LOCUS       NM_019790               3339 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus transmembrane protein with EGF-like and two
            follistatin-like domains 2 (Tmeff2), mRNA.
ACCESSION   NM_019790
VERSION     NM_019790.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3339)
  AUTHORS   Kaiser,M., Wojahn,I., Rudat,C., Ludtke,T.H., Christoffels,V.M.,
            Moon,A., Kispert,A. and Trowe,M.O.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   2  (bases 1 to 3339)
  AUTHORS   Huang,H., Teng,P., Mei,R., Yang,A., Zhang,Z., Zhao,X. and Qiu,M.
  TITLE     Tmeff2 is expressed in differentiating oligodendrocytes but
            dispensable for their differentiation in vivo
  JOURNAL   Sci Rep 7 (1), 337 (2017)
   PUBMED   28336932
  REMARK    GeneRIF: Together, these data suggested that Tmeff2 is specifically
            upregulated in oligodendrocytes, but dispensable for
            oligodendrocyte differentiation and maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3339)
  AUTHORS   Hong,H.S., Maezawa,I., Petrlova,J., Zhao,X.Y., C Voss,J. and
            Jin,L.W.
  TITLE     Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-beta (Abeta)
            Oligomer and AbetaPP and Protects Neurons from Abeta-Induced
            Toxicity
  JOURNAL   J Alzheimers Dis 48 (3), 731-743 (2015)
   PUBMED   26402097
  REMARK    GeneRIF: Results suggest that TMEFF2 is a brain-enriched endogenous
            modulator of Abeta neurotoxicity and an enhancer of alpha-secretase
            processing of AbetaPP
REFERENCE   4  (bases 1 to 3339)
  AUTHORS   Chen,X., Corbin,J.M., Tipton,G.J., Yang,L.V., Asch,A.S. and
            Ruiz-Echevarria,M.J.
  TITLE     The TMEFF2 tumor suppressor modulates integrin expression, RhoA
            activation and migration of prostate cancer cells
  JOURNAL   Biochim Biophys Acta 1843 (6), 1216-1224 (2014)
   PUBMED   24632071
  REMARK    GeneRIF: Loss of TMEFF2 is associated with cell migration and
            invasion leading to prostate cancer.
REFERENCE   5  (bases 1 to 3339)
  AUTHORS   Chen,T.R., Wang,P., Carroll,L.K., Zhang,Y.J., Han,B.X. and Wang,F.
  TITLE     Generation and characterization of Tmeff2 mutant mice
  JOURNAL   Biochem Biophys Res Commun 425 (2), 189-194 (2012)
   PUBMED   22828515
REFERENCE   6  (bases 1 to 3339)
  AUTHORS   Hodge,L.K., Klassen,M.P., Han,B.X., Yiu,G., Hurrell,J., Howell,A.,
            Rousseau,G., Lemaigre,F., Tessier-Lavigne,M. and Wang,F.
  TITLE     Retrograde BMP signaling regulates trigeminal sensory neuron
            identities and the formation of precise face maps
  JOURNAL   Neuron 55 (4), 572-586 (2007)
   PUBMED   17698011
REFERENCE   7  (bases 1 to 3339)
  AUTHORS   Heanue,T.A. and Pachnis,V.
  TITLE     Expression profiling the developing mammalian enteric nervous
            system identifies marker and candidate Hirschsprung disease genes
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 6919-6924 (2006)
   PUBMED   16632597
REFERENCE   8  (bases 1 to 3339)
  AUTHORS   Assimacopoulos,S., Grove,E.A. and Ragsdale,C.W.
  TITLE     Identification of a Pax6-dependent epidermal growth factor family
            signaling source at the lateral edge of the embryonic cerebral
            cortex
  JOURNAL   J Neurosci 23 (16), 6399-6403 (2003)
   PUBMED   12878679
REFERENCE   9  (bases 1 to 3339)
  AUTHORS   Horie,M., Mitsumoto,Y., Kyushiki,H., Kanemoto,N., Watanabe,A.,
            Taniguchi,Y., Nishino,N., Okamoto,T., Kondo,M., Mori,T.,
            Noguchi,K., Nakamura,Y., Takahashi,Ei. and Tanigami,A.
  TITLE     Identification and characterization of TMEFF2, a novel survival
            factor for hippocampal and mesencephalic neurons
  JOURNAL   Genomics 67 (2), 146-152 (2000)
   PUBMED   10903839
REFERENCE   10 (bases 1 to 3339)
  AUTHORS   Uchida,T., Wada,K., Akamatsu,T., Yonezawa,M., Noguchi,H.,
            Mizoguchi,A., Kasuga,M. and Sakamoto,C.
  TITLE     A novel epidermal growth factor-like molecule containing two
            follistatin modules stimulates tyrosine phosphorylation of erbB-4
            in MKN28 gastric cancer cells
  JOURNAL   Biochem Biophys Res Commun 266 (2), 593-602 (1999)
   PUBMED   10600548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029307.1.
            
            On May 7, 2009 this sequence version replaced NM_019790.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029307.1, SRR1660815.72825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2347              AK029307.1         1-2347
            2348-3339           AK029307.1         2349-3340
FEATURES             Location/Qualifiers
     source          1..3339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 25.95 cM"
     gene            1..3339
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="transmembrane protein with EGF-like and two
                     follistatin-like domains 2"
                     /db_xref="GeneID:56363"
                     /db_xref="MGI:MGI:1861735"
     exon            1..597
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1550
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="tomoregulin-2"
                     /codon_start=1
                     /product="tomoregulin-2 precursor"
                     /protein_id="NP_062764.1"
                     /db_xref="CCDS:CCDS14939.1"
                     /db_xref="GeneID:56363"
                     /db_xref="MGI:MGI:1861735"
                     /translation="MVLWESPRQCSSWTLCEGFCWLLLLPVTLLIIARPVKLAAFPTS
                     LSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNSDYVPV
                     CGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDTGSGSGDGVHEGSGETSQKETS
                     TCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEK
                     IEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHG
                     KCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVI
                     CVVVLCITRKCPRSNRIHRQKQNTGHYSSDNTTRASTRLI"
     exon            598..707
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..837
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..864
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..961
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1110
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1170
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1294
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1453
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..3339
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="hexamer: AATAAA"
     polyA_site      1781
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="major polyA site"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="hexamer: AATAAA"
     polyA_site      1842
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
     regulatory      2780..2785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="hexamer: AATAAA"
     polyA_site      2806
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
     regulatory      2951..2956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="Tmeff2"
                     /gene_synonym="4832418D20Rik; 7630402F16Rik; TR-2"
ORIGIN      
        1 ggatgcgggc ggcagagcgc gagaggcggc ggctgggctg cggggcgctg tgactgtccc
       61 tccacccagt ctggtcgcgc tcttctcttc ggccgattgg ccgcctcctc tccgcaccct
      121 ggtttctgtc tcctgctcct cctttgcccc gaccctgttc cttatggcag cagctccttg
      181 catcgggggc gcagcttctc agcggactat cctctcactc cgcaggctga gcccggtcac
      241 tggatgttgc tgaaactccg gagatcatgc tctcctttgg tcgcagtatc accgccggct
      301 gtccctgccg ccgccccctc ctctgctgcc gcggtccgcg ggatgctcag tagcccgctg
      361 cgtggcccct gcgatcccgt gttcttcaga agcctttggt tgctgcagag ttgcgcgaag
      421 tagtcatggt gctgtgggag tccccgcggc agtgcagcag ctggacactt tgcgagggct
      481 tctgctggct gctgctgctg cccgtgacgc tgcttatcat agcccgcccg gtaaaactcg
      541 ctgctttccc tacctcctta agtgactgcc aaacgcccac cggctggaac tgctccggtt
      601 acgatgacag agaaaatgat ctcttcctgt gtgacaccaa cacctgtaaa tttgacgggg
      661 aatgtttaag gattggagac actgtgactt gcgtctgtca gttcaagtgt aacagtgact
      721 acgtgcctgt gtgtggctcc aatggagaga gctaccagaa tgagtgctac ctgaggcaag
      781 ctgcctgcaa acagcagagt gagatacttg tggtctcaga aggatcctgt gctacagata
      841 caggatcggg atctggagat ggagtccatg aaggctctgg cgagaccagt cagaaggaga
      901 catccacctg tgacatttgc cagtttgggg cagagtgtga tgaagatgct gaggatgtct
      961 ggtgtgtgtg caacatagac tgttctcaaa ccaacttcaa tcccctctgt gcttctgatg
     1021 ggaaatctta tgataatgca tgtcaaatca aagaagcgtc atgtcagaaa caggagaaaa
     1081 ttgaagtcat gtctctgggt cgatgtcaag ataacacaac tacaaccact aaatctgaag
     1141 atgggcatta tgcaagaaca gattatgcag agaatgctaa caaattagaa gaaagtgcca
     1201 gagaacacca cataccttgc ccagaacatt ataatggttt ctgcatgcat gggaagtgtg
     1261 aacactccat caatatgcag gagccatctt gcagatgcga tgctggttac actggtcaac
     1321 actgtgaaaa gaaggactac agtgttctct acgttgttcc tggccctgtc cggttccagt
     1381 acgtcttgat tgcagctgtg attggaacaa ttcagattgc tgtcatctgc gtggtggtcc
     1441 tctgcatcac aaggaaatgc cccagaagca acagaattca cagacagaag caaaatacag
     1501 ggcactacag ttcagacaac acaacaagag catccacacg gttaatctag agggagcatg
     1561 tttcccagtg gccggacaac caacagcttg gactacacaa tacagtatta gagacaaaag
     1621 aataagacaa gatctacaca tgttgccttg cgtttgtggt aatctacacc aatgaaaaca
     1681 tgtactacag ctatatttga ttatgtatgg atatatttga aatagtatac attgtcttga
     1741 tgttttttct gtaatgtaaa taaactattt atatcacaca atatagtttt ttctttccca
     1801 tgtatttgtt atatataata aatactcagt gatgagaaca aatggcattc ctaaacttgc
     1861 agtaattcat agctgtaagc acggtccaac tgtcatgggc tacgcagaca gcagtatttc
     1921 atccctctgt gcatcttcag acaacacatt agtttgcaca ggaatctgta gctagatttt
     1981 gagtgattcc aagatcaagg gatataccgg ttattggaaa agagaaaaaa taatttagtt
     2041 tattgaggaa gcataagata tgtcatatcc ttgaatcatc tctgcttcat ctactttctt
     2101 ccctgtcttt cattgtcatt cccagaacag aaaaatctct ggcatataag ttacaaaagg
     2161 gaagaatgga agtgttttgt ggctcaaaat aaaatgcaaa aaaaagatat ttgtctttac
     2221 tgagaagcaa cataactatc ttagttaaat aatctaccag ggggcggggt ctgagaaagg
     2281 tatccactag gtgtataaac agtggtcaaa cctattctgt ttctgtttct gcaagcagaa
     2341 aaaaaaagct aagagtacat tgtaactgtg tcagtaagta tgagcccaaa ctgtggcttc
     2401 ttagaagacc cttgctgtat ttgtatctta tttgaaaaga atttagacta ccaaacaaat
     2461 gcccccacga acagttttat agcccaaaga gtactgttat ttgaaactga aaaacaaaaa
     2521 gacaatgttt tatggtaatg gagagagata agttttaaac gtatttacat aagaaagaaa
     2581 atccctaaga atctagagga cctccatgag agctgctttc aacccctatg agatacgagc
     2641 agacaggtat gaatggtcac attgcttggg gaaagtaagt tgagaacatt ctcaaggaat
     2701 aagatgaaat acccaattaa ataatctcct tattatcatt tacctctgag tagtttctgt
     2761 ggcacatgtg gatgatttaa ataaagcttt atttgtcttc ctcaaatgac ttcttcatgg
     2821 actaaaagaa atggcatccc ctcctttgtt agaaaccaaa aaacacatag caatccaaaa
     2881 tgttctgaat ataaaatatt atatgaaaaa taagggtctg aggtgaaatt taaactacct
     2941 gttaatatat aataaaggtg acaatctaca taagacttag gactttgaaa actgtgtttt
     3001 tctaaattaa gtcataaatt tgaaaatttg atataaccat catgcaagtg ttgctatgaa
     3061 tcactctctt gatagataga tatgacaaat ccctgctaat ctgtgtgtgt aatttgttta
     3121 acatgcacag agatgtaagt ggccctagta ttctttatat gttaataact atagcaaata
     3181 aatcctttct tcttccaaaa gaagaaggga aaatgtacta ttcctagtga ggcataggtt
     3241 taaagtaaca atttcactga cctttgcttt caaaaatatg aactgactga ttttgttcca
     3301 tgtttactta tcactctata taaattttta ttcaagatc
//
