LOCUS       NM_146162               2122 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus transmembrane protein 119 (Tmem119), transcript
            variant 1, mRNA.
ACCESSION   NM_146162
VERSION     NM_146162.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Feichtenbiner,A.B., Sytsma,K., O'Boyle,R.P., Mittenzwei,R.,
            Maioli,H., Scherpelz,K.P., Child,D.D., Li,N., Ariza Torres,J.,
            Keene,L., Kirkland,A., Howard,K., Latimer,C., Keene,C.D., Ransom,C.
            and Nolan,A.L.
  TITLE     Satellite microglia: marker of traumatic brain injury and regulator
            of neuronal excitability
  JOURNAL   J Neuroinflammation 22 (1), 9 (2025)
   PUBMED   39819341
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Duffy,H.B.D., Byrnes,C., Zhu,H., Tuymetova,G., Lee,Y.T., Platt,F.M.
            and Proia,R.L.
  TITLE     Deletion of Gba in neurons, but not microglia, causes
            neurodegeneration in a Gaucher mouse model
  JOURNAL   JCI Insight 9 (21), e179126 (2024)
   PUBMED   39312723
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Matsumura,D., Kawao,N., Yamada,A., Okumoto,K., Ohira,T.,
            Mizukami,Y., Goto,K. and Kaji,H.
  TITLE     Tmem119 deficiency delays bone repair in mice
  JOURNAL   Bone 186, 117177 (2024)
   PUBMED   38942344
  REMARK    GeneRIF: Tmem119 deficiency delays bone repair in mice.
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Rosmus,D.D., Koch,J., Hausmann,A., Chiot,A., Arnhold,F., Masuda,T.,
            Kierdorf,K., Hansen,S.M., Kuhrt,H., Froba,J., Wolf,J., Boneva,S.,
            Gericke,M., Ajami,B., Prinz,M., Lange,C. and Wieghofer,P.
  TITLE     Redefining the ontogeny of hyalocytes as yolk sac-derived
            tissue-resident macrophages of the vitreous body
  JOURNAL   J Neuroinflammation 21 (1), 168 (2024)
   PUBMED   38961498
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Bedolla,A., Wegman,E., Weed,M., Stevens,M.K., Ware,K., Paranjpe,A.,
            Alkhimovitch,A., Ifergan,I., Taranov,A., Peter,J.D.,
            Gonzalez,R.M.S., Robinson,J.E., McClain,L., Roskin,K.M., Greig,N.H.
            and Luo,Y.
  TITLE     Adult microglial TGFbeta1 is required for microglia homeostasis via
            an autocrine mechanism to maintain cognitive function in mice
  JOURNAL   Nat Commun 15 (1), 5306 (2024)
   PUBMED   38906887
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Mizuhashi,K., Kanamoto,T., Ito,M., Moriishi,T., Muranishi,Y.,
            Omori,Y., Terada,K., Komori,T. and Furukawa,T.
  TITLE     OBIF, an osteoblast induction factor, plays an essential role in
            bone formation in association with osteoblastogenesis
  JOURNAL   Dev Growth Differ 54 (4), 474-480 (2012)
   PUBMED   22416756
  REMARK    GeneRIF: Obif plays an essential role in bone formation through
            regulating osteoblastogenesis.
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Hisa,I., Inoue,Y., Hendy,G.N., Canaff,L., Kitazawa,R., Kitazawa,S.,
            Komori,T., Sugimoto,T., Seino,S. and Kaji,H.
  TITLE     Parathyroid hormone-responsive Smad3-related factor, Tmem119,
            promotes osteoblast differentiation and interacts with the bone
            morphogenetic protein-Runx2 pathway
  JOURNAL   J Biol Chem 286 (11), 9787-9796 (2011)
   PUBMED   21239498
  REMARK    GeneRIF: Parathyroid hormone-responsive Smad3-related factor,
            Tmem119, promotes osteoblast differentiation and interacts with the
            bone morphogenetic protein-Runx2 pathway.
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Kanamoto,T., Mizuhashi,K., Terada,K., Minami,T., Yoshikawa,H. and
            Furukawa,T.
  TITLE     Isolation and characterization of a novel plasma membrane protein,
            osteoblast induction factor (obif), associated with osteoblast
            differentiation
  JOURNAL   BMC Dev Biol 9, 70 (2009)
   PUBMED   20025746
  REMARK    GeneRIF: Study identifies a novel gene, obif (osteoblast induction
            factor), encoding a transmembrane protein that is predominantly
            expressed in osteoblasts.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2122)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132939.23.
            
            On Jan 31, 2019 this sequence version replaced NM_146162.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025600.1, AK170712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC132939.23        15719-15815
            98-2122             AC132939.23        20362-22386
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.55 cM"
     gene            1..2122
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /note="transmembrane protein 119"
                     /db_xref="GeneID:231633"
                     /db_xref="MGI:MGI:2385228"
     exon            1..97
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /inference="alignment:Splign:2.1.0"
     exon            98..2122
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..955
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /note="osteoblast induction factor"
                     /codon_start=1
                     /product="transmembrane protein 119 precursor"
                     /protein_id="NP_666274.1"
                     /db_xref="CCDS:CCDS19554.1"
                     /db_xref="GeneID:231633"
                     /db_xref="MGI:MGI:2385228"
                     /translation="MVPWFLLSLLLLARPVPGVAYSVSLPASFLEDVAGSGEAEGSSA
                     SSPSLPPPGTPAFSPTPERPQPTALDGPVPPTNLLEGIMDFFRQYVMLIAVVGSLTFL
                     IMFIVCAALITRQKHKATAYYPSSFPEKKYVDQRDRAGGPRTFSEVPDRAPDSRHEEG
                     LDTSHQLQADILAATQNLRSPARALPGNGEGAKPVKGGSEEEEEEVLSGQEEAQEAPV
                     CGVTEEKLGVPEESVSAEAEGVPATSEGQGEAEGSFSLAQESQGATGPPESPCACNRV
                     SPSV"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="Tmem119"
                     /gene_synonym="obif"
                     /note="major polyA site"
ORIGIN      
        1 agagcagctg gcggcagacg gcaggcagac agtcagaccg tctagcgggc ctggcttgcc
       61 tacctggcag ctgcacccgg tccttcaccc agagctggtt ccatagctca acatggtccc
      121 ctggttcctc ctgtctctgc tgctacttgc gaggcctgtg cctggggtgg cctactctgt
      181 gtcactcccg gcctccttcc tggaggatgt agccggcagc ggggaagctg agggttcttc
      241 agcctcttcc ccgagcctgc cgccgcctgg gactccagcc ttcagtccca caccggagag
      301 accccagccc acagctctgg acggccccgt gccacccacc aacctcctgg aagggatcat
      361 ggatttcttc cggcagtacg tgatgctcat cgcggtggtg ggctcgctga ccttcctcat
      421 catgttcata gtctgcgccg ccctcatcac gcgccagaag cacaaggcca cagcctacta
      481 cccatcctcg ttccctgaaa agaagtatgt ggaccagaga gaccgggctg ggggaccccg
      541 taccttcagc gaggtccctg acagggcacc tgacagccgg catgaagaag gcctggacac
      601 ctcccatcag ctccaggctg acattctggc tgctacccag aacctccggt ctccagctag
      661 agccctgcca ggcaatgggg agggagcaaa gcctgtgaag ggtgggtcgg aggaggagga
      721 ggaagaggtg ctcagcggtc aggaggaggc ccaggaagcc ccagtatgtg gggtcactga
      781 agagaagctg ggggtcccag aggagtcggt ctcagcagag gctgaagggg ttcctgccac
      841 cagtgagggc caaggggaag cagaagggtc tttctcctta gcccaggaat cccagggagc
      901 aactggtcct cctgaaagtc cctgtgcctg caacagagtc tcccccagtg tctaacaggc
      961 cccagaactg ctgggacccg aatgttgggt ccttgagggt cacctctttg gtcaagaaag
     1021 gcattcagct ctaactgctc cttgatacca cgtggcttgg ccattgctgg tgccaaggct
     1081 gaccccgaac tggcagagcc gatgccctct ggtgcacccc aggaaacatc tccccaagtt
     1141 ccagcgccct taatgactct tgccaccctg ggggcttcac cctaacgcac cacttctctg
     1201 gaaggggaag gccagacaca tgccagttgg ggctgcatga ggcagtcctc agagcagaag
     1261 gggaccaggc cagaggccac ctgtgacggg gcaaactgca tctcggctgt ggagaccaga
     1321 ggggctgtta gatttggaag acatcaatga ctgggcctgc ggcgcagccc gtgtctggta
     1381 ataccaggga cggcagaggc gtttgcatct tcccatcacc tgcaatgtcg ctgtcactct
     1441 gcccctgttc agtggacttg attagttagg aaacttctgg aaggggcccc ctactttata
     1501 tcacagagtt tgccctagac accccgtgga aacacaaact caaaatcaag tggctttagg
     1561 agccgctgtg cccctccaca agctgacatg gctactctaa gggttcctgc tgggctggct
     1621 ttgctacgct ttcctcaagc tgctttctta ttaccaggat gcctcacagc tacaaagtcc
     1681 aatctcacag cacccgcact ggaaaatact gttctccatt tttttccaag gcaccctgct
     1741 ttatgattgg ctcagagttg gaatatggga tgcagggcgt ctggctctct caagtgtcaa
     1801 gcaaccctgg cttccgcatg tggggcgagg ggagtgagca gaactcttct ctgtcagtcc
     1861 acgaagtaga ctagaagcca acgggtgcct gggggcaact gacggtctgg attctgacgc
     1921 ccagcctgga gcaggggcct ggcccatcct atgctcacac agtggtctgg cagcctgagc
     1981 ccacacaact cctcagtcct tgacaatgct taggctctgt tctgagggac tccccacacc
     2041 tccattcagg gctccccgag tcctcagctc ttcggatgtg gatatatgac acactagcat
     2101 aataaatctt gatctggctt ga
//
