LOCUS       NM_025360               1324 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane p24 trafficking protein 3 (Tmed3), mRNA.
ACCESSION   NM_025360
VERSION     NM_025360.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Yang,Y., Liu,S., Xie,C., Li,Q., Gao,T., Liu,M., Xi,M. and Zhao,L.
  TITLE     Trafficking protein TMED3 promotes esophageal squamous cell
            carcinoma
  JOURNAL   Biomed J 46 (2), 100528 (2023)
   PUBMED   35358714
  REMARK    GeneRIF: Trafficking protein TMED3 promotes esophageal squamous
            cell carcinoma.
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 1324)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159164.1, AK004545.1, AK002698.1 and AV243065.1.
            
            On Dec 19, 2009 this sequence version replaced NM_025360.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004545.1, AK002698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY159164.1         1-52
            53-169              AK004545.1         1-117
            170-206             AK002698.1         119-155
            207-1322            AK004545.1         155-1270
            1323-1324           AV243065.1         234-235
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..1324
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /note="transmembrane p24 trafficking protein 3"
                     /db_xref="GeneID:66111"
                     /db_xref="MGI:MGI:1913361"
     exon            1..298
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..784
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /note="integral type I protein; transmembrane emp24
                     domain-containing protein 3; p24gamma4; p24 family protein
                     gamma-4; transmembrane emp24 domain containing 3"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 3
                     precursor"
                     /protein_id="NP_079636.2"
                     /db_xref="CCDS:CCDS23396.1"
                     /db_xref="GeneID:66111"
                     /db_xref="MGI:MGI:1913361"
                     /translation="MVHEAPHASSFQMLLQLLLLLLLRAEPLRSAELTFELPDNAKQC
                     FHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPRGNVIYRETKKQYDSFTYKTEAKGVY
                     RFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVID
                     SQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLKSFFTEKRPVNRA
                     VHS"
     exon            299..547
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1324
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1303..1308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /note="hexamer: AATAAA"
     polyA_site      1323
                     /gene="Tmed3"
                     /gene_synonym="1200002G13Rik; P24b"
                     /note="major polyA site"
ORIGIN      
        1 gccacccgga accgctgtgc tgagctcgcg ccacgtctct tcagggggcc cctcccctct
       61 ccctgctgtc cctgctgtcg ctgcgcggga gcctagagag gactaggccc ggagcatcat
      121 ggtccacgag gctccgcacg cttcatcctt ccagatgctg ctacagctgc tgcttctgct
      181 cctgctccgg gccgagccac tgcggagcgc tgagctcacc ttcgagctgc cggacaacgc
      241 caagcagtgc ttccacgaag aggtggagca gggcgtgaag ttctctctgg attaccaggt
      301 tatcactgga ggccactacg atgtggactg ctatgtggaa gaccccaggg gcaacgtcat
      361 ctacagggag accaagaagc agtatgacag cttcacgtac aagacagagg ccaagggcgt
      421 ctaccggttt tgcttcagta atgagttctc caccttctct cataagaccg tctactttga
      481 cttccaagtg ggtgacgagc cccccattct cccagacatg gggaacaggg tcacggctct
      541 cactcagatg gaatctgcct gtgtaactat tcacgaggct ctgaagactg tgatcgactc
      601 ccagacacac tatcgactgc gggaggctca ggaccgagcc cgagctgaag accttaatag
      661 tcgagtgtcc tactggtctg taggcgagac tattgccctg tttgtggtca gcttcagcca
      721 ggtgctactg ctgaaaagct tctttacaga aaagcgacct gttaacagag cggtccactc
      781 ctagcctcga agtccctccc acagtccctc acccctcccg ggtctcaggt tcctacaggg
      841 ctggtggtgt gacacagaga agagggagag cagcagggag accaaaggcg cacatatctg
      901 atctttgcac tccaacaacg gaagctcaca gagccccggt aatctgattg tattgtgtgt
      961 gtaacattgg ccaaaagtgt ttacaggtca acctagggtt tggtcactac gggaggccag
     1021 tgatctagca tccaatctgt aggagaactc caagtgcctg gacctccagg gcagtttagg
     1081 gttctgccac tactccatga gacattggtc attaggtggt tgtgtcttct tccatcttga
     1141 gaaagggacc ctgagttctt gccttccctt cgtggacctc tctattcctg aggaaagctg
     1201 gtctaatctg gaaacagtag ggtcagacat acaaccagga cccaagtaga gagtgagtga
     1261 gtgcccttgg tgatctatgt ctcctggagg cagaactgtg ctaataaaaa ccaagactga
     1321 gcat
//
