LOCUS       NM_178638               3692 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protein 108 (Tmem108), transcript
            variant 1, mRNA.
ACCESSION   NM_178638 XM_973508 XM_978572
VERSION     NM_178638.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3692)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3692)
  AUTHORS   Wu,Y., Zhong,Y., Liao,X., Miao,X., Yu,J., Lai,X., Zhang,Y., Ma,C.,
            Pan,H. and Wang,S.
  TITLE     Transmembrane protein 108 inhibits the proliferation and
            myelination of oligodendrocyte lineage cells in the corpus callosum
  JOURNAL   Mol Brain 15 (1), 33 (2022)
   PUBMED   35410424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3692)
  AUTHORS   Yu,J., Liao,X., Zhong,Y., Wu,Y., Lai,X., Jiao,H., Yan,M., Zhang,Y.,
            Ma,C. and Wang,S.
  TITLE     The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose
            Metabolism Homeostasis
  JOURNAL   Front Endocrinol (Lausanne) 12, 770145 (2021)
   PUBMED   34690937
  REMARK    GeneRIF: The Candidate Schizophrenia Risk Gene Tmem108 Regulates
            Glucose Metabolism Homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3692)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3692)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   7  (bases 1 to 3692)
  AUTHORS   Fu,X., Yang,Y., Xu,C., Niu,Y., Chen,T., Zhou,Q. and Liu,J.J.
  TITLE     Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB
            early endocytic trafficking and signaling from early endosomes
  JOURNAL   Mol Biol Cell 22 (19), 3684-3698 (2011)
   PUBMED   21849472
  REMARK    GeneRIF: retrolinkin functions in the endocytic trafficking of
            BDNF-TrkB and mediates BDNF-triggered ERK signaling in CNS neurons
REFERENCE   8  (bases 1 to 3692)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 3692)
  AUTHORS   Liu,J.J., Ding,J., Wu,C., Bhagavatula,P., Cui,B., Chu,S.,
            Mobley,W.C. and Yang,Y.
  TITLE     Retrolinkin, a membrane protein, plays an important role in
            retrograde axonal transport
  JOURNAL   Proc Natl Acad Sci U S A 104 (7), 2223-2228 (2007)
   PUBMED   17287360
REFERENCE   10 (bases 1 to 3692)
  AUTHORS   Omran,H., Haffner,K., Burth,S., Fernandez,C., Fargier,B.,
            Villaquiran,A., Nothwang,H.G., Schnittger,S., Lehrach,H., Woo,D.,
            Brandis,M., Sudbrak,R. and Hildebrandt,F.
  TITLE     Human adolescent nephronophthisis: gene locus synteny with
            polycystic kidney disease in pcy mice
  JOURNAL   J Am Soc Nephrol 12 (1), 107-113 (2001)
   PUBMED   11134256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052330.1 and AC165256.2.
            
            On Feb 4, 2010 this sequence version replaced NM_178638.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052330.1, AK141589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2130              AK052330.1         1-2130
            2131-3692           AC165256.2         124131-125692
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.47 cM"
     gene            1..3692
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /note="transmembrane protein 108"
                     /db_xref="GeneID:81907"
                     /db_xref="MGI:MGI:1932411"
     exon            1..83
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            84..196
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            197..282
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1967
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /note="retrolinkin"
                     /codon_start=1
                     /product="transmembrane protein 108 precursor"
                     /protein_id="NP_848753.1"
                     /db_xref="CCDS:CCDS23455.1"
                     /db_xref="GeneID:81907"
                     /db_xref="MGI:MGI:1932411"
                     /translation="MKRSLQALYCQLLSFLLTLALTKALVLAVHEPSPRESLQTLPSG
                     SPPGTMVTAPHSPTRLSSVLTLNPTPDGPSSQAAATLETTVSHPEGHPPTDTTSTVMG
                     TAAVPHPESPLPTGSPPAAMTTTPSHSESLPPGDATPTTTLPTKPAGTTSRPTVAPRA
                     TTRRPPRPPGSSRKGAGGSTRTLTPVPGGHLARKESQRGRNQSSAHLGPKRPLGKIFQ
                     IYKGNFTGSAEPDPSALTPRTPLGGYFSSTQPQTVSPATAPRSTSRVPPTTSLVPVKD
                     KPGFIRSNQGSGPILTSPGGEPAATAATGAPASTQPAPVPSQSPHGDVQDSASHSDSW
                     LAVTPDTDRPTSASSGVFTAATGPTQAAFDATVSAPSPGIPQGPSATPQAPTRPSGVS
                     ESTVSPAEEEAEASPTTTDRGPRPLSTVLSTATGNFLNRLVPAGTWKPGTVANISHVA
                     EGDKPQHRATICLSKMDIAWVIVAISVPISSCSVLLTVCCMRRKKKTANPENNLSYWN
                     NAITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFV
                     GNDQVSEI"
     exon            283..1689
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1844
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..3692
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2192
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
                     /note="major polyA site"
     polyA_site      3305
                     /gene="Tmem108"
                     /gene_synonym="B130017P16Rik"
ORIGIN      
        1 gaaggcgcga gtgcgcgtgc gcgagcgcga gcggcggggc tttctccgga gccgtcggag
       61 ggagccggag cgcttctccc gagatcgctt tgctgtggtc cagcatgcag aagtaagcgt
      121 gtggtgaaag gcagcagatc cgatgggttg cgaggatgta agatcgtctg aaggcttcca
      181 caccctctcc tccaggacag aatcatgaat aaactggagg accagcagga ccagatgata
      241 ccatgaagag aagtttacag gccctctatt gccaactatt aagctttctc ctgaccttgg
      301 cactgaccaa agcactggta ctcgctgtcc acgaaccatc tcccagggaa tctctacaga
      361 ccctcccctc aggcagcccc ccaggcacca tggtgacagc acctcacagc cctaccagac
      421 tctcctctgt gctgacactg aatcctacac ctgatggacc ctcatcacag gctgcagcta
      481 ctctggaaac tacagtatct catccagaag ggcaccctcc tacagacacc acgtctacag
      541 tgatggggac agctgccgtc ccgcatcccg aaagtcctct gcccacaggg tcccctccag
      601 ctgccatgac aaccacaccc tcccactcag agagcctccc cccaggggat gctaccccca
      661 ccactaccct gccaacaaag ccagcaggaa ccaccagccg ccccacagtg gccccacggg
      721 ccaccactcg tcggcccccc agacccccgg gctcttccag gaagggggct ggtggttcga
      781 ctcgcactct cacacccgta ccgggtggcc acttggccag gaaggaaagc cagaggggac
      841 gaaaccagag ctcagcacat ctggggccga agcgtcctct ggggaagatc ttccaaatct
      901 acaagggtaa ctttacgggg tctgcggagc cagacccctc cgcgctcacg cccaggaccc
      961 cactcggggg ctacttctct tcgacacagc cccagacagt gtctccagct acagcaccca
     1021 gaagcacctc acgggtgccc cccacaactt ccctggtacc tgtaaaggac aagccaggct
     1081 ttatcagatc caaccagggg agtggcccca tccttaccag cccaggaggg gagccagctg
     1141 ccacagcagc cacaggtgcc cctgccagta cacagcctgc cccagtgcct tctcagagcc
     1201 ctcatggtga cgtgcaggac agcgccagcc acagtgactc ttggcttgct gtcacacctg
     1261 acactgacag acccacgtct gccagctccg gggtcttcac ggctgccaca gggcccaccc
     1321 aggctgcctt tgatgccact gtctcagccc cttccccggg catccctcag ggaccatctg
     1381 caacccctca ggccccaacc cggccctctg gggtctcaga aagcactgtt tctccagcag
     1441 aggaagaggc tgaggcctcc cccacgacaa ccgacagggg ccccagacct ctctccacag
     1501 tgctgtccac agccacgggc aacttcctca accgcctggt ccctgctggg acctggaagc
     1561 cggggactgt ggccaacatc tcccacgtgg ctgaagggga caaaccccag cacagagcca
     1621 ccatctgctt gagcaagatg gatattgcct gggtcatcgt ggccatcagt gtccccatct
     1681 cctcctgctc ggtcctgttg acagtgtgct gcatgaggag gaagaagaag acggccaacc
     1741 ctgagaacaa cctgagctac tggaacaatg ccatcacaat ggactacttc aacagacacg
     1801 cggtggagct cccgagggag atccagtccc tagagacctc agaggaccag ctctcagagc
     1861 cccgctcccc agccaatggc gactatcgag acactgggat ggtcctcgtg aaccccttct
     1921 gccaggaaac actgttcgtg ggaaacgacc aagtttccga gatctagatg cagcagcctc
     1981 cgctttgcca ctccctattt ttgtctctaa attataaata tacaaatata tatattataa
     2041 atataacctt tgtgtaaccc tgacttaata agagacattt tcagcttttt ttcctaagaa
     2101 ttgtcaacat cttttttaca agtgtggttt aaaaaaaaaa aaatttacag aatgacccat
     2161 ggctttataa aataaaggta tttctaagca aagcggttgc actgattgct tctcttaact
     2221 gttctgggca tgtagaggtt ccaggagccc tgggcagatg aggaaagaga ccaatctccc
     2281 gtggaagctg aacgttagtg tggccaagtg agtggtcatc tgcgtggtct tgatgctctg
     2341 gttcccagga ctcagtgtgc cctcatctcc tgtctttttg tatgtatcct agtggtgggg
     2401 ataggggcac cacagtggag gacacaggca ggtggtgtgc aaaacggaag ggaacggtgc
     2461 cagcctggag cctcactgta gcatcactga atgtcgagtt tgacaggatc ggtggaggcc
     2521 atcaagagcc tccagccccc ttttatgacc ccacaggatg ctcccaccat gctagaagaa
     2581 acaggactgc ctttgtctgg caggaaagtg gtccctagaa actcttctca gcatcccttc
     2641 taacatccct gcctgccctt ggatgccctg cctctcttcc tggaggacag atgcagatct
     2701 cagcccttgc ccttcactgt tcaagtgttg gttgggattc agtattgctt tctccaaagg
     2761 caatgatatt gtgctccatg agaaacaggt ttatctatta agccttgcag tgtagaacta
     2821 ttttttttaa ccttccccca ttaaatcttt aaagaaaaaa ataaaagatt gccaaatgac
     2881 tcacttgaaa gaagtgccat tctgtctaca ggcagaagca cggcagacct gcccacaaac
     2941 ttgccatccg ctttcgctgt cccctgtccc ccccaaaccc ccttgttccc ctgggtccgg
     3001 gtccagctgc cttccccagc ccacactgta cccagcgtgg ccaacaagga tctctcagag
     3061 acccaagagg ggtttctgga gccaattgct tttctctgtt actttcctaa cctgtcatgg
     3121 ctagggattt aacttcaacc cctcccccct tctctaaaag aaaataatag tttgatagta
     3181 tattttgaat atagatgttc ttatcagatt ggagcttgaa tttgtctgtt gatttccatg
     3241 tctgtgttgt tgctgtgatt ttctcatcag gactgcctct cttcttccat tccccttttc
     3301 caaaagaaag acggccttca aaactaatgt gtgtttctca atgttacatg gacctactta
     3361 gagtctgctt gtctctcttc aaagacttca acccacaaag aagcaggtta aatgttgtgc
     3421 cgagatttcg ctctctaaca tgttgctgtc tgaccttaac cttatcataa tatttctgtt
     3481 agctactgcg ttgaatatac caatgtgtgt gagtatgtat tgaagaaaac atgtttgtaa
     3541 agtaaaattt atatataata tatgtcatca aagatacata tgttatatat atatacattt
     3601 gtggacgtat gacttatttt tccgtatcca cagaattcag ctaccatgta tatataaata
     3661 aacttatttt attacccaga ggaccaagtc gc
//
