LOCUS       NM_133739               2881 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 123 (Tmem123), transcript
            variant 1, mRNA.
ACCESSION   NM_133739 XM_001005696
VERSION     NM_133739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Takekoshi,T., Tada,Y., Watanabe,T., Sugaya,M., Hoashi,T.,
            Komine,M., Kawashima,T., Shimizu,T., Hau,C.S., Asahina,A.,
            Yokomizo,T., Sato,S. and Tamaki,K.
  TITLE     Identification of a novel marker for dendritic cell maturation,
            mouse transmembrane protein 123
  JOURNAL   J Biol Chem 285 (41), 31876-31884 (2010)
   PUBMED   20685650
  REMARK    GeneRIF: Tmem123 may be used as a new maturation marker in DCs and
            that this molecule may be closely associated with the cell surface
            expression of CD40.
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Lu,J., Izvolsky,K.I., Qian,J. and Cardoso,W.V.
  TITLE     Identification of FGF10 targets in the embryonic lung epithelium
            during bud morphogenesis
  JOURNAL   J Biol Chem 280 (6), 4834-4841 (2005)
   PUBMED   15556938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY259389.1, AK162610.1, AK150361.1 and AI448519.1.
            
            On Nov 15, 2007 this sequence version replaced NM_133739.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086319.1, AK162610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY259389.1         2-6
            6-1848              AK162610.1         2-1844
            1849-2868           AK150361.1         1797-2816
            2869-2881           AI448519.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2881
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /note="transmembrane protein 123"
                     /db_xref="GeneID:71929"
                     /db_xref="MGI:MGI:1919179"
     exon            1..236
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..733
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /note="porimin; pro-oncosis receptor inducing membrane
                     injury"
                     /codon_start=1
                     /product="porimin precursor"
                     /protein_id="NP_598500.1"
                     /db_xref="CCDS:CCDS22810.1"
                     /db_xref="GeneID:71929"
                     /db_xref="MGI:MGI:1919179"
                     /translation="MALCARAALLLGVLQVLALLGAAQDPTDAQGSASGNHSVLTSNI
                     NITENTNQTMSVVSNQTSEMQSTAKPSVLPKTTTLITVKPATIVKISTPGVLPHVTPT
                     ASKSTPNASASPNSTHTSASMTTPAHSSLLTTVTVSATTHPTKGKGSKFDAGSFVGGI
                     VLTLGVLSILYIGCKMYYSRRGIRYRSIDEHDAII"
     exon            237..287
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            288..554
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..708
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..2871
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2848..2853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2871
                     /gene="Tmem123"
                     /gene_synonym="2310075C12Rik"
                     /note="major polyA site"
ORIGIN      
        1 tatccctatt tggtcactgg ggggactggc ggcggcgtct gcaggggagc ggtaagggcg
       61 gaaggggacg cggagcggtc gcgtgcgcgg agagcagctc tgggcgccgg gcggttgctg
      121 cgggcgctca ggggccctgg gaacaatggc gctgtgcgcg cgggccgcgc tgctgctggg
      181 cgtgctgcag gtgctggcgc tgctaggggc ggcgcaggac ccgaccgacg ctcagggctc
      241 tgcaagtgga aaccactcag tgctgacctc caatattaac ataacagaga ataccaacca
      301 gaccatgagt gtggtttcca accagaccag tgaaatgcag agcaccgcga agccttccgt
      361 actgccaaaa actaccacac ttatcactgt gaaacctgca actattgtta aaatatcaac
      421 cccaggagtc ttaccacatg tgacgcctac tgcctcaaag tctacaccca atgcaagtgc
      481 ttctccaaac tctacccaca cgtcagcatc catgacaacc ccagcccaca gtagtttatt
      541 gacaactgta acggtttcag caactactca tcccaccaaa ggcaaaggat ccaagtttga
      601 tgccggcagc tttgttggtg gtatagtgtt aacactggga gttttatcta ttctctacat
      661 tggatgcaaa atgtattatt caagaagagg cattcggtac cgaagcattg acgaacatga
      721 tgccatcatt taaagtactt cagtggtcaa ggaaagaaga aagactgcag ccttatcaat
      781 tattttggtt tatattagtt taaactatta ttttcttgga agtagtataa acaagtcatg
      841 catataatga gcagtgtatt ccatgaatat ctggaaattt ctcattacta taggtaaagg
      901 gtatagtctg ggtaaaatga atattgggag ctaacaggtc atttatccag tgattgcatt
      961 tcctttagca agacaagtcc tatcttttgg aatatgtgca tggcattgat tggtcatgta
     1021 ggaccaacat cactgagtag cagggcccat ctgcatacag gtgaggagcc tgtcacagca
     1081 tcccggatct cagtatcttc tctgctcaca taaagcactt gagtgccagt cagagctggg
     1141 tgatcctaat tcctgcctca ggttccatgg ttgcgctaac cagctttcaa gtgcagttga
     1201 agtaagtttc agtattttag ggtttagatt agagttcatc tagaagtaga acttgcagtc
     1261 caaatacatc ccccacgacc tcctatgcta acggccaccg agcactggga gctcagactt
     1321 ggctcgtcat ctcccttcaa ctgtcaggat tggtatttct tcctttgtac ataatttagg
     1381 caagctgcag tgcacaccca gcttctcaaa aggcgtagca catgaagact gctgccatgc
     1441 tgctgtggaa acctgtccca gcattgcaaa ctggtcttca cggtcacttg tcagctgagt
     1501 tctagtgaat gtcttttagg caatgtggag ctgcttccca tagttagaat tttttaattg
     1561 aatcagaaat gccattttta aaaagctccg tgatatgacg tcccacccag tgtttagaag
     1621 tctatattga ccggcatcct gcttgttaag ccaggaattg taaagcccag gcctttgaac
     1681 ccacagggta caaatgcagt atttttgtac actgtcaact tagtcagatt tgagaaaatg
     1741 acttttttat actaaagtgt attttggtga attctggttt ccttatcccc aagcctactc
     1801 cttacccttg gaaagagagc tgcatcctga tatttccagg gaagcagcca cgctgtctgt
     1861 ggcactgtaa gttctaaagt ttatactcag gtcaaactca gggccaggtt taacaaagaa
     1921 agtgtttagt tacaaaatac taatatagta tgctattgta aaaggacaaa gtgaattata
     1981 gcaatttcaa aaagtataga aataagccaa aaatatctga atgagcacac atctatgtta
     2041 gaattaaaaa tgtaagtata acttttgtaa tctgcttctg gttttcaaaa caacaaacta
     2101 ccaagaattt ttttatatat aagaatcatt tctacttgct ttacatcggg tccaactgac
     2161 atggtgaggc atggactgct caggttatgt taacacggag agagatgcta ggaaatggac
     2221 catggaatta gactagtttc aaatgagggc tgctgagaaa gccacacttc tcattggctt
     2281 tcagccactg ctctgctttc tatgtgaaat acagttcagg gcctgggggc aacagggtgg
     2341 tgaaagttta actttgtttg tctgttacat tcttggtact tcagtacctg ccagagatcc
     2401 tcttgaacac ttgtttcttt agcactttgg agatataaac cactttataa aggcactgtt
     2461 attatttgcc tcttacattt ccactgagtt gggggttaaa agtaatttac ttattatctt
     2521 ttctaatttg ttactttcaa ataccaggac tttgttgaag agacttcttt ttaatgtata
     2581 aaaattgaat gtttcctaag cataagttgt cttccaagtc tcacttaagc aaatgcttac
     2641 ctttcctagc tttcctagag aatgtgttta ttaagataaa acaatgaata aatccatagg
     2701 aggactaatt caaatatgac agttggcaac atattttatg gtgtggtaat tttgtatctt
     2761 gagaaagact aaagcaaacc cttattgccc tttttctatt ttaacgacca attttggtat
     2821 ttcattgtta ctaagatcta tttttagaat aaaatttgtt ctccattcaa aaaaaaaaaa
     2881 a
//
