LOCUS       NM_001356272            2484 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus transmembrane protein with EGF-like and two
            follistatin-like domains 1 (Tmeff1), transcript variant 1, mRNA.
ACCESSION   NM_001356272 XM_006537836
VERSION     NM_001356272.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Xie B, Zhang J, Ma C, Yu H, Ni Z, Cong B and Wen D.
  TITLE     Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus
            Accumbens During Incubation of Morphine Craving
  JOURNAL   Int J Neuropsychopharmacol 25 (5), 412-424 (2022)
   PUBMED   35020881
  REMARK    GeneRIF: Roles of miR-592-3p and Its Target Gene, TMEFF1, in the
            Nucleus Accumbens During Incubation of Morphine Craving.
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   Bao D, Lu D, Liu N, Dong W, Lu YD, Qin C and Zhang LF.
  TITLE     Tomoregulin-1 prevents cardiac hypertrophy after pressure overload
            in mice by inhibiting TAK1-JNK pathways
  JOURNAL   Dis Model Mech 8 (8), 795-804 (2015)
   PUBMED   26092120
  REMARK    GeneRIF: A possible mechanism by which tomoregulin-1 regulates the
            development of cardiac hypertrophy in TAC-induced cardiac
            hypertrophy is through inhibiting TGFbeta non-canonical (TAK1-JNK)
            pathways in the myocardium.
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Arano T, Fujisaki S and Ikemoto MJ.
  TITLE     Identification of tomoregulin-1 as a novel addicsin-associated
            factor
  JOURNAL   Neurochem Int 71, 22-35 (2014)
   PUBMED   24680664
  REMARK    GeneRIF: The double-fluorescent immunohistochemical analysis
            revealed that addicsin and tomoregulin-1 were coexpressed in
            neurons
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Morais da Silva S, Gates PB, Eib DW, Martens GJ and Brockes JP.
  TITLE     The expression pattern of tomoregulin-1 in urodele limb
            regeneration and mouse limb development
  JOURNAL   Mech Dev 104 (1-2), 125-128 (2001)
   PUBMED   11404089
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Eib DW, Holling TM, Zwijsen A, Dewulf N, de Groot E, van den
            Eijnden-van Raaij AJ, Huylebroeck D and Martens GJ.
  TITLE     Expression of the follistatin/EGF-containing transmembrane protein
            M7365 (tomoregulin-1) during mouse development
  JOURNAL   Mech Dev 97 (1-2), 167-171 (2000)
   PUBMED   11025219
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   De Groot E, Feijen A, Eib D, Zwijsen A, Sugino H, Martens G and Van
            Den Eijnden-Van Raaij AJ.
  TITLE     Expression patterns of follistatin and two follistatin-related
            proteins during mouse development
  JOURNAL   Int J Dev Biol 44 (3), 327-330 (2000)
   PUBMED   10853830
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619168.1, CF532023.1, CN534217.1, BU709349.1, BM947087.1 and
            BC057598.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001356272.2.
            
            On Sep 28, 2017 this sequence version replaced XM_006537836.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.62375.1,
                                           SRR1660817.27830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BB619168.1         2-15
            15-587              CF532023.1         1-573
            588-1050            CN534217.1         32-494
            1051-1299           BU709349.1         357-605
            1300-1735           BM947087.1         220-655
            1736-2484           BC057598.1         1714-2462
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.15 cM"
     gene            1..2484
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /note="transmembrane protein with EGF-like and two
                     follistatin-like domains 1"
                     /db_xref="GeneID:230157"
                     /db_xref="MGI:MGI:1926810"
     exon            1..468
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1418
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tomoregulin-1; transmembrane protein with
                     EGF-like and one follistatin-like domain"
                     /codon_start=1
                     /product="tomoregulin-1 isoform 1 precursor"
                     /protein_id="NP_001343201.1"
                     /db_xref="GeneID:230157"
                     /db_xref="MGI:MGI:1926810"
                     /translation="MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSRASNQPAGGG
                     GDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPV
                     CGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGAEEEGSGAGAHRKH
                     SKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQE
                     QIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYC
                     IHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQI
                     AIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV"
     exon            469..578
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..708
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..735
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..835
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..984
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1050
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1174
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1333
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..2464
                     /gene="Tmeff1"
                     /gene_synonym="A830033E11; M7365; TR-1; Tr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacacaaag ggaaggcgag cctgcgagct agaagctgcg tccgtccccg ccccgcgccc
       61 cccgcgcgcg ccccagctcc gtgttcccca cgcggcgcgc tccctgccct cgcgcgcccg
      121 cgcccctcgc ccgcgccggg gtctcccaac gaggctgtcc cgagcgcgga gggccggggc
      181 ctggcgggga tgctgcgggg ctgccccggg cggctgcacg gctgctagga ggcggcgcgg
      241 ggccggtgtg cccggcctgc cgctccctga gctccccgcc gtgcggccgc gacagcatgg
      301 gcgcccaggc gccgctccgg ctgccggccg cgcccccgct cgccgtctgc ggctacacgt
      361 cggtgcttct gctcttcgcc ttctgcctgc ccgggagccg cgcgtccaac cagcccgcgg
      421 gcggcggcgg ggactgtccg ggaggcagag gcaagagcaa ctgctcagaa ttaaatctga
      481 gagaatctga catcagagtg tgtgatgaat catcttgtaa atatggaggt gtctgcaaag
      541 aagatggaga tggtttgaaa tgcgcatgcc agtttcagtg ccatacaaat tacatccctg
      601 tctgtgggtc aaacggggac acctaccaga atgagtgctt tctcaggagg gctgcttgca
      661 agcaccagaa agacataacc gtggtggcgc gtggaccttg ctactctgat aacggctctg
      721 gatctggaga aggagcagag gaggaaggct caggagcagg ggctcacagg aaacattcca
      781 agtgtggacc gtgcaagtac aaggccgagt gtgacgagga tgcggagaac gttgggtgtg
      841 tatgtaatat agactgcagt gggtacagct ttaaccctgt gtgcgcttcc gacgggagtt
      901 cctataacaa tccctgtttc gtccgagaag cgtcgtgtat aaagcaagaa cagatcgaca
      961 taaggcatct cggccactgc acagacacag atgatgtgag tttattggga aagaaggacg
     1021 acgggctgca gtatcggcca gatgtgaaag atgcaggtga tgaaagggaa gatgtttata
     1081 tcggaagcca catgccttgc cctgaaaacc tcaatgggta ctgcatccat gggaaatgtg
     1141 aattcatcta ctctactcag aaggcctctt gtagatgtga atctggttac actggacagc
     1201 actgtgagaa gacggacttt agtattctct atgtagtacc aagtaggcag aagctcaccc
     1261 atgttcttat cgcagccatt attggagcag tacagatcgc cattatagta gcaatcgtca
     1321 tgtgcataac aaggaaatgc cccaagaaca atagagggcg gaggcagaag cagaacctgg
     1381 gtcattttac ttcagacact tcatccagaa tggtctgagc cgcggacttt tatatgcgca
     1441 ctgaccacgt gatgtacatt tattatgtct ttttttaaag aatggaaata tttatttcag
     1501 aggccttatt tttggacatt tttagtgtag tactgttggc tcgtatttag aatatttagc
     1561 tacaacagtt tttgactgtt tagtagtctc tgttttatgt ttttaaatac agaaattggc
     1621 ttcacgaatt tgtaacacat ggtgatacta ctaagacttg ttctttatcc atggaatgta
     1681 atatttttgc agagacggat ggacccactt cacggtggtc ataaagtcat acttcttccc
     1741 cagtgaccac agcaaatgac aaagcatgaa ctaaagtaaa gatgtttaca gattactttt
     1801 cttacaaaaa aaatctagag gacactgtgt ttaaatagat atttaaatgc ttttgaggtt
     1861 tagtatctga ttttttttag acacttcccc tattgcatgg gctgccaagc tgtgtgtatg
     1921 tgttagatgt cacatattta taagctgtac aaactgcagt tgactatttc tctccttgaa
     1981 gaaataatcc taatcatttt aaaaggggcc tgggaattaa cggtggaaca ggtcactgaa
     2041 aataggttta gatattgtca agatagggcg tttaatgagc agattgcaat aaaacctaca
     2101 gtatcagcta aactacttta atacacattc atttttaaac attgtatttg ttttaatata
     2161 aatgtacaaa ttatatcagt gtttgtgaat acaatgcaga aataattgtt aatgattggt
     2221 gctctgaaag tgagcttaaa aatgacctaa gacctctaat tcaaatctgt cctgtagtag
     2281 ctctattaat agatcgttgg tgtttcaaag tctgaactgt gagtagaatg tatcgaggcg
     2341 tttaacatgt agtttagcca gtcaaaagta tgcatgtaga gtttaaagac tatgtttaaa
     2401 cttaaatatt aattttaata atttgatttg gaaaagcatg ttataatata atgttttcac
     2461 tataaaaaaa aaaaaaaaaa aaaa
//
