LOCUS       NM_019704               2177 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protein 115 (Tmem115), mRNA.
ACCESSION   NM_019704
VERSION     NM_019704.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2177)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2177)
  AUTHORS   Ong,Y.S., Tran,T.H., Gounko,N.V. and Hong,W.
  TITLE     TMEM115 is an integral membrane protein of the Golgi complex
            involved in retrograde transport
  JOURNAL   J Cell Sci 127 (Pt 13), 2825-2839 (2014)
   PUBMED   24806965
  REMARK    GeneRIF: Results establish that TMEM115 is an integral membrane
            protein of the Golgi stack regulating Golgi-to-ER retrograde
            transport and is likely to be part of the machinery of the COG
            complex.
REFERENCE   3  (bases 1 to 2177)
  AUTHORS   Broglie,P., Matsumoto,K., Akira,S., Brautigan,D.L. and
            Ninomiya-Tsuji,J.
  TITLE     Transforming growth factor beta-activated kinase 1 (TAK1) kinase
            adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling
            by recruiting both an activator and an inhibitor of TAK1 kinase in
            tumor necrosis factor signaling pathway
  JOURNAL   J Biol Chem 285 (4), 2333-2339 (2010)
   PUBMED   19955178
REFERENCE   4  (bases 1 to 2177)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL672219.7.
            
            On Nov 17, 2006 this sequence version replaced NM_019704.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF134238.1, BC019473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1385              AL672219.7         107094-108478
            1386-2177           AL672219.7         111014-111805
FEATURES             Location/Qualifiers
     source          1..2177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.12 cM"
     gene            1..2177
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /note="transmembrane protein 115"
                     /db_xref="GeneID:56395"
                     /db_xref="MGI:MGI:1930765"
     exon            1..1385
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..1587
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /note="placental protein 6; protein PL6 homolog"
                     /codon_start=1
                     /product="transmembrane protein 115"
                     /protein_id="NP_062678.1"
                     /db_xref="CCDS:CCDS23490.1"
                     /db_xref="GeneID:56395"
                     /db_xref="MGI:MGI:1930765"
                     /translation="MQRALPGARQHLGAILASASVVVKALCAVVLFLYLLSFAVDTGC
                     LAVTPGYLFPPNFWIWTLATHGLMEQHVWDVAISLATVVVAGRLLEPLWGALELLIFF
                     SVVNVSVGLLGALAYLLTYMASFNLVYLFTIRIHGALGFLGGVLVALKQTMGDCVVLR
                     VPQVRVSVVPMLLLALLLLLRLATLLQSPALASYGFGLLSSWVYLRFYQRHSRGRGDM
                     ADHFAFATFFPEILQPVVGLLANLVHGLLVKVKICQKTVKRYDVGAPSSITISLPGTD
                     PQDAERRRQLALKALNERLKRVEDQSAWPSMDDDEEEAGAKTDSPLPLEEASTPPGKV
                     TVPESSLITLETAPLL"
     exon            1386..2177
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /note="hexamer: AATAAA"
     polyA_site      2169
                     /gene="Tmem115"
                     /gene_synonym="Pl6; Pp6"
                     /note="major polyA site"
ORIGIN      
        1 gtcggctagg tcccaaggac tccgtatccc agcatgccga gaagccggaa ggcaagcgct
       61 cagagggcgt actgccgcgg ccgccggcgg gggcgcgcag gcgcggcgcc cctgtttgtc
      121 ggccccggag aggggaggag gtaccgtcaa gccaaaaccc tagcccagcc ggagctaaac
      181 gggcttgact tgggccggaa cgaggcacca gttccccgca gatcgcagag tctcagagtg
      241 gatggaggaa gcctagcctt gagattaacg ctagcctggc cgctgggccg acggaacccg
      301 caggcaggcg agcccaagct acccagggcc taacgacagg tccccggcaa gaagactttc
      361 tcctcgcttt ggaactacaa ccggatcaaa ccggaaccag agccttccca cggaacagaa
      421 gccagtgaag tagccgggcc cgggcctccc gtcggggccg aactgggacg aggccccggg
      481 gaggccccta ggccaccttc cacacattcc cttaagccaa cgtccgccag gaagatgcaa
      541 cgcgccctac ctggtgcccg ccaacatctg ggggccatcc tggccagcgc cagcgtggtg
      601 gtgaaggcac tgtgcgccgt ggtactgttt ctctacctgc tttccttcgc tgtggacacg
      661 ggctgcctgg ccgtcacccc aggctacctt ttcccaccca acttctggat ctggaccctg
      721 gccacccacg ggctcatgga acagcacgtg tgggacgtgg ccattagcct ggccacagtg
      781 gttgtggccg ggcgattact ggagcccctc tggggagcct tggagctgct catcttcttc
      841 tcggtggtga atgtgtcagt ggggcttctg ggggccctcg cctacctcct cacctacatg
      901 gcttccttca acttggttta cctgttcact attcgtatcc acggcgccct gggtttccta
      961 ggtggtgttc tggtagccct caagcaaact atgggagact gtgtggttct gcgagtgccc
     1021 caggtccgcg tcagcgtcgt tcccatgctg ttgctggcgt tgctgctact cctccggttg
     1081 gccacgctgc tccagagccc agccctggct tcctacggct ttgggctgct atccagttgg
     1141 gtgtatcttc gcttctatca gcgccatagc cggggccgag gggacatggc tgaccatttt
     1201 gcttttgcca ccttcttccc ggagatcctg caaccggtgg tggggctgct agcgaacttg
     1261 gtgcacggcc tcctggtgaa agtaaagata tgccagaaga cagtgaagcg ctacgatgtg
     1321 ggagcgccgt cgtccatcac tatcagcctc ccaggcacag accctcaaga tgcggagcgc
     1381 agaaggcaac tagccctaaa ggctctcaat gagcggctga agagagtgga ggatcagtca
     1441 gcctggccca gcatggatga tgacgaagag gaagctgggg caaaaacgga cagtcctctg
     1501 cccttagaag aagcttccac gcccccaggg aaggtgaccg tcccggaatc cagtctcatc
     1561 accttggaga cagctcccct actctagacc actttgagtg cagttcttct actcccatgc
     1621 cttcccgatc cgtctcggct actgcagagc actgactgct ctgaggagag ggaagagggt
     1681 ctgctggggg ttcctgtggc cttccgctgt gtctggacaa cactaacaca ggacccttgt
     1741 tgctacctgg ttctgactcc agacaaccac aatgccaggt acggggtctc tgagcagcag
     1801 ccagtgcaga tccccatttg cagtaagatt gtacctcagc ggtacaattc ctcaccaagg
     1861 aagtggctgc agggacactg gtgccacggc tcctgggcca gcccttatgt ctgaaactgg
     1921 ttgccaacag ccccgagcca aggcaaggat ttgtgtttgc caaaaatgtt ctggggaccc
     1981 agccagtgtg ggtctgaaca tccccgccca cccccagact gcattctcat cagggtttct
     2041 tgtgcccttc tgctgtggca gtgacaactg tgcctagccg gggctgccac agctcccagg
     2101 tattttctac aggaccatct gagcgggcag ccaaacctgc ttcacagtat caataaagcg
     2161 gttctttgag gtctggc
//
