LOCUS       NM_025838               1056 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus transmembrane protein 107 (Tmem107), transcript
            variant 1, mRNA.
ACCESSION   NM_025838
VERSION     NM_025838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Dubaic,M., Peskova,L., Hampl,M., Weissova,K., Celiker,C.,
            Shylo,N.A., Hruba,E., Kavkova,M., Zikmund,T., Weatherbee,S.D.,
            Kaiser,J., Barta,T. and Buchtova,M.
  TITLE     Role of ciliopathy protein TMEM107 in eye development: insights
            from a mouse model and retinal organoid
  JOURNAL   Life Sci Alliance 6 (12), e202302073 (2023)
   PUBMED   37863656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Shylo,N.A., Emmanouil,E., Ramrattan,D. and Weatherbee,S.D.
  TITLE     Loss of ciliary transition zone protein TMEM107 leads to heterotaxy
            in mice
  JOURNAL   Dev Biol 460 (2), 187-199 (2020)
   PUBMED   31887266
  REMARK    GeneRIF: Loss of ciliary transition zone protein TMEM107 leads to
            heterotaxy in mice.
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Cela,P., Hampl,M., Shylo,N.A., Christopher,K.J., Kavkova,M.,
            Landova,M., Zikmund,T., Weatherbee,S.D., Kaiser,J. and Buchtova,M.
  TITLE     Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial
            Development
  JOURNAL   J Dent Res 97 (1), 108-117 (2018)
   PUBMED   28954202
  REMARK    GeneRIF: multiple roles in craniofacial development
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Shylo,N.A., Christopher,K.J., Iglesias,A., Daluiski,A. and
            Weatherbee,S.D.
  TITLE     TMEM107 Is a Critical Regulator of Ciliary Protein Composition and
            Is Mutated in Orofaciodigital Syndrome
  JOURNAL   Hum Mutat 37 (2), 155-159 (2016)
   PUBMED   26518474
  REMARK    GeneRIF: TMEM107 Is a critical regulator of ciliary protein
            composition and is mutated in orofaciodigital syndrome mice.
REFERENCE   6  (bases 1 to 1056)
  AUTHORS   Lambacher,N.J., Bruel,A.L., van Dam,T.J., Szymanska,K.,
            Slaats,G.G., Kuhns,S., McManus,G.J., Kennedy,J.E., Gaff,K.,
            Wu,K.M., van der Lee,R., Burglen,L., Doummar,D., Riviere,J.B.,
            Faivre,L., Attie-Bitach,T., Saunier,S., Curd,A., Peckham,M.,
            Giles,R.H., Johnson,C.A., Huynen,M.A., Thauvin-Robinet,C. and
            Blacque,O.E.
  TITLE     TMEM107 recruits ciliopathy proteins to subdomains of the ciliary
            transition zone and causes Joubert syndrome
  JOURNAL   Nat Cell Biol 18 (1), 122-131 (2016)
   PUBMED   26595381
  REMARK    GeneRIF: TMEM107 recruits ciliopathy proteins to subdomains of the
            ciliary transition zone and causes Joubert syndrome
REFERENCE   7  (bases 1 to 1056)
  AUTHORS   Christopher,K.J., Wang,B., Kong,Y. and Weatherbee,S.D.
  TITLE     Forward genetics uncovers Transmembrane protein 107 as a novel
            factor required for ciliogenesis and Sonic hedgehog signaling
  JOURNAL   Dev Biol 368 (2), 382-392 (2012)
   PUBMED   22698544
  REMARK    GeneRIF: Data show that Transmembrane protein 107 (Tmem107) is
            required for normal Sonic hedgehog (Shh) signaling in the neural
            tube and acts in combination with Gli2 and Gli3 to pattern ventral
            and intermediate neuronal cell types.
REFERENCE   8  (bases 1 to 1056)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA217716.1, AK003403.1 and CO044635.1.
            
            [WARNING] On May 31, 2024 this sequence was replaced by
            NM_025838.3.
            
            On May 28, 2009 this sequence version replaced NM_025838.1.
            
            Transcript Variant: This variant (1) lacks an internal segment in
            the 3' region, as compared to variant 2. The resulting isoform (1)
            is shorter and has a different C-terminus, as compared to isoform
            2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154279.1, AK003403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AA217716.1         4-7
            5-772               AK003403.1         1-768
            773-1056            CO044635.1         1-284               c
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.35 cM"
     gene            1..1056
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /note="transmembrane protein 107"
                     /db_xref="GeneID:66910"
                     /db_xref="MGI:MGI:1914160"
     exon            1..225
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..561
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 107 isoform 1"
                     /protein_id="NP_080114.1"
                     /db_xref="CCDS:CCDS24879.1"
                     /db_xref="GeneID:66910"
                     /db_xref="MGI:MGI:1914160"
                     /translation="MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPE
                     EYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVF
                     ERWECTTYWYIFTFCSAFPAVTETALFIAVFGLKKKPF"
     exon            226..293
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..394
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..491
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..1039
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggcggc gcccgagcgc gcgggaagga cacttaagta gagaggtctg gcctgcttgc
       61 tcagggagac ttgatgagtg acccacccca gacttccaac ctcaaaaccc acggcctcca
      121 ctcgaggccc ccgaggccat gggtcggatc tccgggctcg tgccctctcg gttcctgacg
      181 ctcttggctc atctggtggt tgtcatcacg ttgttctggt cccgggaaag caacatccag
      241 gcttgcctgc ctctcaaatt caccccggag gaatacgaaa agcaggacaa ccagctggta
      301 gccgcgctct gtctcaccct gggcctcttt gcagtggagc tggctggctt cctctcagga
      361 gtctccatgt tcaatagcac ccagagcctc ctctccattg cagcccactg tagcgcgtct
      421 gtggccctgt ctttcttcgt attcgagcga tgggaatgta ccacgtactg gtacattttt
      481 accttctgca gcgccttccc agctgtcact gaaactgcat tattcatcgc tgtctttggg
      541 ctgaaaaaga aacccttctg atcacaatcc gggtgtaggg accaaggctg gaaaagtgat
      601 gaagcttcct cccactgctg caagaaaaag gcagaggctt cagttttctc tcgcccaagt
      661 cccttgctcc tcccaactgc ggctaagcag aggatggcag tgttggaata agatctctca
      721 aatcttggat tataatttta ttagagtttt gtaataaaat ttattttata acaagagcaa
      781 ggcgtatact atttttcaga agaccattgg atgggccaag aggctggtat aaataaaggc
      841 ttttatcttg tggttagggc tagaagtaat gcttctattt gggtttttac gctagaagct
      901 aggcggaagt gagtgggcgg ggatatgcaa ataactatct cacatagcgc ttctaatttg
      961 ccgcgtgtga ggggagcatt ctgggatggt tttgtttctc cctttttgtg ccgaatggag
     1021 aataaaatac ttcaaacgaa aaaaaaaaaa aaaaaa
//
