LOCUS       NM_134142               1943 bp    mRNA    linear   ROD 17-FEB-2025
DEFINITION  Mus musculus transmembrane protein 109 (Tmem109), mRNA.
ACCESSION   NM_134142
VERSION     NM_134142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Gorji,A.E., Ahmadian,K., Roudbari,Z. and Sadkowski,T.
  TITLE     Identification and analysis of differentially expressed lncRNAs and
            their ceRNA networks in DMD/mdx primary myoblasts
  JOURNAL   Sci Rep 14 (1), 23691 (2024)
   PUBMED   39390091
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Watanabe,D., Nishi,M., Liu,F., Bian,Y. and Takeshima,H.
  TITLE     Ca2+ storage function is altered in the sarcoplasmic reticulum of
            skeletal muscle lacking mitsugumin 23
  JOURNAL   Am J Physiol Cell Physiol 326 (3), C795-C809 (2024)
   PUBMED   38223925
  REMARK    GeneRIF: Ca[2+] storage function is altered in the sarcoplasmic
            reticulum of skeletal muscle lacking mitsugumin 23.
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Reilly-O'Donnell,B., Robertson,G.B., Karumbi,A., McIntyre,C.,
            Bal,W., Nishi,M., Takeshima,H., Stewart,A.J. and Pitt,S.J.
  TITLE     Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine
            receptor and mitsugumin 23 functions, leading to sarcoplasmic
            reticulum Ca2+ leakage
  JOURNAL   J Biol Chem 292 (32), 13361-13373 (2017)
   PUBMED   28630041
  REMARK    GeneRIF: Data, including data from studies in vesicles of knockout
            mice, suggest pathophysiological levels of Zn2+ (>2nM) cause
            dysregulation of RyR2 opening; in sarcoplasmic reticulum, RyR2 are
            not the only Ca2+-channels regulated by Zn2+; in cardiomyocytes
            exposed to ischemic/hypoxic conditions, intracellular Zn2+ levels
            are elevated, coinciding with increased MG23 expression. (RyR2 =
            ryanodine receptor 2; MG23 = mitsugumin 23)
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Yamashita,A., Taniwaki,T., Kaikoi,Y. and Yamazaki,T.
  TITLE     Protective role of the endoplasmic reticulum protein mitsugumin23
            against ultraviolet C-induced cell death
  JOURNAL   FEBS Lett 587 (9), 1299-1303 (2013)
   PUBMED   23542032
  REMARK    GeneRIF: MG23 plays a protective role against UVC by accumulating
            alphaBC in the close vicinity of the ER
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Bjork,B.C., Turbe-Doan,A., Prysak,M., Herron,B.J. and Beier,D.R.
  TITLE     Prdm16 is required for normal palatogenesis in mice
  JOURNAL   Hum Mol Genet 19 (5), 774-789 (2010)
   PUBMED   20007998
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   Yamazaki,T., Sasaki,N., Nishi,M. and Takeshima,H.
  TITLE     Facilitation of DNA damage-induced apoptosis by endoplasmic
            reticulum protein mitsugumin23
  JOURNAL   Biochem Biophys Res Commun 392 (2), 196-200 (2010)
   PUBMED   20060811
  REMARK    GeneRIF: MG23 is an essential component of ER-generated lethal
            signals provoked upon DNA damage, specifying cell fate under
            pathophysiological conditions.
REFERENCE   7  (bases 1 to 1943)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   8  (bases 1 to 1943)
  AUTHORS   Nishi,M., Komazaki,S., Iino,M., Kangawa,K. and Takeshima,H.
  TITLE     Mitsugumin23, a novel transmembrane protein on endoplasmic
            reticulum and nuclear membranes
  JOURNAL   FEBS Lett 432 (3), 191-196 (1998)
   PUBMED   9720923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC022997.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022997.1, AK049148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.29 cM"
     gene            1..1943
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /note="transmembrane protein 109"
                     /db_xref="GeneID:68539"
                     /db_xref="MGI:MGI:1915789"
     exon            1..92
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            93..337
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..832
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /note="mg23; mitsugumin-23; mitsugumin23; voltage-gated
                     monoatomic cation channel TMEM109"
                     /codon_start=1
                     /product="voltage-gated monoatomic cation channel TMEM109
                     precursor"
                     /protein_id="NP_598903.1"
                     /db_xref="CCDS:CCDS29590.1"
                     /db_xref="GeneID:68539"
                     /db_xref="MGI:MGI:1915789"
                     /translation="MAGAHSTPLWSRHLLKAVLMVLVALFLVHSASAQSHREFASPGQ
                     QKKETSADILTQIGRSLKEMLDTWLGPETMHVISETLLQVMWAISSAISVACFALSGI
                     AAQLLSALGLDGEQLTQGLKLSPSQVQTLLLWGAAALVIYWLLSLLLGLVLALLGRIL
                     GGLKLVLFVAGFVALVRSVPDPSTRALMLLALLTLFALLSRLTGSRSSGSHLEAKVRG
                     LERQIEELRGRQRRAAKMPRSMEEE"
     exon            338..440
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1930
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1930
                     /gene="Tmem109"
                     /gene_synonym="1110006I15Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctataaacca acaccccggg agttgaggcg ccggtttggt ggcgcgtttt ctagcgaagt
       61 cccacgtgaa ggatagcggt gaccggagca ggacacaaac atggcaggcg cacacagcac
      121 tccgttatgg agcagacatc tgctcaaagc tgtcctgatg gtcctcgtgg cccttttcct
      181 cgtccactcc gcatcagccc agtctcatcg agagtttgcc tcacctggtc aacagaagaa
      241 ggagacctca gctgatattt tgacccagat tggccgatct ctgaaggaga tgttggatac
      301 ctggctaggg ccagagacca tgcatgtgat ttcagagacc ctgttgcagg tgatgtgggc
      361 catctcatca gccatctctg tggcctgctt tgccctgtct gggattgctg cccagttgct
      421 gagtgccctg gggctggatg gtgaacaact cacccagggc ttgaagctca gccctagcca
      481 agtccagacc cttctactgt ggggagcagc agcactggtc atctactggt tgctgtccct
      541 gctcctaggc ttggtcttgg ccttgctagg gaggatcctg gggggtctga aacttgttct
      601 ttttgtcgct ggctttgtgg ccctggtgag gtctgtgccc gacccatcta cccgggcctt
      661 gatgctcttg gccttgttaa ctctctttgc cttgctgagc cggctcactg gctccaggag
      721 ctcagggagc cacctggaag ccaaggtgag agggctggag cgccagatag aagagcttag
      781 agggaggcag aggcgagcag ccaagatgcc caggagcatg gaagaagagt gacaagggcg
      841 tccccaagag acaccctcac cgtaccaaag agctgagctg cttctgggtc tcacggacct
      901 ccttgcagcc cccttgccct ttccttgcct tgtgtccgga accttcacac ctttacccct
      961 gcgctagccc ctggctgaga ggagagaacc tgtcctctgc cggtgctcag tcaagtgatg
     1021 gctccctgcc cttctgtgct cccagcctgc ctcccccagg gcaggttgga gccctcagcc
     1081 ctggcttctg ctctcagcca gcaccactgc ccgctgatct ccgtgatgat taacctgctg
     1141 cttccttaca caaggcctgc ccaggctgaa gctcctgttt gaccactccc cccccccccc
     1201 cccagctctt ttcttcctgc tcccagccac actaccatcc caagtccctt gcggccctct
     1261 ctgtcttcct cattgcactg caatgggcag gggtaggaga ttggagataa ggatgaaggg
     1321 ggaggaaagg gtccctggag gcctgtgcat ctatgctctg ttacaagtgc cttagcagga
     1381 gtcagcagca ccctccaggt gccccttgcc acactgaatg tgggaaagtg tgctgtggct
     1441 acttcgtggt cagagtgagc cccttgcaga atccccactc cagcaaacaa agcaacggcc
     1501 ctgctgggat tgtcgaatct cccttgaggg tttcagggac cttgaaaagg gcaggaggac
     1561 ctgctgtctt gcagttttac ccctgtccac tctctgccat ccagaagcaa gcgttggtca
     1621 gtgttgtgtc ccagtagctg ggaagggcac ggctttgccc tgatctgttc tgcagggcta
     1681 ggagtgagcc tgccactaac ccctctccac cacttgctca ctcttggcct tggccttggc
     1741 ctttaggtcc ctggtggagg gagatgaccc atgccaggtc cagcacaaga tgtgaagatt
     1801 aaatgcctat tcttactgaa ggtttgatgt ggaatcatgg ctgcagtgat atgtttttat
     1861 cagcgcttgg tggttttaaa gtgcatgcta ttttattatc ttcttctgaa taaaatgtat
     1921 ttactcaaaa aaaaaaaaaa aaa
//
