgg gcatcctgtg tagtctctct gcattccttt tggatgtctt
      241 tgggcccaag catccagctc tgaagattac tcgtcggtat gcctttgctc acatcctcac
      301 tgtcctacag tgtgctaccg tcattggctt ttcctattgg gcttctgagc tcatcctggc
      361 ccagcagcaa cagcataaga agtaccacgg ctcccaagtc tatgtcacct ttgctgttag
      421 cttctacttg gtggcaggag ctggtggagc ctcaatcctg gctactgcag ccaacctcct
      481 gcgccactac ccaacagagg aagaagaaca agcactggag ctactatctg agatggagga
      541 gaatgacccc tacccagcag agtatgaggt catcaaccaa ttccagccac cccctgccta
      601 tacaccctaa tgccagccgg ggctctcttc ctcagcagcc catcccccag tgccacagct
      661 cctcttacac ccagaggagc cacttccccc agcaggtctc attggtagga ccctgaccat
      721 cttcaccaaa tcttccccag gagacactct gcctttaggt ttgtccatgt gtccctgctc
      781 tgcagagccg ggactctgat ttcatataat gtactctttc ccctcccagt accctctgct
      841 cctttcctat tcactagctc cttccaacca gggatggtca gataagtttc ctctctctgt
      901 gggccatgtc tttgggactg ggactttcct tgggttgctg ctggtagtgg tcagtccctg
      961 agagaggtac caacagagca caaggggaag ggactatgcc atgcaagttc actttgccag
     1021 gcccagcatt tgtgccactt gtgtatctct gggctgaccc tcattccttc tagagtgccc
     1081 aggcccagtt gtccacgttg tggattctct gcactttagt ctccaggcac tcctcataca
     1141 tgatctggtt ttctggagag aaggaatcac tgctggggag caatgcaact gttctcctgc
     1201 cctgccctgg cttcctgtgg ttagaaccag gcaaggaagc agaaccagac aagagactgc
     1261 tcctatcaag gaccccagtg aaggggactg agtgccctag cctcttcacc gtttaatgtg
     1321 agtggttttg aaagaaaaaa aacaaaacca agcaatagca gccatactct ttctaaaata
     1381 gggataaggc tgttgttgtt cagaaatgta gcccatccct tatggctctg caatattttg
     1441 gaccatagca ccctctgagc ctatagtcac gccttcccag tttccaacag tatgcaggct
     1501 ttctgtcctg gctccttctt ccaggcagct gtgactccct ggggcctttc tgtggaacta
     1561 gggccacatg gcccccacgg ggctgagaac tatggcctgc tggctggcca gcgtggtgct
     1621 cctcagaact atggcactga gatgtaacct ggcctcagtt cagggacagg ggccaagcag
     1681 ggcaggaccc tccactctcc acataggtac tccacccaga ggcccaccag gttggtgtca
     1741 gggccctgtc agatgtgcag gcctggctgt agccttcaga gtcaatgtgg ccctagactg
     1801 tgacttgggg ctacagcttg ctgcatgccc ctcttccgtt ttggaatgta tgctggtctt
     1861 gtggtgtgct actgggctgt tactctaggt attctgtttg ccttgggtcc agtttttttt
     1921 tttttttgag gggggggggt gttgggtttt tttttccctg gtgatctggg gcacaaggta
     1981 ggtaagacct gagaggcctg cagcatggat ccaggtaggc aagctgttct tgttccgtta
     2041 tgagcatctc tggagtaata gtctagtgtt agctgaaggg aagatgaatt ccaatctctg
     2101 ccctcccata agacaacaaa cattttgaac aagaatggag aatgaataca gttgttgacc
     2161 tgtgactaca agaagactgt caactcgcca ttctttggcc agaaagaatg gtgaatatgt
     2221 ggacaaatgc ctatgcagat gaagaccaag cgtgcccaca agaaggcatc tgcttggagt
     2281 tccctgctgc aatgccaaag tgtgccccag tatgactctc ccattttccc agacccctct
     2341 cggaggcaag aaaggctgcc aggtgatgcc tgagcacaaa gtcaaggagc taaattaagg
     2401 ctacctttct gtgaagttct gagctcatca ttggcaggtt gctgaagtgt gtagccagct
     2461 ctctctaaca tggcacctga gggagcaggc cagaagatca ggcaccaaac atgcatgcca
     2521 aagtgaatga ggacttgatc ctgcggaccg ttccttgtga tttggaaccc actttttact
     2581 agcttcctgt tcctgggcct ttcttcctcc tctccctgcc attctgacac tgatagtttg
     2641 tcatataaag gtccctggtt gtgtttcccc cccaagggga aaaattaaaa tgcaaaacaa
     2701 aaaccaggaa ctacaaatga gaacgcaaat gccagtggct gcctgtcatt tctgttacaa
     2761 ttctccagat gtttgttttc ttcctcccag agaagcagaa ggcattcact gacgaagctt
     2821 gtaatatgaa acaaagtgag gagggacttg gcatgcgcct gcaccacgca catttggatc
     2881 cttgggagcc tcccactcct ggcacctttc acagaggaag ttctcaaagc ccacagctag
     2941 atatagtagg ttgctctgcc caaaatctca actacagacc ttgagccgcc tctctctgca
     3001 tgtcctgatt agctgcagaa gagctgtttc agacctctgc tggtacttac tgggagaagc
     3061 ctgaaaataa aaatgagcaa gacctgcaga gtcgctcttc caggcagttg atgggtgata
     3121 ccttgatggc tacccacagt cttagttcat tcattctcaa cccatacact ggaccccaag
     3181 tgtgtgaaag catttagggc tgtctttggg aaatattcca ttcctagcag gatgcatgtc
     3241 tttcctggaa actgataatc ttctcaatac atgttcgttc acacacttat atgaagggtc
     3301 cattggatta tgcacaaaat gaaattatga gccccatgaa agaaatagag tgcctgacag
     3361 gacctctctc ctaggattct ttccttagct caggagatgg actcagccac aaggaaacag
     3421 tgaaatgagt agtctcctgg acactttggg aaatcctgtg ctagaaatgg gaggctggat
     3481 ctaaccagaa aaattaccaa cgtcttccag gtgggaagct gatggagctg ggttggtgtg
     3541 cgagagcatt tcagggaggg gctgttccct ctgagggaat ggcagtagtg gtcaggttgt
     3601 agtgtgaagt gggacgctga aggcctatct gatgtttctc aaagcaatgg gaagccatag
     3661 gagggtgctt aaaaaaaggg atccagtttt atggtgatgt ggaggggcta ttgatattaa
     3721 gtaaagtacc tgaaagtgtg agaattgggg ggacaggtat acatcatgtg gaggaccctc
     3781 aggcctggta ggaggagaga atgatcactg ccaggtgctg gggtagagag cccaggaaca
     3841 tccttgtcat atgcactaga agatgggatc aaccttgtag ctcaagtgtg cctcaaaaga
     3901 gagctatgtt gggtaaggac agcagagaga ggcctctgaa aacacaaagt ggctgttgta
     3961 tctgggggaa aggtcattct ctctagatga ctccaaaatc tccagctggt ttcttactca
     4021 gaggtacctg ggccaggaca gtatggaata caaggttctg tggggagaaa aaaaagaact
     4081 aataaacttt atagcctttg ttttcaaata gcctgtagtc ttcctgtgcc tttcttgtgg
     4141 gagtaccatt gtaactagct caggcaggac atacagagaa gatgactcca atctgggtga
     4201 atctgcttga aatgagacaa actctttggg gatgtcagtt ccttatgaga tgtggggaaa
     4261 tgcttgactt caatcctgga ataggggctc tttcttcaga agagattcag agtggactgg
     4321 cttgtccgtt atactgagtg ggaaaaccca agcctggtga ggtgcctttt ccaaagatgc
     4381 tgaaggggag gtagaggcca tctctgccca atcatgtgtc tgaggggtta gttaataaaa
     4441 gaacttccaa agag
//
