LOCUS       NM_033567               5008 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 121B (Tmem121b), mRNA.
ACCESSION   NM_033567
VERSION     NM_033567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5008)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 5008)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   4  (bases 1 to 5008)
  AUTHORS   Bruce,S.R. and Peterson,M.L.
  TITLE     Multiple features contribute to efficient constitutive splicing of
            an unusually large exon
  JOURNAL   Nucleic Acids Res 29 (11), 2292-2302 (2001)
   PUBMED   11376148
REFERENCE   5  (bases 1 to 5008)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078896.23.
            
            On Feb 8, 2019 this sequence version replaced NM_033567.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF277399.1, BC137862.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5008              AC078896.23        105703-110710       c
FEATURES             Location/Qualifiers
     source          1..5008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.95 cM"
     gene            1..5008
                     /gene="Tmem121b"
                     /gene_synonym="Cecr6"
                     /note="transmembrane protein 121B"
                     /db_xref="GeneID:94047"
                     /db_xref="MGI:MGI:2136977"
     exon            1..5008
                     /gene="Tmem121b"
                     /gene_synonym="Cecr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1911
                     /gene="Tmem121b"
                     /gene_synonym="Cecr6"
                     /note="cat eye syndrome critical region protein 6 homolog;
                     cat eye syndrome chromosome region, candidate 6 homolog"
                     /codon_start=1
                     /product="transmembrane protein 121B"
                     /protein_id="NP_291045.1"
                     /db_xref="CCDS:CCDS57446.1"
                     /db_xref="GeneID:94047"
                     /db_xref="MGI:MGI:2136977"
                     /translation="MHPALGHPRALSSAPASFPPPPAAARLQPLFLRGGSSRGRRGSG
                     DSSTSTSTSRGGCGGRRGGGGGSPSSSTGAEREDDDESISISKPLVPAAAALPGPPAQ
                     GGVPVSATAPAAASSTSTPTSSCSMTAADFGAGAAAGTVGGPGSRSAVGAGGTGTGGA
                     ASCCSCCCCCCGRPTRSGRRGRRRGCSPSPGCRWGYQALSVVLLLAQGGLLDLYLIAV
                     TDLYWCSWIATDLVVVVGWAIFFAKNSRGRRGGPANSMHNHHQLHHHSAPPLHLSAAA
                     SAGAGAKARGGRGGSGGSGAGPGTTGAAGEFAFAYLAWLIYSIAFTPKVVLILGTSIL
                     DLIELRAPFGTTGFRLTMALSVPLLYSLVRAISEAGAPPGSAGPLLLQPQQHRAAGCF
                     LGTCLDLLDSFTLVELMLDGRVPLPAHLRYLLIAVYFLTLASPVLWLYELNTATAAPS
                     WGQTSGPGSCSRLLRLLGGCLVDVPLLALRSLLVVSYQQPLSIFMLKNLFFLGCRGLE
                     ALEGCWDRGSWVSPSRARSSYGAPPSAPPPPPPPPPQGGSQRGHLENEGGPHGYVNTL
                     AVASQN"
     regulatory      4982..4987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem121b"
                     /gene_synonym="Cecr6"
                     /note="hexamer: AATAAA"
     polyA_site      4989
                     /gene="Tmem121b"
                     /gene_synonym="Cecr6"
                     /note="major polyA site"
ORIGIN      
        1 agccacccgc ggcttcactc gcccagtccg gccgctccag tccggatctc tctgcctccc
       61 gacccgggtg cgagttccag cagctggcga ggaggcggca gcggctggcc cgggttcccc
      121 tctgccgcct cgtcagcccg aggttgacgg ggagagagcg gccgggcagc ccctggagcc
      181 cctccgagga caatgcaccc ggcgctgggc caccctcgcg cgctctcgtc cgcgcccgcc
      241 tcctttccgc cgccccccgc cgcagcccgg ctacagcccc tcttcctccg ggggggctcc
      301 tcccgcggcc ggagaggctc gggcgacagc agcaccagca ccagcaccag ccgcgggggg
      361 tgcggcggca gacgcggcgg aggcggcggc tccccgagca gcagcacagg cgcggagcga
      421 gaggacgacg acgagagcat tagcatcagc aagccactgg tgcccgccgc cgccgcgctc
      481 cccgggcccc cagctcaggg gggcgtccca gtctccgcca ccgcgcccgc cgccgcctcc
      541 tccacttcca cgcccacctc ttcctgcagc atgaccgccg cggacttcgg cgcgggcgcc
      601 gcggccggca ccgtcggggg ccccgggagc cgctcggcgg tgggcgcagg cggcaccggg
      661 accggcggcg ccgcctcctg ctgctcgtgc tgctgttgct gctgcggccg ccccactcgc
      721 tccggccgta ggggtcggcg ccggggctgc tcgccaagcc ccggctgccg ctggggctac
      781 caggcgctgt ctgtggtgct gctgctggcg cagggcggtc tgctggacct gtacctcatt
      841 gcagtcactg acctgtactg gtgctcttgg atcgccaccg acctcgtggt ggtggtgggc
      901 tgggccatct tcttcgccaa gaacagccgg ggccgtcggg gcggcccagc gaacagcatg
      961 cacaaccacc accagctcca ccaccactcg gctccgcctc tgcacctatc cgcagcggcg
     1021 tcggcggggg ccggggccaa ggctcgcggg ggccgaggag gttctggagg ctccggagcc
     1081 gggccgggga cgactggggc agcgggcgag ttcgcttttg cgtacctggc ctggctcatc
     1141 tactccatcg ctttcacccc taaggtggtg ctcatcctgg gcacatccat cctggacctc
     1201 atcgagctgc gcgcgccctt tggcaccacg ggctttcgcc ttaccatggc gctgtccgtg
     1261 ccgctgctct acagcctagt gcgtgccatt agcgaggcgg gcgcgccccc gggctcggcg
     1321 ggtcccctgc tcctgcagcc acagcagcat cgcgccgcgg gctgcttcct gggcacgtgt
     1381 ctggacctgc tggacagctt tacactggtg gagctgatgc tggacggccg cgtgccgctt
     1441 ccggcgcacc tgcgctacct gctcatcgcc gtctacttcc tcactcttgc ctccccagtg
     1501 ctctggctgt acgagctgaa cactgccaca gcagctccgt cctggggtca gacctccggg
     1561 cccggaagct gcagccgcct tttacgtttg ctgggcggct gcctggtgga cgtgcccttg
     1621 ctggcgctgc gcagcctcct ggtcgtgagc taccaacagc cgctgtccat ctttatgctc
     1681 aagaatctct ttttccttgg ctgccgtggc ctggaggcct tggagggctg ctgggaccgg
     1741 gggagttggg tatccccaag tcgggccaga agcagctatg gtgctcctcc ctctgcccct
     1801 cccccacctc caccaccacc acctcaggga ggctcccagc ggggccactt ggaaaatgaa
     1861 gggggccctc atggctatgt caacactcta gctgttgcct ctcagaattg aagcagtgaa
     1921 gggcaggggc cctgttcttg gctttagggt ttccgccccc ccttggctgt gtttggaggt
     1981 aagtgttgat aaggcagaag gccagtggat tcttctgcac cccgtgggta gagactgctt
     2041 ggagggagac cagcaatata ccgtgaggaa gaagggccca tgttcaccgc ggtcttcttc
     2101 cctgtcctga catacaaggg attggataca cgtgccaccg gcttttctcg ccttcatcct
     2161 gattcctatt cctgtagggg agaatggagg aaaggggttc aggcagggat agtgagcatt
     2221 ggggtgtgtg tgtgtgtgta gtgtattttc tgggtgtcag tcccatgccc cttgcagtgg
     2281 gaaggagatc tagagaggcc ttgcttcaca acacacctac caccatgctt tcctacctgg
     2341 actgatgacc accgtcccct cgatggagtt gttgctcggt tgctgtactc caagggagaa
     2401 gctcgcccag ggtcttcctc cctcctgccc ctctctgctc agcctgggga ggagcaggtc
     2461 tctatggaag gaccaaacac ccaccctttc ttgggtgagc acgcactcta cctctgtgct
     2521 tcgatttcca gtgcatcaca cactgatgct gcttgaaaaa aaaaatcaaa cactcagaag
     2581 ttgcattcaa cagggccact ggatcccctt gggattcggt gccagatatt acagggtctg
     2641 tggagtacca gccattggct tgctctccct ttgttcctcc ctctgcacca gaataattat
     2701 ccttcctgtg ttggtgccag ccgggttgga attgggttca gagcaactgc tttagcgtgt
     2761 tcaaatgtat gtgaggtcag gcctcttagg gacccgggca gtagcaccgg tgcctttaga
     2821 aaacttggca cagagcagag agggtgtgtg acctttcacc tctcctctgc ttcagatctc
     2881 ttcagggaga aggcacactg cagagccctc ctgcctagcc ttccccagca gggttccctg
     2941 gagaggctgt ccttaggatt gtccttcaag ggaagtcagg gttggctcct gcaggcttca
     3001 tgagggatgt catccttggg gtctttaagg caggatatgt attctgaggg caatcaaggt
     3061 tcagaaggca caaggagcca ggctggggta tactcacccc aacaaggagc caggctgggg
     3121 tatactcacc ccaacaagga gccaggctgg ggtatactca ccccaacaag gagccaggct
     3181 ggggtatact ctccccgaca atggggttgg gggcgggagg gttcctctcc ttctattttg
     3241 ggagttttat gtggcgtaat gaacctagac aagagaccag aaaaaaatga tctgtagttc
     3301 tgtctgttac ctgctaggtt tgaacaccgt accattttac tgtttaggcc tctggggtag
     3361 tgttctttga gttggggctt gaagagtctg gtcataacgc tgccgtaaag gtagtcagag
     3421 aggaactgtc caggtggact tgaggagggc tctgcttctg taccatgtct ggccttaggc
     3481 tgggagaact gagggaggtt tgccagctag ggtgggggac aggcatcgca gggtcctcta
     3541 aagccaagca caggggaagg cccagagtgc caagtcactg actagtaact tagcagccag
     3601 gcccatgtcc ctcattccct ttgcctctgt taggaccttc tgagaaccaa gggctgtatg
     3661 gggcccctct tattcagctg cccagggcta tgggctgagg gtatctatgt ggacagaagt
     3721 gtggacggct gagctggaac actcgtgggc ctgcccagct aatgtgggcc gtgtggaggg
     3781 tgtttacagt ctgcgctcta tactcctgct ctctcgactt cggccgacta gctgcttttc
     3841 acagtaagcc tgccttttct cctcaacctg gctgactgtc cttctgactg gactcatggt
     3901 cctgggccta aggcccgggc gggggctgca gctgctccca gtgctctgac tgtgtccccc
     3961 agcttcgctg tgtttcttgc tacctaattt caatgactgt gaaaagaaat gatctctgag
     4021 ccatggccgg ctctggctgg cccccaaccc accctctttc tactgtttgg atagctgtcc
     4081 ctctgctgtg gaaatgctgt ctgctgctga gagactgcca ctggatttag gacaggaagg
     4141 ctgacatttc cttggtacat caagagacat ggtcacatgg ccacgtgtga gtgaggccag
     4201 ggttgctgag ggcctagtga gggcccagca caggtcctgt acatcatcta caagtcttct
     4261 gtgagtgtct gactcagggc tggttccttc ctctgggcta tttattttgg ctcttttcag
     4321 tcattcccct gttccattca cacatgacct actaggaagg cctctttgtt tcatctcttg
     4381 ctttctaggg tatctgtaga cagggatcag acttgagatg tccccaaagt gtcatgacca
     4441 gaatagtaca ctgtcctgag tcccgaagaa tggactatgg aaggaaggct aggctcagaa
     4501 tttagcctcg tgggctccta gcctctgagc atagaggctg agggcctggt acctgagttt
     4561 taaaaacaag ttaattactt tgtagtactg aggtttaaac ctagggcctc aggcacgctt
     4621 gacgaatgct tgtcagcctg ccgctcaaca tccccaacac caagtcttat tcagtctgtg
     4681 ctctctctaa agacttgcat cccatctttt aaacatttct tttagtgggt gtctcactgt
     4741 gttcccaggg ctggcttaga atttgggggt ttaggagacc ctctttagcc tctcaaggaa
     4801 acaggagtgc cctgtgtcat ccaaccaaga ctgtgcctgt taaccatgct ctgggaagcc
     4861 ggccgatgtg ggggcccaga gctgggacag caagcccgga agaggcagag aagtggcacc
     4921 tcgctagcat tcatcacatt cccccccccc ttttaaaaat aaaaccagac tctgttctga
     4981 aaataaaaac ttgagacttg tgacaagc
//
