LOCUS       NM_029857               3322 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 4 (Tmco4),
            transcript variant 2, mRNA.
ACCESSION   NM_029857
VERSION     NM_029857.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029092.1 and BB157255.1.
            
            On May 9, 2009 this sequence version replaced NM_029857.2.
            
            Transcript Variant: This variant (2) uses two alternate exons in
            the 5' UTR compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029092.1, AK171189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3269              AK029092.1         1-3269
            3270-3322           BB157255.1         243-295
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..3322
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /note="transmembrane and coiled-coil domains 4"
                     /db_xref="GeneID:77056"
                     /db_xref="MGI:MGI:1924306"
     exon            1..383
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..498
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..643
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            644..762
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..941
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             772..2667
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /note="novel DUF726 domain containing protein"
                     /codon_start=1
                     /product="transmembrane and coiled-coil domain-containing
                     protein 4"
                     /protein_id="NP_084133.1"
                     /db_xref="CCDS:CCDS18837.1"
                     /db_xref="GeneID:77056"
                     /db_xref="MGI:MGI:1924306"
                     /translation="MATWNRPHPRQPVAPEPAAEDDSQQPLGRELSEANRFAYAALCG
                     FSLSQLFPEPEQSSFCTEFVTGLVKWLHLSESVLPTIMAFASGLGGEGADIFAQTLLQ
                     DPILRDNPSAVSQDLLSFSLKNGHYDARARVLVCHVTSLLQVPMEELDILEEVFLESL
                     KDAKEEESETAEASRKRKEKRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAAT
                     IIGSAGAAALGSVAGIAVMTSLFGAAGAGLTGYKMKKRVGAIEEFMFLPLTEGRQLHI
                     TIAITGWLGSGRYRTFNAPWMALARSQEQYCLAWEAKYLMELGNALETILSGLANMVA
                     QEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGR
                     RPVTLIGFSLGARVIYFCLQEMAQEQDCQGIIEDVVLLGAPVEGDPKHWEPFRNVVSG
                     RIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRRMENVDLTSVVNGHLDYAKQM
                     DAILKVVGIRTKPGWREKGLPLAPGSLPQEEPLQTAIVSTDEIILQDGQSQGPASEDS
                     LKTTIPSSASQAQMPAGLNQSTEDSLSTAAAPAEGHLICSHGVGPNPLGCPDCTHGTQ
                     ESCTELD"
     exon            942..1116
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1144
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1277
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1375
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1519
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1639
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1804
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1941
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2026
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2144
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2262
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..3322
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3318
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggctcttttc aagtgtggcg gcaaaatttg gaagcttccc cttcaagtgt ctgctcgaac
       61 tcccctcatg ccagcccagc ccctggtgag cactctctgc agacccctcc tgtgccccgc
      121 gctctcgctt cctggggagc gggagacaca gaagtgcggg tcccgtccca aggccagcac
      181 ccgggcgatg gctttggtgg cttaggtggc ggtgcgcccg gcccagcccg gaaggcccgg
      241 gccctagggc tgcgcaggcg ggaccggccc gggccggtgt ggggcggctg ggccagggag
      301 agaacaggcg gggagcgcca gggcgggagc tgcggggctg ccagaagttc tgccgtcgtc
      361 ccatccgtcg ctgccgcctc cagtgccggg agcccgtgca tgtgctagac aaaccaccct
      421 gtcactgagc ttggaatctg aagtcacact ggcctagggt aggactacag catgccagtg
      481 atgtgacctt cacttttggt tccacaccct ctggacccat ggctggtttt tctggtttag
      541 tctgtagagc aatttgcata tttccttgaa gaactctctg aagctttaca gcctgtcctt
      601 ggactcacag agagggacgc ccacgttggt tctccagaat tggaatgaaa gccccttcat
      661 tcttcagtgt ttgatgcatg ccgtagtcta agccagtgga agctcggggc gtaagcaagg
      721 actccacctg ccctgagact tacattcctt gtgtgcacac aggggctggg aatggccaca
      781 tggaacaggc cacacccaag gcagcctgtg gcaccagagc cagctgcaga agacgattcc
      841 cagcagcccc tgggccggga gctctcggag gccaatcgct tcgcctatgc cgccctgtgt
      901 ggcttctcgt tgtcacagct gtttccagaa cctgaacaaa gctccttctg cacagaattt
      961 gtgacgggcc tggtgaaatg gctgcatctg tctgaaagtg tcctcccaac cataatggcc
     1021 tttgccagtg gcctgggagg cgaaggagcc gacatctttg ctcagacttt attgcaggac
     1081 cccattctga gagacaaccc atcagcagtc agtcaggacc tcctgagctt ctcactcaag
     1141 aatggacact atgatgcccg ggccagagtc ctcgtttgtc atgtgacctc cctgctccag
     1201 gtgcccatgg aggagcttga cattctggaa gaggtgttcc tggagagcct gaaggacgcc
     1261 aaagaggagg agtctgagac cgcagaggca tcccggaaga ggaaagaaaa acggaggaag
     1321 tggaaacgct atcttctgat aggcctggcc acagttggag gcgggacagt gattggtgtg
     1381 actggggggc tagctgcccc acttgtcgct gcaggagccg caaccatcat aggcagtgcc
     1441 ggggcagccg cgttgggctc agtggctggc atcgctgtta tgacttcact gtttggtgca
     1501 gccggagctg gcctgacagg atacaagatg aagaagcgag tcggggccat tgaggagttc
     1561 atgttcctgc ctttgacgga aggccggcag ctacatatca ccattgccat cactggctgg
     1621 ctcgggtccg gcagataccg cacatttaat gccccatgga tggccctagc ccgcagccag
     1681 gagcagtact gcctggcctg ggaggccaag tacctgatgg agttgggcaa tgccctggag
     1741 accatcctca gtggcctcgc taacatggta gcacaggagg ctctcaagta cacagtgctc
     1801 tctggtatcg tggctgctct aacctggcca gcctcactcc tcagcgtcgc caatgtcatc
     1861 gacaacccct ggggcgtgtg cctccaccga tcggcagaag ttggcaagca cctggcgcac
     1921 atccttctct cacggcaaca gggccggaga cctgtcacct tgattggatt cagcctggga
     1981 gccagagtca tctacttttg tctgcaagaa atggctcagg agcaagattg ccaagggatc
     2041 atcgaggatg tggtccttct gggcgcacca gtagaagggg accccaagca ctgggaacca
     2101 ttccggaatg tggtgtctgg gagaatcatc aatggctact gcaggggaga ctggctgctg
     2161 agcttcgtgt accgcacatc ttccgtgcag ctccgcgtcg ccggcctcca gcctgtgctg
     2221 ctgcaggacc ggaggatgga gaatgtggac ctgacctccg tggtcaatgg ccacttggac
     2281 tacgccaagc aaatggatgc catcctgaag gttgtgggca tccgcaccaa gcctggctgg
     2341 agagagaagg gactcccact ggcccctggc agcttgcccc aagaagagcc tctccagaca
     2401 gccatagtct ctacagatga gataatcctc caggatggac aaagccaggg acctgcctca
     2461 gaagacagtc tcaaaaccac cataccttcc agtgccagcc aagcccagat gccagcaggg
     2521 ctgaaccagt ccacagagga ctcgctctct actgctgctg ctccggcaga gggacacctg
     2581 atctgcagcc atggtgtggg tcccaaccca ctgggctgcc ctgactgcac ccatgggacc
     2641 caggagtcct gtacagaact ggactgaccc agcaggcatc tggactacct ctccagactt
     2701 ctgtatgcaa ctttctctaa cccttgctga cttcccagag agctctaggg gtggggaatt
     2761 tccacaagtg ccttttttaa acagatagga gctagaatgg agaggtgagg gagaaagcac
     2821 tggctttagg aggcaggact agcagtatga cctgccaggt caacccagcg ctaaaccagt
     2881 gtaggctcct gccctgcagg tcccatccaa aggcccaaac gtttctgtgg gactagaggt
     2941 ccccgtgctc ccttttctcc aacctcagtg gacccaagtg tcttccagat cttccatcaa
     3001 ctctcccagg ctgcccactg atcccaggct ccaccagcga gcgttttcag gtgccaatga
     3061 gacactttgc tcccctgccc ttggaaggag cagctctgtc cagtacattt atgcaggctg
     3121 ggtgcactgg acaacggcag gcgtaacagg catcgatgtg atgtatgtgg cagcccaccc
     3181 tgagcttgtg aaacatgtga ccctggatag aattgtagca agaggaataa aggcagaagt
     3241 cacagtcagg ctctcaagga ctgggccttg gtaagcatgg attacatgag gggggaccaa
     3301 taaacactga ttatcacacc ct
//
