LOCUS       NM_134020               1645 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane p24 trafficking protein 4 (Tmed4), mRNA.
ACCESSION   NM_134020
VERSION     NM_134020.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Hwang,S.O., Boswell,S.A., Seo,J.S. and Lee,S.W.
  TITLE     Novel oxidative stress-responsive gene ERS25 functions as a
            regulator of the heat-shock and cell death response
  JOURNAL   J Biol Chem 283 (19), 13063-13069 (2008)
   PUBMED   18326488
  REMARK    GeneRIF: ERS25 may play a critical role in regulation of heat-shock
            response and apoptosis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC023041.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023041.1, SRR1660811.8902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.94 cM"
     gene            1..1645
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /note="transmembrane p24 trafficking protein 4"
                     /db_xref="GeneID:103694"
                     /db_xref="MGI:MGI:1915070"
     exon            1..164
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..688
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /note="transmembrane emp24 domain-containing protein 4;
                     p26; ERS25; endoplasmic reticulum stress-response protein
                     25; p24alpha3; p24 family protein alpha-3; transmembrane
                     emp24 protein transport domain containing 4"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 4
                     precursor"
                     /protein_id="NP_598781.1"
                     /db_xref="CCDS:CCDS24415.1"
                     /db_xref="GeneID:103694"
                     /db_xref="MGI:MGI:1915070"
                     /translation="MAGVGVGPLQGMVRFGLLVLTVCAACARGLYFHIGETEKRCFIE
                     EIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTF
                     TSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRA
                     RQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK
                     SFFEAKKLV"
     exon            165..265
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            266..391
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            392..538
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            539..1625
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Tmed4"
                     /gene_synonym="1110014L17Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgcaatggca ggtgttgggg tcggaccgct gcaggggatg gtgcgatttg ggctgctggt
       61 gcttactgtg tgtgctgcgt gtgcccgtgg gctctatttc cacatcggcg agactgagaa
      121 gcgctgcttc atcgaggaaa tacccgacga gaccatggtc atcggcaact atcgaactca
      181 gatgtgggac aaacagaaag aggtgttcct gccgtcgacc cccggcctgg gcatgcatgt
      241 agaggtgaag gacccggacg gcaaggttgt actgtcccgg caatacggct ccgagggccg
      301 tttcacgttc acatcccaca cacccggtga ccatcagatt tgtcttcact ccaactccac
      361 cagaatggct ctcttcgctg gaggcaaact gcgtgtacac ttggacatcc aggttggaga
      421 gcatgccaac aactaccccg agatcgctgc taaggataag ttaacagagc tccagcttcg
      481 agctcgccag ttgcttgacc aggtggaaca gatccagaag gagcaggatt atcagaggta
      541 tcgtgaagag cgcttccgtc tgaccagtga gagcaccaac cagagggtcc tgtggtggtc
      601 catcgcccag accgttatcc tcatcctcac tggcatctgg cagatgcgtc acctcaagag
      661 cttctttgag gccaagaagc tggtgtaggg gtctcgccct ataaccttcc ccttttacct
      721 caattatttg ataatttccc cacccagccc ctcatccacc tggaatttga ggaggagaaa
      781 tgaaaaaaca gtgtgtcact ggtgtcacac tggcatcatg gcactggcgt catggcacta
      841 agccactcag accagctacc tgtgaccctg gttctccaag aagcagacgt tggtctaagc
      901 cttcaagagc tgccttaggg tttgggagaa gttggaatta acccaaggtc aagtcctttc
      961 ttttgcctcc gagatgacca aatgcacttg tgtcttctgt ttgttgcttg ttgagtaagc
     1021 agctggcacg cctgtggagg aggaggcctt gcctcaacgt tcctgggtca gtcccgagtt
     1081 ctcccaatgg ctttgtgaat gtaaataagg gcagttcagg gccctgaagg agtgagatgt
     1141 ttttctatat tttagaacta tttttggata aattatatat tttccttcct gattgaatca
     1201 tcatcactcc ctgtaactag cgaaaaccac cagtccagac cttatccatt ctactcattc
     1261 acagttttaa aaactgccat gcagtgattt cggcactctg gggccagaca gcagctccct
     1321 gtcagacggc caacaagagt tctctggaat gcttgtgagt ccgttcccac aggctcacag
     1381 tgtcaggaga gagtggcaga tgctccagtt tcacttaagc agtggtaaac gtttgaaggt
     1441 tcgttttttg ttggaactcc ggatgtagac tagcctagcc tcagatcctc cgtgagtatg
     1501 cctaccaaat gttgtgatta aagaggcagg cgtcaccaca cctgataaat attttcttca
     1561 agggaaccag agtttggttc tttatgcaaa ttttttccca atgaaataaa acatagttaa
     1621 ctgtgaaaaa aaaaaaaaaa aaaaa
//
