LOCUS       NM_026104               1172 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 5 (Tmco5),
            transcript variant 1, mRNA.
ACCESSION   NM_026104
VERSION     NM_026104.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Yamase,K., Tanigawa,Y., Yamamoto,Y., Tanaka,H. and Komiya,T.
  TITLE     Mouse TMCO5 is localized to the manchette microtubules involved in
            vesicle transfer in the elongating spermatids
  JOURNAL   PLoS One 14 (8), e0220917 (2019)
   PUBMED   31393949
  REMARK    GeneRIF: Tmco5 may have a role in vesicle transport along the
            manchette.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845318.8.
            
            On Mar 30, 2020 this sequence version replaced NM_026104.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049568.1, AK007078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL845318.8         76040-76102
            64-107              AL845318.8         76610-76653
            108-257             AL845318.8         77571-77720
            258-381             AL845318.8         78131-78254
            382-432             AL845318.8         79800-79850
            433-504             AL845318.8         80550-80621
            505-561             AL845318.8         83585-83641
            562-621             AL845318.8         84065-84124
            622-686             AL845318.8         84573-84637
            687-744             AL845318.8         85589-85646
            745-785             AL845318.8         87440-87480
            786-1172            AL845318.8         89448-89834
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.03 cM"
     gene            1..1172
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /note="transmembrane and coiled-coil domains 5"
                     /db_xref="GeneID:67356"
                     /db_xref="MGI:MGI:1914606"
     exon            1..63
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            64..107
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..984
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane and coiled-coil domain-containing protein
                     5A"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 5A isoform 1"
                     /protein_id="NP_080380.1"
                     /db_xref="CCDS:CCDS16569.1"
                     /db_xref="GeneID:67356"
                     /db_xref="MGI:MGI:1914606"
                     /translation="MEEQKENQLDYESEKMEILRLAQSKKNIISLNMDLERDMQRIDE
                     ANQELLLEIQEKENEIQRLEHEITQTGNPAEDEEWEKENYTVMEREQALQELEEETAR
                     LERKNETLVHSISELQRKLTRKSQKVIRYEQGDLETTPEESKVKLQQLESSCADQEKE
                     LGKIMEDYVFVSQLCEDQALCIKKYQEALKRIEEELETGYLEREVSKVLSMDSERERS
                     TSLNKMDGFISKGALRFSKSIFRSLLFSTLFFIRLLGYLIFHLSFINPDLLVNALPKI
                     LSRDVLWKLRCFLFPSLTLETEDMLPH"
     exon            108..257
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            258..381
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            382..432
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            433..504
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            505..561
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            562..621
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            622..686
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            687..744
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            745..785
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1172
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /note="hexamer: AGTAAA"
     polyA_site      1172
                     /gene="Tmco5"
                     /gene_synonym="1700095F04Rik; Tmco5a"
                     /note="major polyA site"
ORIGIN      
        1 agagtcttaa gaagaagctc ctgattaggg caggatcaga aagccaaagc acatcggtag
       61 aaggggcctc cgatggaaga acagaaggaa aatcagctgg actatgagtc agaaaaaatg
      121 gaaatcttga gattggccca atcaaagaag aacattatca gcttgaacat ggacctcgaa
      181 agggatatgc agagaataga tgaagccaac caggagctgc ttctcgagat acaagaaaaa
      241 gaaaatgaaa tccagaggct agaacatgag atcacccaga ctgggaaccc tgcagaagac
      301 gaggagtggg agaaggaaaa ctatactgtg atggaaagag aacaagctct gcaggagctg
      361 gaggaagaaa cagccagatt ggagaggaag aatgagactc tggtccacag tatttcagaa
      421 cttcagagaa agcttacaag aaaatcacaa aaggtaatca ggtatgaaca aggtgatcta
      481 gaaacaaccc cagaagagtc caaggttaaa ctacaacagt tggagtcttc ctgtgcagac
      541 caggagaagg agctcggcaa gataatggaa gactatgtgt ttgtgtctca gctctgtgaa
      601 gatcaagctc tctgcataaa gaagtaccag gaagctttga agaggataga agaagaacta
      661 gaaactggat accttgagag agaagtatca aaagtcttaa gcatggattc tgagagagaa
      721 aggagtacga gcctaaataa gatggatggc ttcatcagta aaggggcact gaggttcagt
      781 aaaagtattt ttcgttccct cttgttctcc acgctgtttt tcatcagatt gctgggatac
      841 ctgatcttcc atttaagttt tataaatccc gacctcctgg tcaacgcgct gcctaagata
      901 ctgagcaggg acgtcttgtg gaagctgaga tgtttcctct tcccatctct cacgcttgag
      961 acagaagaca tgttacctca ctgatcccca agccatacct gagggcagcg gaaggcagga
     1021 gggatgaagg cttgcaaatg ggaagtggca aaatctgtgg aggggagaag tgtgtctcag
     1081 ctcttccctc gaggttggcc tacttagtga ccatctgtct cagtgtcacg tttccaggat
     1141 taaccttgcc cagtaaagaa ctctgtcaat aa
//
