LOCUS       NM_144830               2301 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus transmembrane protein 106A (Tmem106a), transcript
            variant 3, mRNA.
ACCESSION   NM_144830
VERSION     NM_144830.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   Zhang,X., Feng,T., Zhou,X., Sullivan,P.M., Hu,F., Lou,Y., Yu,J.,
            Feng,J., Liu,H. and Chen,Y.
  TITLE     Inactivation of TMEM106A promotes lipopolysaccharide-induced
            inflammation via the MAPK and NF-kappaB signaling pathways in
            macrophages
  JOURNAL   Clin Exp Immunol 203 (1), 125-136 (2021)
   PUBMED   33006758
  REMARK    GeneRIF: Inactivation of TMEM106A promotes
            lipopolysaccharide-induced inflammation via the MAPK and NF-kappaB
            signaling pathways in macrophages.
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Dai,H., Xu,D., Su,J., Jang,J. and Chen,Y.
  TITLE     Transmembrane protein 106a activates mouse peritoneal macrophages
            via the MAPK and NF-kappaB signaling pathways
  JOURNAL   Sci Rep 5, 12461 (2015)
   PUBMED   26215746
  REMARK    GeneRIF: data suggest that mouse Tmem106a might be a new trigger of
            macrophage activation and have some influence toward the M1 state
            through the activation of the MAPKs and NF-kappaB pathway
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2301)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146019.1.
            
            On Apr 5, 2007 this sequence version replaced NM_144830.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1 through 4 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146019.1, AK154217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2301              AK146019.1         2-2302
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.44 cM"
     gene            1..2301
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /note="transmembrane protein 106A"
                     /db_xref="GeneID:217203"
                     /db_xref="MGI:MGI:1922056"
     exon            1..84
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            85..164
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            165..391
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..969
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /codon_start=1
                     /product="transmembrane protein 106A"
                     /protein_id="NP_659079.1"
                     /db_xref="CCDS:CCDS25476.1"
                     /db_xref="GeneID:217203"
                     /db_xref="MGI:MGI:1922056"
                     /translation="MGKAVSQLTSRKDEDKPILPDNPAMASQAANYFSTGSSKPAHSC
                     MPYEKAASSSFVTCPTCQGNGEIPQEQEKQLVALIPYGDQRLKPRRTKLFVFLSVAIC
                     LLIFSLTIFFLYPRPIAVRPVGLNSSTVTFEDAHVQLNTTNVLNIFNSNFYPITVTQL
                     TAEVLHQASVVGQVTSSLRLHIGPLASEQMPYEVASRILDENTYKICTWPKIRVHHIL
                     LNIQGSLTCSFLSHPQQLPFESFEYVDCRENMSLPHLELPRPA"
     exon            392..455
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..609
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..750
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            751..794
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..848
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            849..2301
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1428
                     /gene="Tmem106a"
                     /gene_synonym="0610008L10Rik"
ORIGIN      
        1 ggggccgagc ccggcttgga ctccgagctt gtgttaaatg tgcagctccc gcagtttcga
       61 ttttgctgag ggcgttgtca cctgaggccc ttctccccaa aggagcattc cagaaaaccc
      121 aatcttggag ctgagcagag cctggaatcc cagacctaaa ccagtgaaaa attccgctgg
      181 actatgggta aggcagtctc ccagctcacc tctcggaagg atgaggacaa gcctatccta
      241 cctgataacc cagccatggc cagccaggct gccaactact tcagcactgg tagcagcaag
      301 ccagcacact cctgtatgcc ttatgaaaag gctgctagtt ccagctttgt gacttgtcct
      361 acctgccaag gcaatgggga gatcccccaa gagcaagaga agcagctggt tgctctcatc
      421 ccttatggag accaaaggct gaagcccaga cgcacgaagc tctttgtgtt cctgtcggtg
      481 gccatctgcc tgctgatttt ctccctcacc atctttttcc tgtatccccg gcccattgct
      541 gtgcgtcctg tcggcctcaa ctcttccaca gtaacctttg aagacgctca cgtacagctc
      601 aacacgacga atgtcctgaa catcttcaac agcaacttct atcccatcac agtgacacag
      661 ctgacggccg aggtgctcca ccaggcctct gtggtaggcc aggtcaccag cagcctccgc
      721 ctgcacatcg gcccattggc cagtgagcag atgccttacg aagttgccag caggattttg
      781 gatgaaaaca catacaaaat ctgtacatgg ccgaaaatca gagtccacca tattcttttg
      841 aatatccagg gttctctgac ctgctccttc ctaagccatc cgcaacagct gcccttcgag
      901 agctttgaat atgtagactg cagagaaaac atgtccctgc cccacctgga gctgccccgc
      961 ccagcctgat ctgtctgccg cccctggact ccaggcacct gcaagctgat ctgcagctca
     1021 gctccgtgga gctcaaggaa agactgtagg gactttgttg aaggaaaagt cctgctttgg
     1081 gccctgcctt cccctaacac cctcagcaca cagagcttct gtaacaatgt catagtccct
     1141 gagtcctcag acctccccac tcccccacga gtcgcttctg atggatctta cccatggtct
     1201 gtgtggggag gaacggctac cttggcgttg tcttgggact gagcatgttg gttacccagc
     1261 tccgccaggg tgggtcttca atcgcaacga agagaaagct gtagttttat ctagactttg
     1321 cagcatggat gaatcttttt caagctctcc tcccagtaat aagtggcttt ggggatatcc
     1381 agtgctgttt ccaaggtctc cttgggtgac tataaatgtt ctcctgtact gtcttgcttt
     1441 gatcatgtga taatgagggt aatagactac ttctctcagt aaatggtaga caataaggtc
     1501 ctcatcctcc caggttcgga atactatccc tggcttccag gaagggagat ttacaccatc
     1561 taaactcttc tctatagact ggctccaatg ctatcttcac agcagaaacc aaggagctga
     1621 ggagaaacca tcgggtgtac cctagagcaa aggcagagcc agttgcaaag atatttatta
     1681 aaggaaagtt tctaagccca ccatccagag cccatgtgag tgcacacagg taagacaggc
     1741 agtagagcag gcccaggggc agtgttcaga aagcatgaag gacataagct gttgatacca
     1801 ggccaaagct gtggggctct catggattct ctgcatcagg cccaccctct gctgtcctct
     1861 gggatgtgac tgaagagtga cagattcacc agaatttcct tccttgcctg tcactacact
     1921 gacgccaaac cacaggtaac ccccagtttt ctactggact ccaggtggag atatgatgtc
     1981 tgttgccgga gagcagaaat gtgtgttctc taaagctagc tagcctctgc cctccagaca
     2041 ggtgcaaagg cgaagggcgg tgtggttggg gaaaattgaa tttgaagtga gaagaatgca
     2101 aggaaatggt ggtaactgag ctgggtaact agcctggggc tacacagagg gagaggaagt
     2161 cttgtctgca ccaagttttc cctcctgggt agccagggct aaggtgtaca aaccaaagga
     2221 gacccaggga agtcaagctg agattagagt gtataaacca tcaaatgtaa aagatttcta
     2281 acaataaatt gttctttagc c
//
