LOCUS       NM_173453               1238 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane protein 11 (Tmem11), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173453
VERSION     NM_173453.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1238)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1238)
  AUTHORS   Chen,X.Z., Li,X.M., Xu,S.J., Hu,S., Wang,T., Li,R.F., Liu,C.Y.,
            Xue,J.Q., Zhou,L.Y., Wang,Y.H., Li,P.F. and Wang,K.
  TITLE     TMEM11 regulates cardiomyocyte proliferation and cardiac repair via
            METTL1-mediated m7G methylation of ATF5 mRNA
  JOURNAL   Cell Death Differ 30 (7), 1786-1798 (2023)
   PUBMED   37286744
  REMARK    GeneRIF: TMEM11 regulates cardiomyocyte proliferation and cardiac
            repair via METTL1-mediated m[7]G methylation of ATF5 mRNA.
REFERENCE   3  (bases 1 to 1238)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596215.7, AK077600.1 and AI835409.1.
            
            On Dec 15, 2009 this sequence version replaced NM_173453.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077600.1, BC048514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AL596215.7         7674-7776
            104-1221            AK077600.1         100-1217
            1222-1238           AI835409.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.9 cM"
     gene            1..1238
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /note="transmembrane protein 11"
                     /db_xref="GeneID:216821"
                     /db_xref="MGI:MGI:2144726"
     exon            1..326
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..843
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 11, mitochondrial"
                     /codon_start=1
                     /product="transmembrane protein 11, mitochondrial isoform
                     1"
                     /protein_id="NP_775655.1"
                     /db_xref="CCDS:CCDS24801.1"
                     /db_xref="GeneID:216821"
                     /db_xref="MGI:MGI:2144726"
                     /translation="MAAWGRRRLGPGGGGSRERVSLSATDCYIVHEIYSGENAQDQFE
                     YELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYS
                     HYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRK
                     DDLHRKRLHNTIALAALVYCVKKVYELYAV"
     exon            327..1223
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1223
                     /gene="Tmem11"
                     /gene_synonym="5730466P16Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgttctggga gcccaaggac gtccaggcgg tgggcgcagc gactcgcact ttgcgacttg
       61 aagactcttt cctaaggcgg atcccacccc ctcgccctct tgcgcgcggc agcttacagc
      121 aggcttccgg cgtgaggtat tgtgggcagt gtagtccttc tcgcaacctc ccacctcgtc
      181 cgcgcggctc acgggactac gtttcccttc ggctcccgcg cgccctgagc cgcgtcggct
      241 ccagcccccg acgaaccgag agtctccaag atggccgcgt ggggaaggag gcgtctgggt
      301 ccgggcggcg gcggctcccg agagagggtc agcctctcag ctacagactg ctacattgtg
      361 cacgaaatct acagtgggga gaacgcccag gaccagtttg agtatgagct ggagcaggcg
      421 ctggaagccc agtacaagta cattgtgata gagcccaccc gaattggaga cgagacagca
      481 cgctggatca ccgtaggcaa ttgcctgcac aagacggccg tgttggcagg tactgcctgc
      541 ctcttcaccc cattggcact gcccctggat tactcccact acatctccct gcccgctggt
      601 gtgctgagcc tggcctgctg taccctctat gggatctcct ggcagtttga cccttgctgc
      661 aagtaccagg tggagtatga tgcctataaa ctgtcccgcc tgcctctgca cacgctcacc
      721 tcctccacac cagtggtgct ggttcggaag gacgacctgc acagaaagag actgcacaac
      781 acaatagccc tggctgccct ggtgtactgt gtaaagaagg tttatgagct ctacgccgta
      841 tgactgcagg agagggggac gagaagcaga accacgaggc ccacaggact cagatcccga
      901 cagcagcact gggttttctc tgtgaagcag cagcgcctgg gaaagtgttt ggtttaatac
      961 ttgttatttt tttaagcaaa aataacagat catgggtgtg ccaggggttt cttcagctca
     1021 ttacactaag atgtctattt ccataaccca ggagtggctc ccaggctgtg gaagtctgac
     1081 tgagcagtgg agtatggata ggagccaatg ctactttctg aggggtgtga acttgctgtg
     1141 ggggtgtctt aagtgtattg tttaactata ccattcagaa gccaaccgga agctattgac
     1201 cattaaaatt atgagaattt caaaaaaaaa aaaaaaaa
//
