LOCUS       NM_026734                858 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus transmembrane protein 126B (Tmem126b), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_026734 XM_133645
VERSION     NM_026734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Ruan,X.H., Ma,T. and Fan,Y.
  TITLE     Ablation of TMEM126B protects against heart injury via improving
            mitochondrial function in high fat diet (HFD)-induced mice
  JOURNAL   Biochem Biophys Res Commun 515 (4), 636-643 (2019)
   PUBMED   31178133
  REMARK    GeneRIF: TMEM126B has a role in protecting against heart injury via
            improving mitochondrial function in high fat diet-induced mice
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Weihong,C., Bin,C. and Jianfeng,Y.
  TITLE     Transmembrane protein 126B protects against high fat diet
            (HFD)-induced renal injury by suppressing dyslipidemia via
            inhibition of ROS
  JOURNAL   Biochem Biophys Res Commun 509 (1), 40-47 (2019)
   PUBMED   30580996
  REMARK    GeneRIF: This study identified Tmem126b as a positive regulator for
            the progression of chronic kidney disease induced by high-fat diet
            through meditating Nrf-2 expression.
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Gendrel,A.V., Tang,Y.A., Suzuki,M., Godwin,J., Nesterova,T.B.,
            Greally,J.M., Heard,E. and Brockdorff,N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100322.8.
            
            On Aug 22, 2018 this sequence version replaced NM_026734.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049680.1, BY703516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC100322.8         137438-137538       c
            102-223             AC100322.8         134141-134262       c
            224-417             AC100322.8         132308-132501       c
            418-529             AC100322.8         131113-131224       c
            530-858             AC100322.8         130376-130704       c
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.6 cM"
     gene            1..858
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /note="transmembrane protein 126B"
                     /db_xref="GeneID:68472"
                     /db_xref="MGI:MGI:1915722"
     exon            1..101
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..713
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /codon_start=1
                     /product="complex I assembly factor TMEM126B,
                     mitochondrial"
                     /protein_id="NP_081010.1"
                     /db_xref="CCDS:CCDS21448.1"
                     /db_xref="GeneID:68472"
                     /db_xref="MGI:MGI:1915722"
                     /translation="MAASQRPSWSESKVAGVVQEGNREAPQDIKMALYKHGQLIPSLG
                     DAKFRSPIISEIIEKKFEHYRNDKTLNIHGTLVFGTSSSLSGIMANLVFRNSFKVKYE
                     ALKTYASLTTLPVLATIVSYKLFVTDALQSGDISKESCVLRSALIGMACGVSYPSALA
                     FYKNGRLAVKYQTVPLPPKGRVMLHWLLLCQTGMKAMAIPLFFQIVMGAFTGLHHYNI
                     CEKPRARLVPDD"
     exon            102..223
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            224..417
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            418..529
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            530..858
                     /gene="Tmem126b"
                     /gene_synonym="1110001A23Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcacgtg aggcgctaag atggcggcgt cccagcgacc aagttggtcc gagtcgaagg
       61 ttgctggtgt tgtgcaggag ggaaataggg aagcacccca ggacatcaag atggcacttt
      121 ataaacatgg tcagctgatt ccttccctag gagatgcaaa gttcagaagc ccgataatct
      181 ctgaaattat agaaaagaag tttgaacatt atagaaacga caagacttta aatatacatg
      241 gaactttggt ctttggaaca agtagtagtt tgtctggcat aatggcaaac ttagttttcc
      301 gaaacagttt caaggttaaa tatgaagctt tgaagaccta tgcatccctg actacacttc
      361 cagttttggc taccatcgtt tcttacaagc tctttgtaac agatgctttg caatcaggtg
      421 acataagcaa ggaaagctgt gttctgagga gcgcactaat tggcatggca tgcggcgttt
      481 cctaccccag tgctttggct ttctataaaa atggacgttt ggcagttaag tatcagactg
      541 ttccactgcc accaaaggga agagttatgc tccattggtt gctcctttgt caaactggga
      601 tgaaagcaat ggctattcct ctgttctttc agatagtaat gggagctttt actggcttac
      661 atcattacaa tatatgtgaa aaaccacgtg caaggcttgt gcctgatgat taaccaaaga
      721 ctccatggac tccatggaag ccggttcaat ggcatgaact tctttataga cggactttgc
      781 cactggtcta agagggaaaa ggaacttttg cctggcatat atcagacact cagtaattat
      841 gaatgttata aatgttaa
//
