LOCUS       NM_172541               1278 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus transmembrane protein 120A (Tmem120a), mRNA.
ACCESSION   NM_172541
VERSION     NM_172541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Del Rosario,J.S., Gabrielle,M., Yudin,Y. and Rohacs,T.
  TITLE     TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels
  JOURNAL   J Gen Physiol 154 (8) (2022)
   PUBMED   35819364
  REMARK    GeneRIF: TMEM120A/TACAN inhibits mechanically activated PIEZO2
            channels.
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Czapiewski,R., Batrakou,D.G., de Las Heras,J.I., Carter,R.N.,
            Sivakumar,A., Sliwinska,M., Dixon,C.R., Webb,S., Lattanzi,G.,
            Morton,N.M. and Schirmer,E.C.
  TITLE     Genomic loci mispositioning in Tmem120a knockout mice yields latent
            lipodystrophy
  JOURNAL   Nat Commun 13 (1), 321 (2022)
   PUBMED   35027552
  REMARK    GeneRIF: Genomic loci mispositioning in Tmem120a knockout mice
            yields latent lipodystrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Li,S., Qian,N., Jiang,C., Zu,W., Liang,A., Li,M., Elledge,S.J. and
            Tan,X.
  TITLE     Gain-of-function genetic screening identifies the antiviral
            function of TMEM120A via STING activation
  JOURNAL   Nat Commun 13 (1), 105 (2022)
   PUBMED   35013224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Rong,Y., Jiang,J., Gao,Y., Guo,J., Song,D., Liu,W., Zhang,M.,
            Zhao,Y., Xiao,B. and Liu,Z.
  TITLE     TMEM120A contains a specific coenzyme A-binding site and might not
            mediate poking- or stretch-induced channel activities in cells
  JOURNAL   Elife 10, e71474 (2021)
   PUBMED   34409941
  REMARK    GeneRIF: TMEM120A contains a specific coenzyme A-binding site and
            might not mediate poking- or stretch-induced channel activities in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Niu,Y., Tao,X., Vaisey,G., Olinares,P.D.B., Alwaseem,H., Chait,B.T.
            and MacKinnon,R.
  TITLE     Analysis of the mechanosensor channel functionality of TACAN
  JOURNAL   Elife 10, e71188 (2021)
   PUBMED   34374644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Beaulieu-Laroche,L., Christin,M., Donoghue,A., Agosti,F.,
            Yousefpour,N., Petitjean,H., Davidova,A., Stanton,C., Khan,U.,
            Dietz,C., Faure,E., Fatima,T., MacPherson,A.,
            Mouchbahani-Constance,S., Bisson,D.G., Haglund,L., Ouellet,J.A.,
            Stone,L.S., Samson,J., Smith,M.J., Ask,K., Ribeiro-da-Silva,A.,
            Blunck,R., Poole,K., Bourinet,E. and Sharif-Naeini,R.
  TITLE     TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
  JOURNAL   Cell 180 (5), 956-967 (2020)
   PUBMED   32084332
  REMARK    GeneRIF: TACAN Is an Ion Channel Involved in Sensing Mechanical
            Pain.
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Batrakou,D.G., de Las Heras,J.I., Czapiewski,R., Mouras,R. and
            Schirmer,E.C.
  TITLE     TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important
            for Adipocyte Differentiation
  JOURNAL   PLoS One 10 (5), e0127712 (2015)
   PUBMED   26024229
  REMARK    GeneRIF: it is possible that the TMEM120A and B fat-specific
            nuclear envelope transmembrane proteins may play a contributory
            role in the tissue-specific pathology of this disorder or in the
            wider problem of obesity.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Malik,P., Korfali,N., Srsen,V., Lazou,V., Batrakou,D.G.,
            Zuleger,N., Kavanagh,D.M., Wilkie,G.S., Goldberg,M.W. and
            Schirmer,E.C.
  TITLE     Cell-specific and lamin-dependent targeting of novel transmembrane
            proteins in the nuclear envelope
  JOURNAL   Cell Mol Life Sci 67 (8), 1353-1369 (2010)
   PUBMED   20091084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK028119.1.
            
            On Apr 6, 2007 this sequence version replaced NM_172541.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028119.1, BC046757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1278              AK028119.1         2-1279
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.38 cM"
     gene            1..1278
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /note="transmembrane protein 120A"
                     /db_xref="GeneID:215210"
                     /db_xref="MGI:MGI:2686991"
     exon            1..125
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1076
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /note="transmembrane protein induced by tumor necrosis
                     factor alpha; ion channel TACAN"
                     /codon_start=1
                     /product="transmembrane protein 120A"
                     /protein_id="NP_766129.1"
                     /db_xref="CCDS:CCDS19744.1"
                     /db_xref="GeneID:215210"
                     /db_xref="MGI:MGI:2686991"
                     /translation="MQSPPPDPLGDCLRNWEDLQQDFQGIQETHRLYRLKLEELTKLQ
                     ANCTNSITRQKKRLQELALVLKKCRPSLPSESMEAAQELENQMKERQGLFFDMEAYLP
                     KKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILIVISFTCRFLLNSRVT
                     DAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQK
                     FRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLL
                     PFLFFGHFWQLFNALTLFNLARDPECKEWQVLMCGFPFLLLFLGNFFTTLRVVHQKFH
                     SQQHGNKKD"
     exon            126..244
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            245..361
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            362..421
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            422..517
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            518..607
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            608..673
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            674..735
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            736..828
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            829..893
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            894..962
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1278
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1258..1263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /note="putative"
     polyA_site      1278
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /note="putative"
ORIGIN      
        1 ctccccactc gcggctctcc gcggccagtg gcgtggacaa agacatgcag tccccgcccc
       61 cggacccgct gggcgactgc ctgcgcaact gggaggatct gcagcaggac ttccaaggta
      121 tccaggaaac acatcgcctg tatcgcctca agctagagga gctgaccaaa ctccaggcca
      181 actgtacaaa ctccatcaca cggcagaaga agcggctcca ggagctggcc ttggtgctga
      241 aaaaatgcag accctctctc ccatccgagt ccatggaggc tgcacaggag ctggaaaacc
      301 agatgaaaga gcgccaaggc ctcttcttcg acatggaagc ctatctgcct aagaagaacg
      361 ggttgtacct gagtctggtt ctggggaatg tcaacgtgac acttctgagc aagcaggcta
      421 agttcgctta caaagacgag tacgagaaat tcaagctcta cctcaccatc atcctcatcg
      481 tcatctcctt cacctgccgc ttcctgctca actccagggt gacggacgca gccttcaact
      541 tcctgctggt ctggtattat tgcacgctga ccatccggga gagcatcctc atcaacaatg
      601 gttccaggat caaaggctgg tgggttttcc atcattatgt gtccacattc ctgtcaggag
      661 tcatgctgac ctggccagat ggactcatgt accagaagtt ccggaaccag ttcctgtctt
      721 tctccatgta ccagagcttt gtgcaattcc tgcagtatta ctatcagagc gggtgcctgt
      781 accgcctgcg agccctgggc gagcgccata cgatggatct caccgtagag ggctttcagt
      841 cttggatgtg gagaggcctc accttcctgc ttccgttcct cttctttgga cacttctggc
      901 aactcttcaa tgcgctgaca ttgtttaact tggcccggga cccggagtgc aaggagtggc
      961 aggtgctcat gtgcggcttc cccttcctcc tcctcttcct cggcaatttc ttcaccaccc
     1021 tgcgagtggt gcatcagaag ttccacagcc agcagcacgg gaacaagaag gactgagcta
     1081 gatctgatgc cagccccaaa ggggcttttt gacctgtgtg ccaggtgggg cagcaggttg
     1141 gggttacccc ttgtgtaggg ggttcccttc tgtgccccct gagctttgtg ggctctgtgg
     1201 gccctgagga aggcctgggc ctggagccca gcttgcagga ttcgggctct aggcctcaat
     1261 aaaggaagag aggcatgg
//
