LOCUS       NP_084133                631 aa            linear   ROD 04-JUN-2024
DEFINITION  transmembrane and coiled-coil domain-containing protein 4 [Mus
            musculus].
ACCESSION   NP_084133
VERSION     NP_084133.1
DBSOURCE    REFSEQ: accession NM_029857.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 631)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029092.1 and BB157255.1.
            
            Transcript Variant: This variant (2) uses two alternate exons in
            the 5' UTR compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029092.1, AK171189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     Protein         1..631
                     /product="transmembrane and coiled-coil domain-containing
                     protein 4"
                     /note="novel DUF726 domain containing protein"
                     /calculated_mol_wt=67814
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WU4.2)"
     Site            200..220
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WU4.2)"
     Region          218..518
                     /region_name="DUF726"
                     /note="Protein of unknown function (DUF726); pfam05277"
                     /db_xref="CDD:368366"
     Site            228..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WU4.2)"
     Site            343..363
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WU4.2)"
     Region          555..595
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WU4.2)"
     CDS             1..631
                     /gene="Tmco4"
                     /gene_synonym="4632413C14Rik"
                     /coded_by="NM_029857.3:772..2667"
                     /db_xref="CCDS:CCDS18837.1"
                     /db_xref="GeneID:77056"
                     /db_xref="MGI:MGI:1924306"
ORIGIN      
        1 matwnrphpr qpvapepaae ddsqqplgre lseanrfaya alcgfslsql fpepeqssfc
       61 tefvtglvkw lhlsesvlpt imafasglgg egadifaqtl lqdpilrdnp savsqdllsf
      121 slknghydar arvlvchvts llqvpmeeld ileevflesl kdakeeeset aeasrkrkek
      181 rrkwkrylli glatvgggtv igvtgglaap lvaagaatii gsagaaalgs vagiavmtsl
      241 fgaagagltg ykmkkrvgai eefmflplte grqlhitiai tgwlgsgryr tfnapwmala
      301 rsqeqyclaw eakylmelgn aletilsgla nmvaqealky tvlsgivaal twpasllsva
      361 nvidnpwgvc lhrsaevgkh lahillsrqq grrpvtligf slgarviyfc lqemaqeqdc
      421 qgiiedvvll gapvegdpkh wepfrnvvsg riingycrgd wllsfvyrts svqlrvaglq
      481 pvllqdrrme nvdltsvvng hldyakqmda ilkvvgirtk pgwrekglpl apgslpqeep
      541 lqtaivstde iilqdgqsqg pasedslktt ipssasqaqm paglnqsted slstaaapae
      601 ghlicshgvg pnplgcpdct hgtqesctel d
//
