LOCUS       NM_172282               4533 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transmembrane and coiled-coil domains 3 (Tmco3),
            transcript variant 1, mRNA.
ACCESSION   NM_172282
VERSION     NM_172282.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Holling,T., Brylka,L., Scholz,T., Bierhals,T., Herget,T.,
            Meinecke,P., Schinke,T., Oheim,R. and Kutsche,K.
  TITLE     TMCO3, a Putative K+ :Proton Antiporter at the Golgi Apparatus, Is
            Important for Longitudinal Growth in Mice and Humans
  JOURNAL   J Bone Miner Res 38 (9), 1334-1349 (2023)
   PUBMED   37554015
  REMARK    GeneRIF: TMCO3, a Putative K[+] :Proton Antiporter at the Golgi
            Apparatus, Is Important for Longitudinal Growth in Mice and Humans.
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4533)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY146007.1, AK148252.1 and AK033499.1.
            
            On Jan 28, 2006 this sequence version replaced NM_172282.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148252.1, AK088866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               BY146007.1         99-296
            199-281             AK148252.1         2-84
            282-2912            AK033499.1         43-2673
            2913-4533           AK148252.1         2716-4336
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..4533
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /note="transmembrane and coiled-coil domains 3"
                     /db_xref="GeneID:234076"
                     /db_xref="MGI:MGI:2444946"
     exon            1..375
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..890
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1070
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1262
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1391
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1484
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1671
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1792
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1988
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2139
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2219
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2369
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..4533
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /note="major polyA site"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3079
                     /gene="Tmco3"
                     /gene_synonym="B230339H12Rik"
ORIGIN      
        1 agcgtttggg tcacatcgta acctctctcg gaggctgttg ctgttctgag gctcttaggc
       61 ttacgcactc tctggaagct ggctggccgg ccggctcccg ggactccagt tcccggcgtg
      121 catcgcgccg cgcgaaggac gacggagctg tccatcggca gcctgcttaa aggagccgca
      181 cctactttcc agctgcgcgt cagaagcgcc tgaagtaaga agagggcggt gccgtcctcg
      241 gtgtcctggt cccgaggcca ggaaagagat gagggcaatt ctttggcggc cctgaggttc
      301 gctgcgtcgg ggaactctcg atcggggaca gtgatgctga ggtcgcatgt ccagagagcg
      361 gcctcctcca tcgggctgaa aatgtgtgtg taaaatgcca gccaactata gcagcagtct
      421 ctgctcccac cccacatcct tggaccatga aggtactgga ccagagtctc ctctggatgc
      481 tgcttccctt ctttcacctg atagccagtg ctgccgagca cgaggaggtg gccaagcatg
      541 ccatcaagct gcaccgcggg aagggcgcca ctgccactca gaggaaacag tgggccctgg
      601 acagctgcag gaggctcacc gggctcctga ggcagaagaa tgtggtcctc aacaaactga
      661 agaatgccat cagagccgtg gagaaggaca ccagcctttc gggcgaggag aagctcttcc
      721 aggtgcacac attcgagatt ttccagaaag agctgaatga aagtgaaaat tcgatcttcc
      781 aggccatcta cggactgcaa agagccctgc agggcgacta cagagacgtg gtcaacatga
      841 aagagagcag caagcagcgg ctggaggctc tgagggaggc tgccattaag gaggagacag
      901 agtatgtgga acttcttgcc gcagaaaaac accaagtgga agccctgaaa aacatgcaac
      961 atcaaaacaa gagtctctcc atgcttgacg agatcctcga agatgtgagg aaagccgccg
     1021 accgtctgga ggaggagatc gaggagcacg ccttcgacga caataaatca gtcaaaggcg
     1081 tcaactttga ggcagttctg agagtggagg aggaggaggc cagctccaag cagaatatga
     1141 cgaagcggga ggtggaggac ggcctgggtc tcagcatgct catcgactcc cagaacaacc
     1201 agtacattct gaccaagccc agagattcta ctatcccacg cgcagaccac cacttcataa
     1261 aggacatcgt gaccataggg atgctgtcct taccatgtgg ctggctgtgt acagcaatag
     1321 gtctgcctac gatgtttggg tatataattt gtggcgtgct tctggggcct tcaggactga
     1381 acagtattaa gtctattgta caggtggaaa cattaggaga atttggggtc ttctttactc
     1441 tgtttctggt tggcttagaa ttttctccag agaagctaag aaaggtgtgg aggatatcct
     1501 tacaaggacc ctgctatatg acgctgctga tgattgcctt tggcttatgg tggggacacc
     1561 tcctgcggat cagacccact cagagtgtct tcatttccac ctgtctgtcc ttgtcgagca
     1621 cacccctggt atccaggttc ctagtgggaa gtgcccgagg tgataaagaa gcaggtgaca
     1681 tcgactacag cacagtgctg cttggcatgc tggtgatgca agacgtgcag ctggggctgt
     1741 tcattgccgt catgccaact ctcatacagg ccggagcggg cgcctcttcc agcgttgtca
     1801 tggaagtatt gcgcatactg tttctgattg gacaaattct cttttcgcta gctgctgtct
     1861 ttcttttgtg tcttgtcatg aagacgtatc tcataggacc gtattatcga aagctgcacc
     1921 tggagagcaa ggggaacaaa gagatcctcg tcctgggagt gtcagccttc accttcctga
     1981 tgctgacggt cacagagctg ctggacgtct ccatggagct tggatgcttc ctggctggag
     2041 cgctggtctc ttcccaaggg cacatggtca ccgaggagat catgacttac atcgagccta
     2101 tccgtgactt cctggccatc atcttcttcg catccatagg gctccatgtg ttccccacct
     2161 ttgtgatcta tgagttgacg gtgctggtgt tcctcaccct gtccgtggtc atcatgaagt
     2221 ttgtgttggc agtgctggtc ttgtctctca tcctgccgag gagcagccag tacatcaagt
     2281 ggatcgtatc cgctgggctg gcacaggtca gcgagttctc ctttgtcctg gggagtcgag
     2341 cacggagagc aggcatcctc tccagagagg tgtacctcct tatcctaagt gtgaccacac
     2401 tcagcctctt actcgcccca gtgctgtgga aagcagccat taccaagtgt gtgccgagac
     2461 cagagaggcg ctcaagtctc tgacaacacc cgaggacgac aggctgtggg gcaaggatcc
     2521 ttcgggggtt ccagtcccga gacggtctgc tgctgcgcct ctctgctggc ttcccagcag
     2581 agacagagta acacgggcca agaggcagcg ccctcatgct tgcttgctat ttcaaagact
     2641 ctcctgtcat gtttaagaat tttccagagt aatttatttg cagtcagttg attatgtaca
     2701 gagttttaac actgcatttt acaatcacct gaactatttt gcctggatgt gcctttttta
     2761 atgaaaatta ttaacttcca tttgttaatt taccagctta tgattttttg gtaaagaaga
     2821 aaaattagaa agccattata tttattgtac aattatagta gttggtcaaa tatttgttat
     2881 taaacataat agcaatatgc gattttaatt ttatttctga gcttggaaac ttacttttga
     2941 tctttaaaac ctcagtgtcc ccttgcctct tgtcactgtt ttaaataaaa cattttcatg
     3001 ttcattttta ttagttttaa tttgattttg aatcacaaga atatgcattc ttaagtaaag
     3061 accatttatg atcagggtat aattatttga aatttactga gaatctcatt tttttttaaa
     3121 aaagatttac ttatttttct gtggttcttt gcctacatgt atgtgtgtat atgagggtgc
     3181 cagatcccca gggactggag ttacagttag cagccatgtg ggtgctagga gctgaaccta
     3241 ggggctatgg aagagcagcc agtctcctaa cccatgagcc atctttccag cctccaaaaa
     3301 tctcatttta tcttagattt ttgtgttgaa ctaatcattg gcaaaatctt gccaatgttt
     3361 tttaatttta gatttactta catgtctgta tgagcatcac ctgtgctcct ggtgtctgaa
     3421 gaagtgagaa gggggctgga tgcactggac ctagagtaat gggtgactgt gagatgctgt
     3481 gtgagtgctg ggaaccaaac ctgggtcctt tcccagagca atgagtgccc ttaactgccc
     3541 tcaactgtct ctccagcccc agctagtggt tttttttttt aataaggacc actcatatgt
     3601 catcatatag ttcttttttt aaaaaaagat ttatttattg ttatatgtaa gtacactgta
     3661 gctgtcttaa gacacaccag aagagggtgt cagatctcat tatgagtggt tgtgagccac
     3721 catgtggttg ctgggatttg aactcaggac cttcagaaga gcagtcaatg ctcttaacca
     3781 ctgagccatc tctccagccc catcatatag ttattaaaga ccaaatgaat gcattttaaa
     3841 gatgttttaa ttatcaggta tcctagaaat gaagacctga cccttgacag ggctctcctg
     3901 aggggcgtgg tcagtctctc catggtgctg tagctggata atctgttggg aactggaatt
     3961 tactcttagt tttagatgct gagaagcaca aggtcaaaag ggggaaggct ctgtccttct
     4021 gctctggggc tgcatgctgc atagaggatt tcaagtagtg aggagggcag acagcccagt
     4081 tccaggggct tgtttataat taatgtaatt aacccaccca tgagggcaag ttctctctga
     4141 ttgaatctct tctgagccca cccttccaac actgttgtat tggggattaa acttgtagca
     4201 cctgaactct ggggtctgga aacattcacg gaataggtgt tttatttttc agttgcatac
     4261 actttctatt ttagttgaca gttacaatta tatatgtgta tactgtgaac aacatcactg
     4321 ttactctaaa caatttctct gtatatactg gttttcagag ctggacaaat tgaccataaa
     4381 tgctgaggta gagggacaga gtataaggtg tgattatgta ttttatgtgt gcatatatag
     4441 attgcagtaa tgtaaattaa gccactgaag tcaattgaaa tactgtgtct tcttgaagtg
     4501 gtgaacaata gaagcattgt cttttagaaa atg
//
