LOCUS       NM_026775               3526 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus transmembrane p24 trafficking protein 10 (Tmed10),
            mRNA.
ACCESSION   NM_026775
VERSION     NM_026775.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Jiao,M., Wang,C., Tang,X., Dai,C., Zhang,N., Fan,A., Qian,Z.,
            Liu,S., Zhang,F., Li,B., Xu,Y., Tan,Z., Gong,F., Lu,Y. and Zheng,F.
  TITLE     Active secretion of IL-33 from astrocytes is dependent on TMED10
            and promotes central nervous system homeostasis
  JOURNAL   Brain Behav Immun 119, 539-553 (2024)
   PUBMED   38663774
  REMARK    GeneRIF: Active secretion of IL-33 from astrocytes is dependent on
            TMED10 and promotes central nervous system homeostasis.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Li,T., Yang,F., Heng,Y., Zhou,S., Wang,G., Wang,J., Wang,J.,
            Chen,X., Yao,Z.P., Wu,Z. and Guo,Y.
  TITLE     TMED10 mediates the trafficking of insulin-like growth factor 2
            along the secretory pathway for myoblast differentiation
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2215285120 (2023)
   PUBMED   37931110
  REMARK    GeneRIF: TMED10 mediates the trafficking of insulin-like growth
            factor 2 along the secretory pathway for myoblast differentiation.
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   Li,Q., Liu,X., Xing,R. and Sui,R.
  TITLE     Transmembrane p24 trafficking protein 10 (TMED10) inhibits
            mitochondrial damage and protects neurons in ischemic stroke via
            the c-Jun N-terminal kinase (JNK) signaling pathway
  JOURNAL   Exp Anim 72 (2), 151-163 (2023)
   PUBMED   36244749
  REMARK    GeneRIF: Transmembrane p24 trafficking protein 10 (TMED10) inhibits
            mitochondrial damage and protects neurons in ischemic stroke via
            the c-Jun N-terminal kinase (JNK) signaling pathway.
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Chen,F., Hasegawa,H., Schmitt-Ulms,G., Kawarai,T., Bohm,C.,
            Katayama,T., Gu,Y., Sanjo,N., Glista,M., Rogaeva,E., Wakutani,Y.,
            Pardossi-Piquard,R., Ruan,X., Tandon,A., Checler,F., Marambaud,P.,
            Hansen,K., Westaway,D., St George-Hyslop,P. and Fraser,P.
  TITLE     TMP21 is a presenilin complex component that modulates
            gamma-secretase but not epsilon-secretase activity
  JOURNAL   Nature 440 (7088), 1208-1212 (2006)
   PUBMED   16641999
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Dudek,J., Volkmer,J., Bies,C., Guth,S., Muller,A., Lerner,M.,
            Feick,P., Schafer,K.H., Morgenstern,E., Hennessy,F., Blatch,G.L.,
            Janoscheck,K., Heim,N., Scholtes,P., Frien,M., Nastainczyk,W. and
            Zimmermann,R.
  TITLE     A novel type of co-chaperone mediates transmembrane recruitment of
            DnaK-like chaperones to ribosomes
  JOURNAL   EMBO J 21 (12), 2958-2967 (2002)
   PUBMED   12065409
  REMARK    Erratum:[EMBO J 2002 Jul 15;21(14):3917]
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   Denzel,A., Otto,F., Girod,A., Pepperkok,R., Watson,R., Rosewell,I.,
            Bergeron,J.J., Solari,R.C. and Owen,M.J.
  TITLE     The p24 family member p23 is required for early embryonic
            development
  JOURNAL   Curr Biol 10 (1), 55-58 (2000)
   PUBMED   10660306
REFERENCE   10 (bases 1 to 3526)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY343029.1, AK084117.1 and AC159244.4.
            
            On Sep 23, 2006 this sequence version replaced NM_026775.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.134322.1,
                                           SRR13862062.4784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY343029.1         1-18
            19-1345             AK084117.1         2-1328
            1346-3526           AC159244.4         47494-49674         c
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.65 cM"
     gene            1..3526
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="transmembrane p24 trafficking protein 10"
                     /db_xref="GeneID:68581"
                     /db_xref="MGI:MGI:1915831"
     exon            1..277
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..712
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="transmembrane trafficking protein; transmembrane
                     emp24 domain-containing protein 10; transmembrane protein
                     Tmp21; 21 kDa transmembrane-trafficking protein;
                     transmembrane emp24-like trafficking protein 10; p24
                     family protein delta-1"
                     /codon_start=1
                     /product="transmembrane emp24 domain-containing protein 10
                     precursor"
                     /protein_id="NP_081051.1"
                     /db_xref="CCDS:CCDS36498.1"
                     /db_xref="GeneID:68581"
                     /db_xref="MGI:MGI:1915831"
                     /translation="MSGLFGPLSRPGPLPSAWLFLLLLGPSSVLGISFHLPVNSRKCL
                     REEIHKDLLVTGAYEITDQSGGAGGLRTHLKITDSAGHILYAKEDATKGKFAFTTEDY
                     DMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSES
                     IVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLI
                     E"
     exon            278..389
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            390..463
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            464..590
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /inference="alignment:Splign:2.1.0"
     exon            591..3526
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1328..1333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="hexamer: ATTAAA"
     polyA_site      1356
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="major polyA site"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="hexamer: AATAAA"
     polyA_site      3526
                     /gene="Tmed10"
                     /gene_synonym="1110014C03Rik; p23; p24delta1; Tmp21"
                     /note="major polyA site"
ORIGIN      
        1 tcccggttcc ggcgcgctag aggccccggg tggtgaacga ggctccggca ccatgtctgg
       61 tttgtttggc ccactctccc ggcctggccc tctcccgtcc gcctggctct ttctgttgct
      121 gctcggcccc agctcggtcc tcggcatctc cttccatctg cccgtgaact ctcgcaagtg
      181 tctccgagag gagatccaca aggacctgct ggtgacgggc gcctacgaga tcaccgacca
      241 gtctgggggc gctggcggcc tgcgcaccca cctcaagatc acagattctg ctggccatat
      301 tctgtatgcc aaagaggatg caaccaaggg gaagtttgcc tttaccacgg aagactatga
      361 catgtttgaa gtgtgttttg agagcaaggg aacagggcgg atacctgacc aactcgtgat
      421 tctagacatg aagcatggag tagaggcgaa aaattatgaa gagattgcaa aagtcgagaa
      481 actcaaacca ctggaggtgg agttacgacg gctcgaggac ctttccgagt ccattgttaa
      541 tgactttgcc tacatgaaga agcgggaaga ggagatgagg gacactaatg agtccacgaa
      601 cacccgggtc ctgtacttca gcatcttttc catgttctgc ctcattggac tagccacctg
      661 gcaggtcttc tacctgcgtc gcttcttcaa ggccaagaag ttgatagagt aatgaggctc
      721 agtgttctgt cccctagagc cagcagaaca tcgctgggac atgcctggcc tagcccaagg
      781 ccattctact aacagtacca tcaaggcaca gctgagcttt cttgccagaa ctgatacttt
      841 tggtatgaga gcacatgggc accacctata cccaacaagt caatgaggac tttaatgcag
      901 taggatttgg actggttttg caacaagatt attaaagtcg cctatggaaa gaaaacaaaa
      961 taaaacaaaa caacaaaccg gggttaccta gataacgcca aagccagcct tcgtcctggg
     1021 tcgcccgcct cacaggatct gtttgagctg tttgcttttt ctctcccacc tgctcatcgc
     1081 cttgtccttc actctagttc tcctcccaag atttctctga ctgcggtcag ctctttcata
     1141 tcagttgtct ctttggtttc cttgtgaaaa caccttgaac ttctcttggt ccttagatga
     1201 aatgtttaca tagcttctgg tgatatcctt cataatttta tgtctcctaa aagggtcatg
     1261 ggtgggacac attaaaaggt gagctttgaa ctgtagataa tctcttaaaa aaatctcatt
     1321 ttagaccatt aaaatgtttg tgctcaactg cttgaagtcc ttgtgtatgt gtgtttagtt
     1381 ctgtccagtt tatcacttgt agatcctgtc gatcatttcc aggtagagta gttccatccc
     1441 atggtcttca tttgcagtgt tgcagctagc cactcccttc tccacccccc cccccacccc
     1501 ccccccgctc tggctcccta atctgctgcc ctgttctgaa ctctaactct gttatgtaaa
     1561 tgggtcatct agagtgtaac ctttggaggt tggctttctc cactcagcat aattcccatg
     1621 aggtgcctct ccaaggcggt gcacatcctg gttttcctcc aggctatgga tggtactgca
     1681 ttgtgcttaa aggtcatgtg ggtggcctgg ggattgggcc taactattaa agttcttagg
     1741 tgaatgtaag ttttcatcac tccgggataa atacctaaga gggccgttgc tgtgctgtgt
     1801 aggaagcaca tggagttcta aaggaagcct ccctgctctg tctagagtgg ctgtatggca
     1861 ggttacagct ctacattctc tgtggtcttt atcattgcta ttttaacttc tccccttgag
     1921 tggatgcctg taatatctca ttatggtttt aatttgcatt ttcctaatgg cagatggcgt
     1981 tgagcatcct ttctcattct tgtcgtttgc catctgtctg tccttgtcag tgagatgtcc
     2041 gttggtggct tttgcccatt tctatgtggg tcatttgttc acttcactgt tgagttctgt
     2101 gtgggttcct ctatcaaatg ggttgttgct tgaacttttc atataacttc taccaggaaa
     2161 aataagtaaa ttttaccagc ccttcatgta tggtcaatca ctgatctaac tcctgttctt
     2221 cagtgttatc tctgagatgt ggatatacgg ggtttaactt ggacatctgg gaaagtcaca
     2281 gatagtaaat acttgaaata tatatgttgt aaaatcaaag ccaaggttca ttcggtggaa
     2341 gttttaggta cctcaaggca gttctggaaa gtgtacccca gtttacagtg cctacctacc
     2401 atacagaagg ctctgggcct gattgccagt ggcgggggcg ggggtggggt gggtacaaat
     2461 gcttgtaaac aggaaaaata cttgtttatc atctaaagtc tttcccactt ctcctgggaa
     2521 agtgggtaac cttttaaccc tgctgacctg ttacagggct tatctcaatt gcagttctga
     2581 gaattacagg gcttgcagta aagaagtgga atattgaagt taccagagaa taccgttagg
     2641 atgacctgga tgaagtatgc aggtggatgg gaaagatgta gtggttaagt ctcaggctgt
     2701 gctgttaagg ttccagttac tatgaactca aaagcctttg tcttatgact tccataaatt
     2761 cctcttgcat ggcatcaagt gttctctggt acaatagtgc catctgctgt tgaaaaatga
     2821 tctaagatct aagatcttag aatacaagtc ctcaccatgg caacagcaga tggtcagaaa
     2881 tctgtaacat tcatatatca agtgatagga gaacaatgta agtatgaaaa gaataaactt
     2941 tggggtcaaa atccatttgt agacttttaa gtgcaaaacc atagcctgtc tgtcccatta
     3001 gcctaacaag agactcctgt tttctgacgt gtgccttccc ccctaaggag cagtgacagc
     3061 cgctctatta gatttctatt ttcttttctg aaaaatgtca atttttcaga gaggagaaaa
     3121 tagagcattc tgtccatgtt tttgtttcca agaacaagta taaacttaag ctctgtagaa
     3181 ctgaaattct ttcaagtcct ttcgatcatt ttgatcatgc ccaaaacaac caaactggac
     3241 aacatgcttt tcagttcagt tgaagagcat ttgcctttga cagtaggcgt gcacaacagc
     3301 atatccgctt tataaacagg tatattatct gcttccctcc gttccagcat agtcaaaata
     3361 actgagaatc atacagtttc aacaaacctt gttccttacc attgtcatga acccccatca
     3421 gagccatctt ctgtttgtta atgggaagag gcatgtggga tttatacagg ctcacctgtt
     3481 ggagatgttt gtgtaaactt tcacaaataa aagctagcag aaacca
//
