LOCUS       NM_025460                773 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 126A (Tmem126a), transcript
            variant 1, mRNA.
ACCESSION   NM_025460
VERSION     NM_025460.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 773)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 773)
  AUTHORS   Kim,E.C., Moon,J.H., Kang,S.W., Kwon,B. and Lee,H.W.
  TITLE     TMEM126A, a CD137 ligand binding protein, couples with the TLR4
            signal transduction pathway in macrophages
  JOURNAL   Mol Immunol 64 (2), 244-251 (2015)
   PUBMED   25549946
  REMARK    GeneRIF: TMEM126A contributes to the TLR4 signal up-regulating the
            expression of genes whose products are involved in antigen
            presentation.
REFERENCE   4  (bases 1 to 773)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   5  (bases 1 to 773)
  AUTHORS   Bae,J.S., Choi,J.K., Moon,J.H., Kim,E.C., Croft,M. and Lee,H.W.
  TITLE     Novel transmembrane protein 126A (TMEM126A) couples with CD137L
            reverse signals in myeloid cells
  JOURNAL   Cell Signal 24 (12), 2227-2236 (2012)
   PUBMED   22885069
  REMARK    GeneRIF: TMEM126A binds to the extracellular domain of CD137L and
            is detected on cell surface by flow cytometry, cell surface
            expression of TMEM126A may be essential for CD137L reverse
            signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007559.1 and AC100322.8.
            
            On Jun 5, 2018 this sequence version replaced NM_025460.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023171.1, BG919400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-761               AK007559.1         7-767
            762-773             AC100322.8         112243-112254       c
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 50.59 cM"
     gene            1..773
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /note="transmembrane protein 126A"
                     /db_xref="GeneID:66271"
                     /db_xref="MGI:MGI:1913521"
     exon            1..132
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            133..228
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..730
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /codon_start=1
                     /product="transmembrane protein 126A"
                     /protein_id="NP_079736.1"
                     /db_xref="CCDS:CCDS21447.1"
                     /db_xref="GeneID:66271"
                     /db_xref="MGI:MGI:1913521"
                     /translation="MESHKPSTSKDDLILNIISRKIKQLPESDRNLLEYGSAYIGLNA
                     AFGGLIANSLFRRILNVTQARLASSLPMAVIPFLTANLSYQSLVSLPLSTGDLNCETC
                     TTTRGALVGLVMGGLYPILLAIPVNGGLAARYESSPLPQRGNIFNYWITVSKPVFRKM
                     LFPTLLQTVFASYLGSRQYKLLIKALQLPEPDLEIH"
     exon            229..422
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            423..537
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..773
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      744..749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /note="hexamer: AACAAA"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      765
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /note="major polyA site"
     polyA_site      768
                     /gene="Tmem126a"
                     /gene_synonym="1810020E01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagtcacgt gtgagccaaa gatggagctc agacgaccct agcgaaggtt gcggtagact
       61 cggcgcggga ggacccgggc aagcaccggc ggctggggag gctgccatta gctgccttca
      121 ttctgccgaa tggtccaaga tggaaagtca taaaccaagt actagcaaag atgatttaat
      181 acttaatatc atatccagaa aaattaaaca acttccagaa tcagacagga atctgcttga
      241 atatggatca gcatatattg gacttaatgc tgcttttggg ggcctaatag caaacagtct
      301 atttcggcga atcttgaacg tgacacaagc tcgattagct tctagcttac caatggctgt
      361 gatcccattt ttgacagcaa acctgtccta ccaaagtctt gtaagtttac ctttgagtac
      421 aggtgatttg aactgtgaaa cctgtaccac aacacggggt gcactagttg gtttggttat
      481 gggtggtctg taccctatcc ttttggctat acccgtcaat gggggccttg ctgccaggta
      541 tgaatcaagt cccctcccac agaggggaaa catcttcaac tactggatta cagtttctaa
      601 gcctgtcttt agaaaaatgt tatttcctac tttacttcag actgtgtttg catcctatct
      661 tgggtctaga caatataaac tcctcataaa ggcccttcag ttacctgaac ctgacttaga
      721 aattcattga agcaaatatg tacaacaaaa ataaaatggt gaaaataatc ttg
//
