LOCUS       NM_027992               6099 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus transmembrane protein 106B (Tmem106b), mRNA.
ACCESSION   NM_027992
VERSION     NM_027992.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6099)
  AUTHORS   Takahashi,H., Perez-Canamas,A., Lee,C.W., Ye,H., Han,X. and
            Strittmatter,S.M.
  TITLE     Lysosomal TMEM106B interacts with galactosylceramidase to regulate
            myelin lipid metabolism
  JOURNAL   Commun Biol 7 (1), 1088 (2024)
   PUBMED   39237682
  REMARK    GeneRIF: Lysosomal TMEM106B interacts with galactosylceramidase to
            regulate myelin lipid metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6099)
  AUTHORS   Picard,C., Miron,J. and Poirier,J.
  TITLE     Association of TMEM106B with Cortical APOE Gene Expression in
            Neurodegenerative Conditions
  JOURNAL   Genes (Basel) 15 (4), 416 (2024)
   PUBMED   38674351
  REMARK    GeneRIF: Association of TMEM106B with Cortical APOE Gene Expression
            in Neurodegenerative Conditions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6099)
  AUTHORS   Feng,T., Du,H., Yang,C., Wang,Y. and Hu,F.
  TITLE     Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in
            PS19 mice
  JOURNAL   Acta Neuropathol 147 (1), 62 (2024)
   PUBMED   38526799
  REMARK    GeneRIF: Loss of TMEM106B exacerbates Tau pathology and
            neurodegeneration in PS19 mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6099)
  AUTHORS   Edwards,G.A. 3rd, Wood,C.A., He,Y., Nguyen,Q., Kim,P.J.,
            Gomez-Gutierrez,R., Park,K.W., Xu,Y., Zurhellen,C., Al-Ramahi,I.
            and Jankowsky,J.L.
  TITLE     TMEM106B coding variant is protective and deletion detrimental in a
            mouse model of tauopathy
  JOURNAL   Acta Neuropathol 147 (1), 61 (2024)
   PUBMED   38526616
  REMARK    GeneRIF: TMEM106B coding variant is protective and deletion
            detrimental in a mouse model of tauopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 6099)
  AUTHORS   Zhou,X., Sun,L., Bastos de Oliveira,F., Qi,X., Brown,W.J.,
            Smolka,M.B., Sun,Y. and Hu,F.
  TITLE     Prosaposin facilitates sortilin-independent lysosomal trafficking
            of progranulin
  JOURNAL   J Cell Biol 210 (6), 991-1002 (2015)
   PUBMED   26370502
REFERENCE   7  (bases 1 to 6099)
  AUTHORS   Brady,O.A., Zhou,X. and Hu,F.
  TITLE     Regulated intramembrane proteolysis of the frontotemporal lobar
            degeneration risk factor, TMEM106B, by signal peptide
            peptidase-like 2a (SPPL2a)
  JOURNAL   J Biol Chem 289 (28), 19670-19680 (2014)
   PUBMED   24872421
  REMARK    GeneRIF: Regulated intramembrane proteolysis of the frontotemporal
            lobar degeneration risk factor, TMEM106B, by signal peptide
            peptidase-like 2a (SPPL2a).
REFERENCE   8  (bases 1 to 6099)
  AUTHORS   Stagi,M., Klein,Z.A., Gould,T.J., Bewersdorf,J. and
            Strittmatter,S.M.
  TITLE     Lysosome size, motility and stress response regulated by
            fronto-temporal dementia modifier TMEM106B
  JOURNAL   Mol Cell Neurosci 61, 226-240 (2014)
   PUBMED   25066864
REFERENCE   9  (bases 1 to 6099)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 6099)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI552875.1, BC050246.1, AK148477.1, CA751076.1, CD776556.1,
            BQ888115.1, AK078219.1 and BP760304.1.
            
            On May 14, 2008 this sequence version replaced NM_027992.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.138879.1,
                                           SRR1660819.178478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AI552875.1         17-99
            84-1874             BC050246.1         1-1791
            1875-2859           AK148477.1         1799-2783
            2860-3541           CA751076.1         43-724
            3542-4165           CD776556.1         18-641              c
            4166-4397           BQ888115.1         538-769
            4398-6073           AK078219.1         828-2503
            6074-6099           BP760304.1         30-55               c
FEATURES             Location/Qualifiers
     source          1..6099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.38 cM"
     gene            1..6099
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="transmembrane protein 106B"
                     /db_xref="GeneID:71900"
                     /db_xref="MGI:MGI:1919150"
     exon            1..202
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            203..309
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..531
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1139
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /codon_start=1
                     /product="transmembrane protein 106B"
                     /protein_id="NP_082268.2"
                     /db_xref="CCDS:CCDS19914.1"
                     /db_xref="GeneID:71900"
                     /db_xref="MGI:MGI:1919150"
                     /translation="MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVHNEDGRNG
                     DVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMAS
                     VFVCLLLSGLAVFFLFPRSIEVKYIGVKSAYVSYDAEKRTIYLNITNTLNITNNNYYS
                     VEVENITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLL
                     SIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ"
     exon            532..595
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            596..755
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..896
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            897..946
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1000
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..6082
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="major polyA site"
     regulatory      4149..4154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4167
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
     regulatory      6059..6064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6082
                     /gene="Tmem106b"
                     /gene_synonym="2310036D22Rik; 5830455K21Rik;
                     6430519M21Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgaact gcgcaagcgc acgcgcaggc tctcccggta cggagctcag ctgatgcagt
       61 tgttgtgcta cccctccccc gcagctctcc cggctgcact ctaccggcgc tcggcccggc
      121 cccgggaccg ggacgctgtg accctgtcct gcggcccgca cgcaccggag catcccggga
      181 ccgcgcagca ctccgcgtgc ggtttctaga gcatctgaga accgtgttga gttcacaaga
      241 ccgcggtata aacattgaga gcccggggag gagacgaagg ggatctacca ctccctttaa
      301 aaacctcaaa catgggaaag tctctttctc acttaccttt gcattcaaat aaagaagatg
      361 gctatgatgg cgttacatcg acagacaata tgagaaatgg attggttagc agtgaagtgc
      421 acaacgaaga cggaagaaat ggagatgtct ctcagttccc atatgtggaa tttactggaa
      481 gagatagtgt cacttgtccc acttgccaag gaacaggaag aattcctagg ggacaagaaa
      541 accaactggt ggcattgatt ccatatagtg atcagcggtt acggccaaga agaacaaagc
      601 tgtatgtgat ggcgtctgtg tttgtctgcc tgctcctgtc tggattggct gtgttttttc
      661 ttttccctcg atctattgag gtgaagtaca ttggagtaaa atcagcctat gtcagctacg
      721 acgctgaaaa gcgaaccata tatttaaata tcacgaacac actaaatata acaaataata
      781 actattattc tgttgaagtt gaaaacatca ctgctcaagt ccagttttca aaaaccgtga
      841 ttggaaaggc tcgtttaaac aacataacta acattggccc acttgatatg aagcagattg
      901 attatacggt acccacagtt attgcagagg aaatgagtta catgtatgat ttctgtacac
      961 tgctctccat caaagtgcac aacatagtac tcatgatgca agttactgta acaacagcat
     1021 actttggaca ctctgagcag atatctcagg aaaggtacca gtatgtcgac tgtggaagga
     1081 acacgactta ccagttggcc cagtctgagt atctaaatgt ccttcagcca caacaataaa
     1141 ctctaaagga gatgtggtta gagccgatga cacacctgag acatcgtcag aactgtcagt
     1201 gaggaggtac tgcctagaag gacatcttta attaagcacg tctgaagttc acactgggat
     1261 gtcgagggtc agctgacaga ctgtgggcct tgtgcagttc ctgcactctc actttctgtg
     1321 ttgacgattt gctcctacca agagcctttc gtccagctta agttaactga ttggctttct
     1381 tctcaccttt gttcccaagg tgaaaaattg aaacttccgt agaatacaat aaataattat
     1441 ataaaagtca tagatttaat ctatatatct attgataata tagttcattc ctgaacataa
     1501 tttgaaaaat aacttctgaa gatttttata taaaattact gaaagcctat tattcatgga
     1561 gaacttttaa aaactgacct gttttataaa ttcccattct tacatggtag tctttcaact
     1621 atatgataac ttagctatta gctaaatgtt tttagccttt aatttcttga aattctactg
     1681 atttgcatgt tttgtcttat ttctagctaa tggttgcata atatttacca accataccat
     1741 tcggccacat tctgttctac attttgtaag aacctctcag tatgtgtttc atgtataact
     1801 ttgtgagctt tctgtgtgat cttcaaacat attcctttaa tgtacaatat tgtaaataaa
     1861 gtgcatggct tttatacagc tttgataaag gtcaaatgaa gtagtacaga ttaagaataa
     1921 agcaggttgt tcataaacaa taaggtagga aattgaaatt aagaaaccta taaaatatca
     1981 gtaggttccg ctacatgttg gatctgacat aacatagatg cacagtaaaa catttcgatg
     2041 ctctactttt tatattaatt atatagatgc ttttcccagc aattaggtat catcaatttt
     2101 atgaatgttt tagggaagaa aaccatttct ttctagaaat tagtcaagga ataatttcat
     2161 tgaacactgg tgactacatc aaaataaaac ctatagtttg cttaaaaaat ttaatcatta
     2221 cccatcatcc tgagtcgatg cttctagcag ttacagtaaa catttatttt ttaattttgt
     2281 ctaacatggt tttcaaatat gatggacgta ttcatcttgt tgctttatat ttccagtgtc
     2341 atttttgacc aagtattttc cttattcacc cagcaaattt ccagtgcatt ctgttttctt
     2401 atgtcagaag ttgggttttc cgtttcccat acccaagtgc ttccgttggt tgtgatgtgt
     2461 gctctgttcc tcagcctggc tctcaagtgg aaagcagaaa ctctaacggc ttcaccctgc
     2521 ccttgaagca ctcgtcatct ttccttagca gtcacctgca ttcgctgtat gagggagctt
     2581 tggggtcacc cgtggtctgt gtgtggccac ccttcccgta cacccagagc accctctgca
     2641 gtcattcacg ctctagtcaa gctgggcttt gtttgtttgg tttttctttt ctgtgcttgc
     2701 tggtcacctc cattcttgaa gctgcacagt tggctggttg tgcttacatt tttcaaatca
     2761 acctcatttc attatatgca gtctctcctt tttatgtaac tgtctgtgag tcatttgttt
     2821 catttcattt gttttgtcta gaaatgtcta ctcctgttac ttaaaagtta ccactgtctt
     2881 tagtttggct actcagctga acactagcca taaatacgtg tgaggtgtgc aaaatcatca
     2941 tccatccatc tctgcagaat cgccctttac ctaggcctca tgtagtagcc actttctctg
     3001 ccccttccat gtgtatttca gtccaggaga gcactgtgtt ctgccagagt tcgtggacaa
     3061 ggcctactga ggcaggacag tacagtcaac tttactccca gtgattcagt ttcaaaaacc
     3121 ttttcgtaac tatttacatt gaaatttcta tctcaaccag ttctaatgtc tagctttaat
     3181 aatgcctgag tcatttgaaa acccagcctg caactcttca acgaaaatca agtaactcct
     3241 gggtaagcca ggctgctaac agctgtaagt taataaaact caaaccaaat gaacaaacag
     3301 cagctgaaca atagccatgg agacatctgc aactatgagt gaagctttgt gcttttctta
     3361 ggtctggttt agctaggtct gacttcgggc agggaggaag agtaggtatt aatatagttt
     3421 tatatgagca ccaccagagc ttagccaggg acatgatgaa gacattacca tgttgcccca
     3481 tgctcacagg ggtaaattct gttctacact aacccagcac tgccccaggc tctgtgtgga
     3541 caacacactg gctgttgctc ttctgtctgc ttttcttatg taatttctca acaggacact
     3601 gggaggattt ggtttaaaat tatatattag taaatccttc agttgcagcc agaagctgct
     3661 tctccgactc tcttcttatc tgtgccctat caattacaat gtccattggc aagccatggt
     3721 gactcaggtt agtacaatta cacattgaaa aagtggccgg caaggtgggg cagcggttga
     3781 ggatggtggc caccaagctt gatgacctga gttcaatctt tgtaccccac agaaggcgga
     3841 gagaactggc actcttctcg gatgaccgtt cacggacagt acaataccac atatatagtg
     3901 tacacacaca tacaaatgtg tcgatgccca ttcacaaaca gtacagtaca cgcacacaca
     3961 gacacataca aatgcatgaa aaaataaagt aaaagttttt gaagttaata gtgatggcta
     4021 agattttggt agctttgagt tgctatctga aatatttcta aaagtaaatt aaacgatgta
     4081 gaatccttca gaaccaaagc tggagcttaa tttttatgtg ttaatattta atacttcaca
     4141 atcattccaa taaaaataaa actgacattt ttggtgtgaa ttatttataa gtaagattat
     4201 tacatttgag atttgaaata cagagctgaa aatactagac atgagataaa tttcttgaaa
     4261 ttgcttgaaa gactatcttg cctgaggtga catttcatag aacataactg tattttgtta
     4321 tcagttttcc tttgactcct gtttacccgg tcttaatgaa gtaattcttt tttcttaaaa
     4381 cctattaaaa gagtaaaata taactgactt cagatcttat aatttgcact taggaaatgg
     4441 tggtgaagtg taaaaggatg tgggaggttg acatccaaac accgtctaag taacattagg
     4501 acaattggaa cttggcccta atgggccttg tggtttttag cctactatgg aataattttg
     4561 gctattatgt tggcaggtgt gccgactttt ccattctgcc ttttaaagtg cttaaatcaa
     4621 ctggttgtta acacattgcg tcttatttta gaagatagtt tcattcatat gtttttaaaa
     4681 taggagtacc ttttacattt tcaaatacat ttttgtcttc tttgataagt aataagagct
     4741 aaacatttag ccattggttt ataatcaaat ggtaaaccgt gatgcctgag acactaaaat
     4801 gccatagctg cttggctcaa agtgtgtctt agagtgggca gccttattcc tctgactttg
     4861 tgaaactaga ttttaaatga aacatttatc tttaactttc taaagaaaat tagtacatat
     4921 cttagaaagc tgaataaaaa aaatcactat ttcttcaaag ttgtaatttt agattaaaat
     4981 aaatgtattt gtgatatact tacttggctc aaaaatttaa cttctatatc aaagacctat
     5041 ttacattaca gtcttcattc acagtttctg gttgcaacta ctttgtgtgg tttttagctt
     5101 gcttagagaa caggtttcac agaagagctc tgacgcttat ctttaaattc gataaaagca
     5161 acagcaatgg gattactgta ggaacacaaa tagaatttcc atgttttaag ctgttcttgt
     5221 tcctttttac atgtgttaac acagactcca agctgaagat acagtgtggt tggggttcaa
     5281 ccctcaaagc agtgcataga caacgtagca atattatgag gagcttcata gttaagtctt
     5341 aactattcta gaaggaagtt gttgccttct gtttaattac attcatgaaa tgtgtttaag
     5401 tgaaatattt tcaggatatt ttgtatgctg taaaacaaaa aaggaattgt attgtgccaa
     5461 tggccaaagg taatattact accatgtaga tgatgacagt tcaaattgtc ccacgtcacc
     5521 cagaagttta gaaactagaa gtctgggaga caccacatca gttgtattgg gtgattctta
     5581 agtgctgtac acgctattca tcttgtcaat gtccagcaca agaaggagcg atgccaggca
     5641 agctgcaaag atgcagaatt tcatgacgca ggctggtgtc agacataagt atcagccagt
     5701 catgtccgtg tgttttatct tagagtttca cttagagctt cacccttaag agttggaaaa
     5761 tgatttggga tgtgatagta ttcctaagct ctgacagtcg attcggatgg tggaatagag
     5821 aatgtaaggt ccgttctgta tgcttgctct ttagcgacct ccattatgtt acatctgtta
     5881 aattcattat ttgtacagtt ctgaattatt atgattgctg ttcatgtagg gaaacatggt
     5941 tatgatagga acaagaatag aaatgtcccc aatgctattt tttaaattca cttgtaactg
     6001 ttactcttat acttgtgtat gacaaaataa aatttgtaaa aaacacttta gcatgaaaaa
     6061 taaaatttgt atcaacaaag taaaaaaaaa aaaaaaaaa
//
