LOCUS       NM_178789               2781 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protein 117 (Tmem117), mRNA.
ACCESSION   NM_178789
VERSION     NM_178789.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Yang,Y., Wang,X., Yan,P., Wang,D., Luo,T., Zhou,Y., Chen,S.,
            Liu,Q., Hou,J. and Wang,P.
  TITLE     Transmembrane protein 117 knockdown protects against
            angiotensin-II-induced cardiac hypertrophy
  JOURNAL   Hypertens Res 46 (10), 2326-2339 (2023)
   PUBMED   37488300
  REMARK    GeneRIF: Transmembrane protein 117 knockdown protects against
            angiotensin-II-induced cardiac hypertrophy.
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Gaspari,S., Labouebe,G., Picard,A., Berney,X., Rodriguez
            Sanchez-Archidona,A. and Thorens,B.
  TITLE     Tmem117 in AVP neurons regulates the counterregulatory response to
            hypoglycemia
  JOURNAL   EMBO Rep 24 (8), e57344 (2023)
   PUBMED   37314252
  REMARK    GeneRIF: Tmem117 in AVP neurons regulates the counterregulatory
            response to hypoglycemia.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC147160.2,
            AC158918.7, AC118683.10 and AC102905.9.
            
            On May 2, 2007 this sequence version replaced NM_178789.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047437.1, AK048597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC147160.2         128369-128486
            119-421             AC147160.2         137245-137547
            422-554             AC158918.7         42766-42898
            555-654             AC158918.7         207285-207384
            655-752             AC118683.10        105533-105630       c
            753-912             AC118683.10        25951-26110         c
            913-1042            AC102905.9         74065-74194
            1043-2781           AC102905.9         94020-95758
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.65 cM"
     gene            1..2781
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /note="transmembrane protein 117"
                     /db_xref="GeneID:320709"
                     /db_xref="MGI:MGI:2444580"
     exon            1..118
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..421
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1689
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /codon_start=1
                     /product="transmembrane protein 117"
                     /protein_id="NP_848904.1"
                     /db_xref="CCDS:CCDS27774.1"
                     /db_xref="GeneID:320709"
                     /db_xref="MGI:MGI:2444580"
                     /translation="MGKDFRYYFQHPWSRMIVAYLVIFFNFLIFAEDPVSHSQTEANV
                     IVVGNCFSFVTNKYPRGVGWRILKVLLWLLAILIGLIAGKFLFHQRLFGQLLRLKMFR
                     EDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYLITDYMGIRNESFMKLAAVGT
                     WMGDFVTAWMVTDMMLQDKPYPDWGKSARAFWKKGNVRIILFWTVLFTLTSVVVLVIT
                     TDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHT
                     PHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFLVLILDLNMWKNQIFYKPHEYGQYI
                     GPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPQTNKTYVEGDMFLHSRFIGASLDV
                     KCLAFVPSLIAFVWFGFFIWFFGRFLKNEQGMENQDKTYTRMKRKSPSEHSKDMGITR
                     ENTQVSVEDPLNDPALVCIRSDFNEIVYKSSHLTSENLSLHLKESTSEVEAEQEPAAS
                     QRMRTN"
     exon            422..554
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..654
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            655..752
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..912
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1042
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..2781
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccagcgta ggcggcggcg tgggccgcgg tatttatagc caggtgacag cagcgcgccg
       61 cggcccgtgt cgccgctcgt cctgcgtccg ccgcggtggc cgagccgcgc gccctccggt
      121 caagcagcac caaaggcttg aaggatgggt aaagacttcc gctactattt ccagcatcct
      181 tggtctcgca tgatcgtggc ttacctggtc atcttcttta acttcttgat attcgctgag
      241 gacccagtct ctcacagcca aacagaagct aatgttattg ttgttggaaa ctgtttttca
      301 tttgtaacaa ataaataccc tagaggagtt ggctggagga ttttgaaggt gcttctatgg
      361 ctactggcca ttctcatagg actgattgct ggcaagttcc tcttccatca gcgtttattt
      421 ggccagttgc tccggttaaa aatgttccgg gaagaccatg ggtcgtggat gacgatgttc
      481 ttcagcacaa ttctctttct cttcatcttc tctcacatct ataacaccat ccttctgatg
      541 gacgggaaca tgggagctta tctcatcact gactatatgg gcatccgcaa tgaaagtttc
      601 atgaaactag ctgctgtggg gacctggatg ggggactttg tcacagcttg gatggtaact
      661 gatatgatgc ttcaagacaa gccctaccct gactggggga aatccgcaag agctttctgg
      721 aagaaaggca acgtgaggat cattttattc tggaccgtcc tcttcaccct gacttccgtg
      781 gtggtgcttg tcatcacgac cgactggatc agctgggaca aactgaaccg tgggtttttg
      841 cccagtgatg aggtctcccg agcctttctt gcttctttca tcttggtctt tgacctcctt
      901 attgtgatgc aggactggga attcccacac ttcatgggcg acgttgatgt gaatctcccc
      961 gggttgcaca cgcctcacat gcagttcaag attcccttct tccagaagat cttcaaggag
     1021 gaataccgca ttcacataac aggtaaatgg tttaactacg gaattatctt tctcgtcttg
     1081 attttggacc tgaatatgtg gaagaaccag atattttaca aacctcatga atatggacag
     1141 tatattggcc cagggcagaa gatatacaca gtgaaagact ctgaaagttt aaaggattta
     1201 aatagaacca agctatcctg ggaatggcgg tccaatcaca ctaatcctca gactaataaa
     1261 acctacgttg aaggtgacat gttcttacac agcaggttca taggggctag cctagatgtc
     1321 aagtgtctgg cttttgttcc aagtttgata gcttttgtgt ggtttggatt cttcatttgg
     1381 ttctttggac ggtttctgaa aaatgagcaa gggatggaga atcaagataa aacttatact
     1441 cgcatgaaaa ggaaatcccc ctcggaacac agcaaagata tgggaatcac ccgagaaaac
     1501 acccaggtct ctgtggaaga tcctctgaat gaccctgcct tggtttgtat caggtctgac
     1561 tttaacgaga tagtctacaa gtcctcccat ctgacttcag aaaacttgag cttacatctg
     1621 aaggaatcta ccagtgaggt ggaggctgag caagagccgg cagcctctca aaggatgagg
     1681 acgaactaga atctcttaga cggagatagc acaaagagca accttgagtg taactttaaa
     1741 accgtagtct ttcattttgt aaatgtcagg tttacatagc gttaggtaaa gaaatacaaa
     1801 ctatgccaca acggtgctca acatgctttt tctagactca ttgttttcta tttgtattat
     1861 gatacacgtg cctattgtat gtttgtttaa tggtcctcta gagattgctt ttcccaaccg
     1921 cacaagctat ttactgactt tacagcaagg tagattagcc gattacccat gtatctgatg
     1981 tccaaccata gcggtgcctt gagacattaa actgtttttt aactgtacca gacatgaagt
     2041 gtagaatggt tctccagtct atttcacatg ggattttttt ttttatacaa ttattttgac
     2101 ttacacttga tgtctgagca gaaaacaaga cagagctgat ttgtggttgt agaaagttct
     2161 cttggttcac tgtttagcag tgaagtgact ttgatgcggg actgcagaga agcatagaga
     2221 ttgccttttt aaattttatt ggctggcaac cgaatataaa tataaatgta aaatccagtc
     2281 agcggagggc tgcaatgcac catgggtcac tgctcacgaa atgtgacttt ctccaaccac
     2341 taattgcaac tagatgataa tacctaatta tgttttccta attaaagtta aattgctgcc
     2401 tgattaatag tcttgccctt ttcctttggg aacaaaggtt aagagaaaca gttgggtgag
     2461 ctctcaaatg tattggcatt tccacaatgt cctggaccac caaggaattg aagtcgtaat
     2521 catgtgaagc cggcacagcc cactgtctac aatattgtac attttttgct gtaaatacgg
     2581 ttctggaccg tgaaaataga aaaccttacg gccatgttga ccaagggaat tctgaaatca
     2641 ttcaccgaaa cctcatgtgg tagaaaatgc tgtacaaggg tctctttaat gtcttctgtg
     2701 tatgtgcatt tcttttctgt ttgggtttct ttttttttaa agatgtaaac atcgcacctt
     2761 aataaataag aattatatgc c
//
