LOCUS       NM_001161627            1364 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 116 (Tmem116), transcript
            variant 1, mRNA.
ACCESSION   NM_001161627
VERSION     NM_001161627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Zhang,S., Dai,H., Li,W., Wang,R., Wu,H., Shen,M., Hu,Y., Xie,L. and
            Xing,Y.
  TITLE     TMEM116 is required for lung cancer cell motility and metastasis
            through PDK1 signaling pathway
  JOURNAL   Cell Death Dis 12 (12), 1086 (2021)
   PUBMED   34789718
  REMARK    GeneRIF: TMEM116 is required for lung cancer cell motility and
            metastasis through PDK1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK127968.1, AK021099.1 and AC129215.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.81641.1,
                                           SRR17784645.135978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               CK127968.1         1-749
            750-1357            AK021099.1         689-1296
            1358-1364           AC129215.3         128562-128568
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.81 cM"
     gene            1..1364
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /note="transmembrane protein 116"
                     /db_xref="GeneID:77462"
                     /db_xref="MGI:MGI:1924712"
     exon            1..90
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            91..137
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            138..201
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            202..333
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..438
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            439..488
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..572
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..711
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            712..856
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            857..930
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1364
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1364
                     /gene="Tmem116"
                     /gene_synonym="4930406A18Rik; 4930513P12Rik;
                     C030022K24Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaagggcct gggcttggag ggtagcagga actgaagtct ttatggcctt cccactggag
       61 accagccgcc tggaaggcag atgggagcct ctttttcctg caatacagtg gatacagttt
      121 gctgtggcta ctctgagtgt tataggctcc agttcactcc tcacctacat cgcgttccag
      181 agcccacaga agtctgcaga gataaagcca ctcttgtatc tgagcttctc tgacctgctc
      241 ctgggaattt gctggctcgt aaaggcactt ctctatggaa ctgcagcagc ccacaaggac
      301 agcatctgct ataacctaca gaccgtgggg gagattttct accttgcctc actcctctac
      361 accgtcagct acatctggtg tctgtactcg gagctgagga ggaagagcgg ccagagtgag
      421 aggagcacgg ttgcccaggt gacagattat gtttgccaag gtggtcacat attgttcctt
      481 ttgtcaagcc tgatacctcc gctgctgatg acgcctgtgt tccttttggg caatgtcaat
      541 gaatgtttcc acaacttcag tgagagccac aggtgtatcc taatgcactc accgccatca
      601 gccacgcctg agcccctgcc ttccaccaat acatctgtct gcagcacact ctatttttat
      661 ggtgtcacca ttttcctggc cagctttttc ttcagcttcc tcaccatcat ggtcttactc
      721 gtccatgccc agatgttata taagaagttt gtgaagtcga cgggccttct ggagagtgag
      781 cagtgggcag tgattcacac tgtgggccag cgagtgcgtt tcttcccagt ggcctttgtg
      841 tgctgctggg gtccagctgt caccctgctg atcatgaagc tgacagagcc tcaggagacc
      901 ttcctgcaca tggccctctc tgtgctccag gctctcacag cagcatccca ggggctgctc
      961 aactgtggca tttatggctg gacacagtgc aagttccagc agataaagcg tgagcctcac
     1021 cgtgacgcag acacgcagac cccactgctg tgctcacaga agagaattta tagtagaagc
     1081 ccaaacctac tggagtctcc tcttgccctt gcttccagct cctccaccgt tctttgagac
     1141 cctagaatgg gaatgtcagg gagtgaatgt ttcacatgag tggactctcc tctggccaaa
     1201 cccgagactg gagagctgaa aggaaatgtg ggctcagggt cagtagcaat tctgggtgaa
     1261 ttcagaagca gctctctaac tgctccttca gagatataca gccgctttcc atctaagaga
     1321 ctcgttactt tgacaagaaa aaataaatct caggttcata tgta
//
