LOCUS       NP_766129                343 aa            linear   ROD 16-FEB-2025
DEFINITION  transmembrane protein 120A [Mus musculus].
ACCESSION   NP_766129
VERSION     NP_766129.1
DBSOURCE    REFSEQ: accession NM_172541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 343)
  AUTHORS   Del Rosario,J.S., Gabrielle,M., Yudin,Y. and Rohacs,T.
  TITLE     TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels
  JOURNAL   J Gen Physiol 154 (8) (2022)
   PUBMED   35819364
  REMARK    GeneRIF: TMEM120A/TACAN inhibits mechanically activated PIEZO2
            channels.
REFERENCE   2  (residues 1 to 343)
  AUTHORS   Czapiewski,R., Batrakou,D.G., de Las Heras,J.I., Carter,R.N.,
            Sivakumar,A., Sliwinska,M., Dixon,C.R., Webb,S., Lattanzi,G.,
            Morton,N.M. and Schirmer,E.C.
  TITLE     Genomic loci mispositioning in Tmem120a knockout mice yields latent
            lipodystrophy
  JOURNAL   Nat Commun 13 (1), 321 (2022)
   PUBMED   35027552
  REMARK    GeneRIF: Genomic loci mispositioning in Tmem120a knockout mice
            yields latent lipodystrophy.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 343)
  AUTHORS   Li,S., Qian,N., Jiang,C., Zu,W., Liang,A., Li,M., Elledge,S.J. and
            Tan,X.
  TITLE     Gain-of-function genetic screening identifies the antiviral
            function of TMEM120A via STING activation
  JOURNAL   Nat Commun 13 (1), 105 (2022)
   PUBMED   35013224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 343)
  AUTHORS   Rong,Y., Jiang,J., Gao,Y., Guo,J., Song,D., Liu,W., Zhang,M.,
            Zhao,Y., Xiao,B. and Liu,Z.
  TITLE     TMEM120A contains a specific coenzyme A-binding site and might not
            mediate poking- or stretch-induced channel activities in cells
  JOURNAL   Elife 10, e71474 (2021)
   PUBMED   34409941
  REMARK    GeneRIF: TMEM120A contains a specific coenzyme A-binding site and
            might not mediate poking- or stretch-induced channel activities in
            cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 343)
  AUTHORS   Niu,Y., Tao,X., Vaisey,G., Olinares,P.D.B., Alwaseem,H., Chait,B.T.
            and MacKinnon,R.
  TITLE     Analysis of the mechanosensor channel functionality of TACAN
  JOURNAL   Elife 10, e71188 (2021)
   PUBMED   34374644
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 343)
  AUTHORS   Beaulieu-Laroche,L., Christin,M., Donoghue,A., Agosti,F.,
            Yousefpour,N., Petitjean,H., Davidova,A., Stanton,C., Khan,U.,
            Dietz,C., Faure,E., Fatima,T., MacPherson,A.,
            Mouchbahani-Constance,S., Bisson,D.G., Haglund,L., Ouellet,J.A.,
            Stone,L.S., Samson,J., Smith,M.J., Ask,K., Ribeiro-da-Silva,A.,
            Blunck,R., Poole,K., Bourinet,E. and Sharif-Naeini,R.
  TITLE     TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
  JOURNAL   Cell 180 (5), 956-967 (2020)
   PUBMED   32084332
  REMARK    GeneRIF: TACAN Is an Ion Channel Involved in Sensing Mechanical
            Pain.
REFERENCE   7  (residues 1 to 343)
  AUTHORS   Batrakou,D.G., de Las Heras,J.I., Czapiewski,R., Mouras,R. and
            Schirmer,E.C.
  TITLE     TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important
            for Adipocyte Differentiation
  JOURNAL   PLoS One 10 (5), e0127712 (2015)
   PUBMED   26024229
  REMARK    GeneRIF: it is possible that the TMEM120A and B fat-specific
            nuclear envelope transmembrane proteins may play a contributory
            role in the tissue-specific pathology of this disorder or in the
            wider problem of obesity.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 343)
  AUTHORS   Malik,P., Korfali,N., Srsen,V., Lazou,V., Batrakou,D.G.,
            Zuleger,N., Kavanagh,D.M., Wilkie,G.S., Goldberg,M.W. and
            Schirmer,E.C.
  TITLE     Cell-specific and lamin-dependent targeting of novel transmembrane
            proteins in the nuclear envelope
  JOURNAL   Cell Mol Life Sci 67 (8), 1353-1369 (2010)
   PUBMED   20091084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK028119.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028119.1, BC046757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.38 cM"
     Protein         1..343
                     /product="transmembrane protein 120A"
                     /note="transmembrane protein induced by tumor necrosis
                     factor alpha; ion channel TACAN"
                     /calculated_mol_wt=40620
     Region          13..336
                     /region_name="TMPIT"
                     /note="TMPIT-like protein; pfam07851"
                     /db_xref="CDD:462288"
     Site            136..156
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     Site            163..183
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     Site            191..211
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     Site            223..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     Site            274..294
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     Site            306..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C1E7.1)"
     CDS             1..343
                     /gene="Tmem120a"
                     /gene_synonym="2010310D06Rik; Tmpit"
                     /coded_by="NM_172541.2:45..1076"
                     /db_xref="CCDS:CCDS19744.1"
                     /db_xref="GeneID:215210"
                     /db_xref="MGI:MGI:2686991"
ORIGIN      
        1 mqspppdplg dclrnwedlq qdfqgiqeth rlyrlkleel tklqanctns itrqkkrlqe
       61 lalvlkkcrp slpsesmeaa qelenqmker qglffdmeay lpkknglyls lvlgnvnvtl
      121 lskqakfayk deyekfklyl tiilivisft crfllnsrvt daafnfllvw yyctltires
      181 ilinngsrik gwwvfhhyvs tflsgvmltw pdglmyqkfr nqflsfsmyq sfvqflqyyy
      241 qsgclyrlra lgerhtmdlt vegfqswmwr gltfllpflf fghfwqlfna ltlfnlardp
      301 eckewqvlmc gfpflllflg nffttlrvvh qkfhsqqhgn kkd
//
