LOCUS       NM_025458                863 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane p24 trafficking protein 6 (Tmed6), mRNA.
ACCESSION   NM_025458 XM_914060
VERSION     NM_025458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 863)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 863)
  AUTHORS   Wang,X., Yang,R., Jadhao,S.B., Yu,D., Hu,H., Glynn-Cunningham,N.,
            Sztalryd,C., Silver,K.D. and Gong,D.W.
  TITLE     Transmembrane emp24 protein transport domain 6 is selectively
            expressed in pancreatic islets and implicated in insulin secretion
            and diabetes
  JOURNAL   Pancreas 41 (1), 10-14 (2012)
   PUBMED   22129529
  REMARK    GeneRIF: Data show that TMED6 mRNA is highly and selectively
            expressed in pancreas,and knockdown of TMED6 gene expression in
            Min6 beta cells decreased insulin secretion.
REFERENCE   3  (bases 1 to 863)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007885.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025458.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086923.1, AK007885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               AK007885.1         2-864
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.58 cM"
     gene            1..863
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /note="transmembrane p24 trafficking protein 6"
                     /db_xref="GeneID:66269"
                     /db_xref="MGI:MGI:1913519"
     exon            1..246
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..753
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /note="transmembrane emp24 domain-containing protein 6;
                     p24gamma5; p24 family protein gamma-5; transmembrane emp24
                     protein transport domain containing 6"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 6
                     precursor"
                     /protein_id="NP_079734.1"
                     /db_xref="CCDS:CCDS22645.1"
                     /db_xref="GeneID:66269"
                     /db_xref="MGI:MGI:1913519"
                     /translation="MFPLLLVAELVVLSLVTSVKSQETDPLHGSKDQPLFRGADRNDF
                     AIVVSPGAIECFWQFADQMGYLYFSYEVQRILGMSHDRHIVATAHTPQGFLIDTSQDV
                     RGQINFATQETGFYQLCLKNEQNRFSSIQVYLNFGVFYEGPEVDHKQSQRKQLNDTLD
                     AIKDSTQRVENQVFHMWRFYNYARMRKVADFFLLQSNYTYVNWWSTAQSLAIVLSGAL
                     QLYFLKRLFTASTTDTKKPRC"
     exon            247..373
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            374..522
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            523..863
                     /gene="Tmed6"
                     /gene_synonym="1810015P03Rik; 1810018I24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcacctg cagaagaacc cacagaaggc agcatgttcc ctttgctcct cgtggctgag
       61 ctggtagttc tgagcctcgt gacttctgtt aagagccagg agacagatcc cctacacggc
      121 tccaaggacc agccactctt ccgtggagct gatcggaatg actttgccat cgtggtctct
      181 ccaggagcca tcgaatgttt ctggcaattt gctgaccaga tgggatacct ctacttcagc
      241 tacgaggttc agcgcattct cgggatgtca catgaccgcc acattgttgc cacggcacat
      301 accccgcagg gtttccttat tgacacttcc caggatgtaa ggggccagat taactttgct
      361 acacaagaaa caggcttcta tcagctttgt ctaaaaaatg agcagaatcg cttcagttct
      421 atacaagtgt atctcaactt cggagtcttc tatgaggggc ccgaggtgga tcacaagcag
      481 agtcaaagga agcaactgaa cgacactctg gatgcgatta aggacagcac acaaagggtg
      541 gagaaccaag ttttccacat gtggcgcttc tacaactatg ccaggatgag aaaagtggct
      601 gacttcttcc tcctgcagtc taactacacc tatgtgaact ggtggtccac agctcagagc
      661 cttgctattg ttctttccgg ggccctccag ctctatttct tgaaaagact ttttactgct
      721 tcaactactg acacaaagaa gccaagatgc taacatatag cctatttgtc aaagctttga
      781 tcaaatgggc tttggaaagt tattgggggg ggggtcaact tatgtcccct ttctcttgtg
      841 tccaccaata aaggcaaatg ttt
//
