LOCUS       NM_028336               1281 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus transmembrane protein 107 (Tmem107), transcript
            variant 2, mRNA.
ACCESSION   NM_028336
VERSION     NM_028336.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Dubaic,M., Peskova,L., Hampl,M., Weissova,K., Celiker,C.,
            Shylo,N.A., Hruba,E., Kavkova,M., Zikmund,T., Weatherbee,S.D.,
            Kaiser,J., Barta,T. and Buchtova,M.
  TITLE     Role of ciliopathy protein TMEM107 in eye development: insights
            from a mouse model and retinal organoid
  JOURNAL   Life Sci Alliance 6 (12), e202302073 (2023)
   PUBMED   37863656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Shylo,N.A., Emmanouil,E., Ramrattan,D. and Weatherbee,S.D.
  TITLE     Loss of ciliary transition zone protein TMEM107 leads to heterotaxy
            in mice
  JOURNAL   Dev Biol 460 (2), 187-199 (2020)
   PUBMED   31887266
  REMARK    GeneRIF: Loss of ciliary transition zone protein TMEM107 leads to
            heterotaxy in mice.
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Cela,P., Hampl,M., Shylo,N.A., Christopher,K.J., Kavkova,M.,
            Landova,M., Zikmund,T., Weatherbee,S.D., Kaiser,J. and Buchtova,M.
  TITLE     Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial
            Development
  JOURNAL   J Dent Res 97 (1), 108-117 (2018)
   PUBMED   28954202
  REMARK    GeneRIF: multiple roles in craniofacial development
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Shylo,N.A., Christopher,K.J., Iglesias,A., Daluiski,A. and
            Weatherbee,S.D.
  TITLE     TMEM107 Is a Critical Regulator of Ciliary Protein Composition and
            Is Mutated in Orofaciodigital Syndrome
  JOURNAL   Hum Mutat 37 (2), 155-159 (2016)
   PUBMED   26518474
  REMARK    GeneRIF: TMEM107 Is a critical regulator of ciliary protein
            composition and is mutated in orofaciodigital syndrome mice.
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Lambacher,N.J., Bruel,A.L., van Dam,T.J., Szymanska,K.,
            Slaats,G.G., Kuhns,S., McManus,G.J., Kennedy,J.E., Gaff,K.,
            Wu,K.M., van der Lee,R., Burglen,L., Doummar,D., Riviere,J.B.,
            Faivre,L., Attie-Bitach,T., Saunier,S., Curd,A., Peckham,M.,
            Giles,R.H., Johnson,C.A., Huynen,M.A., Thauvin-Robinet,C. and
            Blacque,O.E.
  TITLE     TMEM107 recruits ciliopathy proteins to subdomains of the ciliary
            transition zone and causes Joubert syndrome
  JOURNAL   Nat Cell Biol 18 (1), 122-131 (2016)
   PUBMED   26595381
  REMARK    GeneRIF: TMEM107 recruits ciliopathy proteins to subdomains of the
            ciliary transition zone and causes Joubert syndrome
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Christopher,K.J., Wang,B., Kong,Y. and Weatherbee,S.D.
  TITLE     Forward genetics uncovers Transmembrane protein 107 as a novel
            factor required for ciliogenesis and Sonic hedgehog signaling
  JOURNAL   Dev Biol 368 (2), 382-392 (2012)
   PUBMED   22698544
  REMARK    GeneRIF: Data show that Transmembrane protein 107 (Tmem107) is
            required for normal Sonic hedgehog (Shh) signaling in the neural
            tube and acts in combination with Gli2 and Gli3 to pattern ventral
            and intermediate neuronal cell types.
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA217716.1, AK003403.1, AK012938.1 and AI835650.1.
            
            [WARNING] On May 31, 2024 this sequence was replaced by
            NM_028336.4.
            
            On May 28, 2009 this sequence version replaced NM_028336.2.
            
            Transcript Variant: This variant (2) is the longer transcript and
            encodes the longer isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012938.1, BY712023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AA217716.1         4-7
            5-491               AK003403.1         1-487
            492-1264            AK012938.1         491-1263
            1265-1281           AI835650.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.35 cM"
     gene            1..1281
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /note="transmembrane protein 107"
                     /db_xref="GeneID:66910"
                     /db_xref="MGI:MGI:1914160"
     exon            1..225
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..570
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 107 isoform 2"
                     /protein_id="NP_082612.2"
                     /db_xref="CCDS:CCDS24880.1"
                     /db_xref="GeneID:66910"
                     /db_xref="MGI:MGI:1914160"
                     /translation="MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPE
                     EYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVF
                     ERWECTTYWYIFTFCRCPSTQYFGMGGGGGKSIPNLKVSPT"
     exon            226..293
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..394
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..1265
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggcggc gcccgagcgc gcgggaagga cacttaagta gagaggtctg gcctgcttgc
       61 tcagggagac ttgatgagtg acccacccca gacttccaac ctcaaaaccc acggcctcca
      121 ctcgaggccc ccgaggccat gggtcggatc tccgggctcg tgccctctcg gttcctgacg
      181 ctcttggctc atctggtggt tgtcatcacg ttgttctggt cccgggaaag caacatccag
      241 gcttgcctgc ctctcaaatt caccccggag gaatacgaaa agcaggacaa ccagctggta
      301 gccgcgctct gtctcaccct gggcctcttt gcagtggagc tggctggctt cctctcagga
      361 gtctccatgt tcaatagcac ccagagcctc ctctccattg cagcccactg tagcgcgtct
      421 gtggccctgt ctttcttcgt attcgagcga tgggaatgta ccacgtactg gtacattttt
      481 accttctgca ggtgccctag cacccaatat tttggaatgg gggggggtgg tggaaaatcg
      541 atcccaaatc tgaaggtttc ccccacctag acctttcctg cacatgtgaa attggtagag
      601 ttttgaagag tcatacccac cctaacccac ccgcatataa ggtttggagg ttcaagtgtt
      661 tgggttggaa ggggctctaa ctcccccccc tcccccgcgg ccccgtactt ttcacagcgc
      721 cttcccagct gtcactgaaa ctgcattatt catcgctgtc tttgggctga aaaagaaacc
      781 cttctgatca caatccgggt gtagggacca aggctggaaa agtgatgaag cttcctccca
      841 ctgctgcaag aaaaaggcag aggcttcagt tttctctcgc ccaagtccct tgctcctccc
      901 aactgcggct aagcagagga tggcagtgtt ggaataagat ctctcaaatc ttggattata
      961 attttattag agttttgtaa taaaatttat tttataacaa gagcaaggcg tatactattt
     1021 ttcagaagac cattggatgg gccaagaggc tggtataaat aaaggctttt atcttgtggt
     1081 tagggctaga agtaatgctt ctatttgggt ttttacgcta gaagctaggc ggaagtgagt
     1141 gggcggggat atgcaaataa ctatctcaca tagcgcttct aatttgccgc gtgtgagggg
     1201 agcattctgg gatggttttg tttctccctt tttgtgccga atggagaata aaatacttca
     1261 aacgaaaaaa aaaaaaaaaa a
//
