LOCUS       NM_028036               1815 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 6 (Tmco6), mRNA.
ACCESSION   NM_028036 XM_987149
VERSION     NM_028036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Song,M., Zhang,C., Cheng,S., Ouyang,D., Ping,Y., Yang,J., Zhang,Y.,
            Tang,Y., Chen,H., Wang,Q.J., Li,Y.Q., He,J., Xiang,T., Zhang,Y. and
            Xia,J.C.
  TITLE     DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+
            T-cell Immunity in Hepatocellular Carcinoma
  JOURNAL   Cancer Res 84 (10), 1613-1629 (2024)
   PUBMED   38381538
  REMARK    GeneRIF: DNA of Neutrophil Extracellular Traps Binds TMCO6 to
            Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027740.11, AK010487.1, AK046207.1 and BF468256.2.
            
            On Aug 12, 2006 this sequence version replaced NM_028036.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010487.1, BC005637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC027740.11        191617-191689
            74-74               AK010487.1         1-1
            75-416              AK046207.1         106-447
            417-669             AK010487.1         344-596
            670-1207            AK046207.1         708-1245
            1208-1788           AK010487.1         1133-1713
            1789-1795           BF468256.2         657-663
            1796-1815           AK010487.1         1720-1739
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..1815
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /note="transmembrane and coiled-coil domains 6"
                     /db_xref="GeneID:71983"
                     /db_xref="MGI:MGI:1919233"
     exon            1..187
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1587
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 6"
                     /protein_id="NP_082312.3"
                     /db_xref="CCDS:CCDS37772.1"
                     /db_xref="GeneID:71983"
                     /db_xref="MGI:MGI:1919233"
                     /translation="MWNRRQGRLRTLAFGVEELRRRRREREAALRKARREQQLVSKRL
                     LREDAPEEVGGQSAAVLLGEAEVQQFLRLAQRGTDEKEREKALVSLRRGLQHPDTQQT
                     FIRLEGSMRTLVGILTSNRALLQLEAARCLHELSHSEQSAVAEACLPATSYLLTYLSG
                     HSSDFIELCLYTLGNLIVESEAVRKQLLPQGIVPAFAACIQSPHVAVLEALGYALSQL
                     LQAKEAPEKIIPSILDSSLPQQMLWLMQPGPKLNLGVAMEFAWCLHYIICSQVNNAVL
                     LTHGALPTLALLLLDLAGTVQRMDDVGLELLACPVLRCLSNLLTEVPAEVMGQQMELR
                     DERLVAALFIFLQFFLQKQPALLPEGLWLLNNLTANSPTFCTSLLSLDLIEPLLQLLP
                     LSNAVCMLVLTVLCNVVEKGPAYCQRLWPGPLLSCVLNTLALSDTEVVGQSLELLQLL
                     FLHQPEAARAFLQQSGLQALEKLQEETQLQERIHALQQIAATHG"
     exon            188..300
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..416
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            417..600
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..705
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            706..791
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..908
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1020
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1207
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1302
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1470
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1815
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /note="putative"
     polyA_site      1815
                     /gene="Tmco6"
                     /gene_synonym="2410015B03Rik"
                     /note="putative"
ORIGIN      
        1 gcagtagact gtttttgttt ttgtttttct ggcctcccgg ttttgtttag cgcctgcgca
       61 gtcccaacct tcctcggggc gcgacgtagc tttggctgca agatgtggaa tcggcggcag
      121 ggccgcctca ggacgctggc gtttggggtg gaggagctgc ggcgccgccg gcgggagcgg
      181 gaggcagccc tgcggaaggc gcggagggag cagcagttag tcagcaagag gctgctgagg
      241 gaagacgccc cggaagaagt cggaggccag agtgcagctg tgctccttgg ggaagccgag
      301 gtccagcagt tccttcggct cgcccaacgg gggacagatg aaaaggagag ggagaaggct
      361 ctggtcagcc ttcgtcgagg cttgcagcac cctgacacac agcaaacctt catcaggctg
      421 gagggcagca tgcggaccct tgttgggatt ttgaccagca accgggcctt gttgcagctt
      481 gaggcggctc ggtgccttca tgagctctct cattctgagc agtctgcagt ggctgaggcc
      541 tgcctgccag cgacttccta cctcctcacc tacctctctg gtcacagctc agatttcata
      601 gagctgtgtc tgtacacact ggggaacctc atcgtggaga gtgaggccgt gagaaagcag
      661 ctcctgccgc agggcattgt cccagccttt gctgcctgca tccagtcccc ccatgtggct
      721 gtgctggaag cacttggata tgccttgtcc cagcttctgc aggctaagga agccccagag
      781 aagatcattc cctctattct ggattccagt cttccccagc agatgctatg gttgatgcaa
      841 ccaggcccga agctgaacct tggggttgcc atggagtttg cttggtgcct tcactatatc
      901 atctgcagcc aggtcaacaa tgctgtactc cttacccatg gggctctgcc cacgttggca
      961 ctgctgcttt tggacttggc tgggactgtg cagagaatgg atgatgtggg actagagctg
     1021 cttgcatgcc ccgtgcttcg gtgtctaagc aacctgttaa cagaagtgcc agcggaggtc
     1081 atgggacagc aaatggagct cagagacgag cgacttgtgg cagccttatt tatctttctc
     1141 cagttcttcc ttcagaaaca gcctgccttg ctacctgagg gcctctggct cctcaacaac
     1201 ctcactgcaa acagtcctac tttttgtacc tccttgctct ctctggatct gatcgagccg
     1261 ctcttgcagt tgttgccact atcaaatgca gtatgcatgt tggtgctcac agttctgtgc
     1321 aatgtcgtag agaagggtcc agcttactgc cagcggttgt ggccaggacc cctgctctcc
     1381 tgcgtgctta acacactggc tctctctgac accgaagtag taggccagag tttggagctg
     1441 ctgcagctgc tattcttgca tcagccagag gctgcccgag ccttcctgca gcagtcaggg
     1501 ctgcaggccc tagaaaagct ccaggaggaa actcagcttc aggagaggat acacgcgctc
     1561 cagcagatag ctgctaccca tggatgacct ggctgctcaa tatcaccctt taccccgcgg
     1621 cgtatttacc ctagggtctc ctacttcact ttagaagctg gtagcttttt gttatacctg
     1681 agtgtggtgt tgcacttgag attgtcttag ttcatgctct tcagcaactt ggctaatgac
     1741 gtacgacatc acagctggca cctggtgggt tttttttttt tttttttttg aggagaaata
     1801 aaggagtatt tttat
//
