LOCUS       NP_080114                140 aa            linear   ROD 05-MAY-2025
DEFINITION  transmembrane protein 107 isoform 1 [Mus musculus].
ACCESSION   NP_080114
VERSION     NP_080114.1
DBSOURCE    REFSEQ: accession NM_025838.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 140)
  AUTHORS   Dubaic,M., Peskova,L., Hampl,M., Weissova,K., Celiker,C.,
            Shylo,N.A., Hruba,E., Kavkova,M., Zikmund,T., Weatherbee,S.D.,
            Kaiser,J., Barta,T. and Buchtova,M.
  TITLE     Role of ciliopathy protein TMEM107 in eye development: insights
            from a mouse model and retinal organoid
  JOURNAL   Life Sci Alliance 6 (12), e202302073 (2023)
   PUBMED   37863656
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 140)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 140)
  AUTHORS   Shylo,N.A., Emmanouil,E., Ramrattan,D. and Weatherbee,S.D.
  TITLE     Loss of ciliary transition zone protein TMEM107 leads to heterotaxy
            in mice
  JOURNAL   Dev Biol 460 (2), 187-199 (2020)
   PUBMED   31887266
  REMARK    GeneRIF: Loss of ciliary transition zone protein TMEM107 leads to
            heterotaxy in mice.
REFERENCE   4  (residues 1 to 140)
  AUTHORS   Cela,P., Hampl,M., Shylo,N.A., Christopher,K.J., Kavkova,M.,
            Landova,M., Zikmund,T., Weatherbee,S.D., Kaiser,J. and Buchtova,M.
  TITLE     Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial
            Development
  JOURNAL   J Dent Res 97 (1), 108-117 (2018)
   PUBMED   28954202
  REMARK    GeneRIF: multiple roles in craniofacial development
REFERENCE   5  (residues 1 to 140)
  AUTHORS   Shylo,N.A., Christopher,K.J., Iglesias,A., Daluiski,A. and
            Weatherbee,S.D.
  TITLE     TMEM107 Is a Critical Regulator of Ciliary Protein Composition and
            Is Mutated in Orofaciodigital Syndrome
  JOURNAL   Hum Mutat 37 (2), 155-159 (2016)
   PUBMED   26518474
  REMARK    GeneRIF: TMEM107 Is a critical regulator of ciliary protein
            composition and is mutated in orofaciodigital syndrome mice.
REFERENCE   6  (residues 1 to 140)
  AUTHORS   Lambacher,N.J., Bruel,A.L., van Dam,T.J., Szymanska,K.,
            Slaats,G.G., Kuhns,S., McManus,G.J., Kennedy,J.E., Gaff,K.,
            Wu,K.M., van der Lee,R., Burglen,L., Doummar,D., Riviere,J.B.,
            Faivre,L., Attie-Bitach,T., Saunier,S., Curd,A., Peckham,M.,
            Giles,R.H., Johnson,C.A., Huynen,M.A., Thauvin-Robinet,C. and
            Blacque,O.E.
  TITLE     TMEM107 recruits ciliopathy proteins to subdomains of the ciliary
            transition zone and causes Joubert syndrome
  JOURNAL   Nat Cell Biol 18 (1), 122-131 (2016)
   PUBMED   26595381
  REMARK    GeneRIF: TMEM107 recruits ciliopathy proteins to subdomains of the
            ciliary transition zone and causes Joubert syndrome
REFERENCE   7  (residues 1 to 140)
  AUTHORS   Christopher,K.J., Wang,B., Kong,Y. and Weatherbee,S.D.
  TITLE     Forward genetics uncovers Transmembrane protein 107 as a novel
            factor required for ciliogenesis and Sonic hedgehog signaling
  JOURNAL   Dev Biol 368 (2), 382-392 (2012)
   PUBMED   22698544
  REMARK    GeneRIF: Data show that Transmembrane protein 107 (Tmem107) is
            required for normal Sonic hedgehog (Shh) signaling in the neural
            tube and acts in combination with Gli2 and Gli3 to pattern ventral
            and intermediate neuronal cell types.
REFERENCE   8  (residues 1 to 140)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645902.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003403.1, AK154279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..140
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.35 cM"
     Protein         1..140
                     /product="transmembrane protein 107 isoform 1"
                     /calculated_mol_wt=15462
     Region          7..129
                     /region_name="TMEM107"
                     /note="Transmembrane protein; pfam14995"
                     /db_xref="CDD:464430"
     Site            7..27
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV0.1)"
     Site            53..73
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV0.1)"
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9CPV0.1)"
     Site            83..103
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV0.1)"
     Site            113..133
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV0.1)"
     CDS             1..140
                     /gene="Tmem107"
                     /gene_synonym="1110004B13Rik; 2810049P21Rik"
                     /coded_by="NM_025838.3:145..567"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24879.1"
                     /db_xref="GeneID:66910"
                     /db_xref="MGI:MGI:1914160"
ORIGIN      
        1 mgrisglvps rfltllahlv vvitlfwsre sniqaclplk ftpeeyekqd nqlvaalclt
       61 lglfavelag flsgvsmfns tqsllsiaah csasvalsff vferwectty wyiftfcsaf
      121 pavtetalfi avfglkkkpf
//
